BGC0001130: fabclavine Ia biosynthetic gene cluster from Xenorhabdus budapestensis
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 52,424 - 100,650 nt. (total: 48,227 nt).
This entry is originally from NCBI GenBank NIBS01000014.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Polyketide
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001130
Short description fabclavine Ia biosynthetic gene cluster from Xenorhabdus budapestensis
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide (Other)
Loci NCBI GenBank: NIBS01000014.1
Compounds
  • fabclavine Ia
  • fabclavine Ib
  • fabclavine IIa
  • fabclavine IIb
Species Xenorhabdus budapestensis [taxonomy]
References
Chemical products information
fabclavine Ia
Copy SMILES
C70H125N13O13
fabclavine Ib
Copy SMILES
C68H121N13O12
fabclavine IIa
Copy SMILES
C67H123N15O13
fabclavine IIb
Copy SMILES
C65H119N15O12
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • Xbud_02632
  • PHM26604.1
 52424 - 52945 (+) NUDIX hydrolase
copy AA seq
copy Nt seq
  • Xbud_02633
  • PHM26605.1
 53418 - 54425 (+) hypothetical protein
copy AA seq
copy Nt seq
  • Xbud_02634
  • PHM26606.1
 54620 - 60691 (+) malonyl CoA-acyl carrier protein transacylase
copy AA seq
copy Nt seq
  • Xbud_02635
  • PHM26607.1
 60895 - 65370 (+) phenolpthiocerol synthesis type-I polyketide synthase ppsB
copy AA seq
copy Nt seq
  • Xbud_02636
  • PHM26608.1
 65367 - 68402 (+) glutamate-1-semialdehyde-2,1-aminomutase
copy AA seq
copy Nt seq
  • Xbud_02637
  • PHM26609.1
 68399 - 69166 (+) 3-ketoacyl-ACP-reductase CylG
copy AA seq
copy Nt seq
  • Xbud_02638
  • PHM26610.1
 69279 - 70511 (+) linear gramicidin synthetase subunit B
copy AA seq
copy Nt seq
  • Xbud_02639
  • PHM26611.1
 70575 - 71372 (+) amidohydrolase
copy AA seq
copy Nt seq
  • Xbud_02640
  • PHM26612.1
 71529 - 84629 (+) pvdj
copy AA seq
copy Nt seq
  • Xbud_02641
  • PHM26613.1
 84693 - 91511 (+) pyoverdine synthetase D
copy AA seq
copy Nt seq
  • Xbud_02642
  • PHM26614.1
 91541 - 96550 (+) Phthiocerol synthesis polyketide synthase type I PpsE
copy AA seq
copy Nt seq
  • Xbud_02643
  • PHM26615.1
 96547 - 98133 (+) Amino acid adenylation
copy AA seq
copy Nt seq
  • Xbud_02644
  • PHM26616.1
 98144 - 99091 (+) daunorubicin-DIM-transport ATP-binding protein ABC transporter DrrA
copy AA seq
copy Nt seq
  • Xbud_02645
  • PHM26617.1
 99084 - 100181 (+) ABC transporter
copy AA seq
copy Nt seq
Polyketide-specific information
Subclass Other
Starter unit Acetoacetyl-CoA
Cyclic? no
Release type
  • Claisen condensation
NRP-specific information
Subclass N/A
Cyclic? yes
NRP-synthases
Gene Modules
Xbud_02640
Module ?
Specificity: aspartic acid branched
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: histidine / phenylalanine
Evidence for specificity:
  • Feeding study
Module ?
Specificity: asparagine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: asparagine
Evidence for specificity:
  • Feeding study
Xbud_02641
Module ?
Specificity: threonine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: proline
Evidence for specificity:
  • Feeding study
Annotation changelog
MIBiG version Submitter Notes
1.1
  • Hidden contributor (ID: SCFYH7235HZBUM2XBV52IUHT, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: H5KVDLSVQ3TJW7SKCDNBDEVC, no GDPR consent given).
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update compound structure (SMILES) for fabclavine Ia
  • Add new compound: fabclavine Ib
  • Add new compound: fabclavine IIa
  • Add new compound: fabclavine IIb
  • Updated bioactivity data
  • Added NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.