BGC0001127: jagaricin biosynthetic gene cluster from Janthinobacterium agaricidamnosum
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Location: 1 - 45,262 nt. (total: 45,262 nt).
This entry is originally from NCBI GenBank HE967328.2.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001127
Short description jagaricin biosynthetic gene cluster from Janthinobacterium agaricidamnosum
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
HE967328.2
via
Compounds
  • jagaricin
Species Janthinobacterium agaricidamnosum [taxonomy]
References
Chemical products information
jagaricin Evidence:
Copy SMILES
C56H84N12O16
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CCM43853.1
 1 - 933 (+) bacterial regulatory, Fis family protein
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    • CCM43854.1
    • mug
    		 1015 - 1596 (-) G/U mismatch-specific DNA glycosylase
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      • CCM43855.1
      		 1748 - 2791 (-) SPFH domain / Band 7 family protein
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        • CCJ67643.1
        		 2778 - 4397 (-) cyclic peptide transporter; siderophore ABC transporter
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          • CCM43856.1
          		 4437 - 4616 (-) putative membrane protein
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            • CCM43857.1
            		 5355 - 5876 (+) GTPase domain-containing protein
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              • CCJ67644.1
              • mbtH
              		 5965 - 6198 (+) MbtH
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                • CCJ67645.1
                • jagA
                		 6246 - 11117 (+) JagA
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                  • CCJ67646.1
                  • jagB
                  		 11181 - 19943 (+) JagB
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                    • CCJ67647.1
                    • jagC
                    		 20030 - 30973 (+) JagC
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                      • CCJ67648.1
                      • jagD
                      		 30990 - 39770 (+) JagD
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                        • CCJ67649.1
                        • dctA
                        		 40562 - 41854 (-) C4-dicarboxylate transporter DctA
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                          • CCM43858.1
                          		 41922 - 43214 (-) amidase family protein
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                            • CCM43859.1
                            		 43525 - 44250 (+) bacterial regulator helix-turn-hlix, LysR family protein
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                              • CCM43860.1
                              		 44222 - 45262 (-) bifunvtional NMN adenylyltransferase/Nudix hydrolase
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                                Biosynthesis information

                                Biosynthetic modules

                                Name
                                Unk01
                                Type
                                nrps-type1
                                Genes
                                jagA
                                Substrates
                                threonine (evidence: Structure-based inference, Homology)
                                Integrated Monomers
                                Domains
                                adenylation
                                Name
                                Unk02
                                Type
                                nrps-type1
                                Genes
                                jagB
                                Substrates
                                threonine (evidence: Structure-based inference [1])
                                Integrated Monomers
                                Domains
                                adenylation
                                Name
                                Unk03
                                Type
                                nrps-type1
                                Genes
                                jagB
                                Substrates
                                tyrosine (evidence: Structure-based inference [1])
                                Integrated Monomers
                                Domains
                                adenylation
                                Name
                                Unk04
                                Type
                                nrps-type1
                                Genes
                                jagC
                                Substrates
                                threonine (evidence: Structure-based inference, Homology)
                                Integrated Monomers
                                Domains
                                adenylation
                                Name
                                Unk05
                                Type
                                nrps-type1
                                Genes
                                jagC
                                Substrates
                                glutamine (evidence: Structure-based inference [1])
                                Integrated Monomers
                                Domains
                                adenylation
                                Name
                                Unk06
                                Type
                                nrps-type1
                                Genes
                                jagC
                                Substrates
                                glycine (evidence: Structure-based inference [1])
                                Integrated Monomers
                                Domains
                                adenylation
                                Name
                                Unk07
                                Type
                                nrps-type1
                                Genes
                                jagD
                                Substrates
                                allo-threonine (evidence: Structure-based inference [1])
                                Integrated Monomers
                                Domains
                                adenylation
                                Name
                                Unk08
                                Type
                                nrps-type1
                                Genes
                                jagD
                                Substrates
                                histidine (evidence: Structure-based inference [1])
                                Integrated Monomers
                                Domains
                                adenylation
                                Annotation changelog

                                Entry version: 4

                                Date
                                Changes
                                Submitters
                                Reviewers
                                2022-10-07
                                Update chemical activity to schema version 2.11
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                Entry version: 3

                                Date
                                Changes
                                Submitters
                                Reviewers
                                2022-09-15
                                Update compound structure (SMILES) for jagaricin
                                • (ID: 5UL74VURKJ25VSPPPO3H2NYB)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                2022-09-15
                                Updated bioactivity data
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                2022-09-15
                                Added NRP substrate specificities
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                Entry version: 2

                                Date
                                Changes
                                Submitters
                                Reviewers
                                2019-10-16
                                Migrated from v1.4
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                2019-10-16
                                Updated compound(s) information (NPAtlas curation)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                Entry version: 1

                                Date
                                Changes
                                Submitters
                                Reviewers
                                2015-06-12
                                Submitted
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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