Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001130.1:
Cluster 1NRP / Polyketide148227

BGC0001130, fabclavine biosynthetic gene cluster from Xenorhabdus budapestensis. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Fabclavine Ia
SMILES string: Copy to clipboard
Molecular formula: C70H126N13O13
Exact molecular mass: 1356.959258 Da (None)
Molecular activity: Antibacterial, Antifungal, Cytotoxic

Class-specific details

Biosynthetic class(es):
NRP / Polyketide
Other (cyclic)
Thioesterase type:
None
Release / cyclization type:
Other

Polyketide subclass:
Other (linear)
Polyketide synthase subclass:
Iterative type I
Starter unit:
Acetoacetyl-CoA
Polyketide synthase / ketosynthase-encoding genes:
Iterative PKS subtype:
Partially reducing
-1
Thioesterase type:
None
Release / cyclization type:
Claisen condensation

Gene cluster description

fabclavine (BGC0001130). Gene Cluster 1. Biosynthetic class = NRP/Polyketide. GenBank Not derived from GenBank. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?unknown
Evidence for cluster-compound connection:Gene expression correlated with compound production
MIxS-compliance:Unknown
Contact for this cluster:Helge B. Bode (Molecular Biotechnology, Institute for Molecular Bioscience, Goethe University Frankfurt, 60438 Frankfurt/Main, Germany)

Literature references

1. Fuchs SW et al. (2014) Fabclavines: bioactive peptide-polyketide-polyamino hybrids from Xenorhabdus. Chembiochem 15(4):512-6. doi: 10.1002/cbic.201300802. Epub 2014 Feb