BGC0001130: fabclavine Ia biosynthetic gene cluster from Xenorhabdus budapestensis
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Location: 52,424 - 100,650 nt. (total: 48,227 nt).
This entry is originally from NCBI GenBank NIBS01000014.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001130
Short description fabclavine Ia biosynthetic gene cluster from Xenorhabdus budapestensis
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Unknown)
Loci
NIBS01000014.1
52424 - 100650
via Gene expression correlated with compound production
Compounds
  • fabclavine Ia
  • fabclavine Ib
  • fabclavine IIa
  • fabclavine IIb
Species Xenorhabdus budapestensis [taxonomy]
References
Chemical products information
fabclavine Ia Evidence:
Copy SMILES
C70H125N13O13
fabclavine Ib Evidence:
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C68H121N13O12
fabclavine IIa Evidence:
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C67H123N15O13
fabclavine IIb Evidence:
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C65H119N15O12
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • Xbud_02632
  • PHM26604.1
 52424 - 52945 (+) NUDIX hydrolase
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    • Xbud_02633
    • PHM26605.1
    		 53418 - 54425 (+) hypothetical protein
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      • Xbud_02634
      • PHM26606.1
      		 54620 - 60691 (+) malonyl CoA-acyl carrier protein transacylase
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        • Xbud_02635
        • PHM26607.1
        		 60895 - 65370 (+) phenolpthiocerol synthesis type-I polyketide synthase ppsB
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          • Xbud_02636
          • PHM26608.1
          		 65367 - 68402 (+) glutamate-1-semialdehyde-2,1-aminomutase
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            • Xbud_02637
            • PHM26609.1
            		 68399 - 69166 (+) 3-ketoacyl-ACP-reductase CylG
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              • Xbud_02638
              • PHM26610.1
              		 69279 - 70511 (+) linear gramicidin synthetase subunit B
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                • Xbud_02639
                • PHM26611.1
                		 70575 - 71372 (+) amidohydrolase
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                  • Xbud_02640
                  • PHM26612.1
                  		 71529 - 84629 (+) pvdj
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                    • Xbud_02641
                    • PHM26613.1
                    		 84693 - 91511 (+) pyoverdine synthetase D
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                      • Xbud_02642
                      • PHM26614.1
                      		 91541 - 96550 (+) Phthiocerol synthesis polyketide synthase type I PpsE
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                        • Xbud_02643
                        • PHM26615.1
                        		 96547 - 98133 (+) Amino acid adenylation
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                          • Xbud_02644
                          • PHM26616.1
                          		 98144 - 99091 (+) daunorubicin-DIM-transport ATP-binding protein ABC transporter DrrA
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                            • Xbud_02645
                            • PHM26617.1
                            		 99084 - 100181 (+) ABC transporter
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                              Biosynthesis information

                              Biosynthetic modules

                              Name
                              Unk01
                              Type
                              nrps-type1
                              Genes
                              Xbud_02640
                              Substrates
                              aspartic acid branched (evidence: Structure-based inference, Sequence-based prediction)
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              Unk02
                              Type
                              nrps-type1
                              Genes
                              Xbud_02640
                              Substrates
                              histidine, phenylalanine (evidence: Feeding study [1])
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              Unk03
                              Type
                              nrps-type1
                              Genes
                              Xbud_02640
                              Substrates
                              asparagine (evidence: Structure-based inference, Sequence-based prediction)
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              Unk04
                              Type
                              nrps-type1
                              Genes
                              Xbud_02640
                              Substrates
                              asparagine (evidence: Feeding study [1])
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              Unk05
                              Type
                              nrps-type1
                              Genes
                              Xbud_02641
                              Substrates
                              threonine (evidence: Structure-based inference, Sequence-based prediction)
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              Unk06
                              Type
                              nrps-type1
                              Genes
                              Xbud_02641
                              Substrates
                              proline (evidence: Feeding study [1])
                              Integrated Monomers
                              Domains
                              adenylation
                              Annotation changelog

                              Entry version: 4

                              Date
                              Changes
                              Submitters
                              Reviewers
                              2022-10-07
                              Update chemical activity to schema version 2.11
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                              Entry version: 3

                              Date
                              Changes
                              Submitters
                              Reviewers
                              2022-09-15
                              Update compound structure (SMILES) for fabclavine Ia
                              • (ID: H5KVDLSVQ3TJW7SKCDNBDEVC)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              2022-09-15
                              Add new compound: fabclavine Ib
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              2022-09-15
                              Add new compound: fabclavine IIa
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              2022-09-15
                              Add new compound: fabclavine IIb
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              2022-09-15
                              Updated bioactivity data
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              2022-09-15
                              Added NRP substrate specificities
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                              Entry version: 2

                              Date
                              Changes
                              Submitters
                              Reviewers
                              2019-10-16
                              Migrated from v1.4
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                              Entry version: 1

                              Date
                              Changes
                              Submitters
                              Reviewers
                              2015-08-17
                              Submitted
                              • (ID: SCFYH7235HZBUM2XBV52IUHT)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              Detailed domain annotation
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