BGC0001131: ambactin biosynthetic gene cluster from Xenorhabdus miraniensis
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Location: 144,017 - 173,487 nt. (total: 29,471 nt).
This entry is originally from NCBI GenBank NITZ01000005.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001131
Short description ambactin biosynthetic gene cluster from Xenorhabdus miraniensis
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
NITZ01000005.1
144017 - 173487
via Heterologous expression
Compounds
  • ambactin
Species Xenorhabdus miraniensis [taxonomy]
References
Chemical products information
ambactin Evidence:
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C38H54N8O8
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • Xmir_01402
  • PHM49480.1
 144017 - 145486 (-) putative cadaverine/lysine antiporter
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    • Xmir_01403
    • PHM49481.1
    		 145857 - 146810 (-) hypothetical protein
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      • Xmir_01404
      • PHM49482.1
      • pntA
      		 147201 - 148739 (+) NAD transhydrogenase subunit alpha
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        • Xmir_01405
        • PHM49483.1
        		 148750 - 150153 (+) NAD transhydrogenase subunit beta
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          • Xmir_01406
          • PHM49484.1
          		 150281 - 151510 (-) aminoglycosides/tetracycline-transport integral membrane protein
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            • Xmir_01407
            • PHM49485.1
            		 152005 - 171993 (+) Amino acid adenylation
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              • Xmir_01408
              • PHM49486.1
              • rdgB
              		 172386 - 172973 (+) dITP/XTP pyrophosphatase
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                • Xmir_01409
                • PHM49487.1
                		 172990 - 173487 (-) ATPase AAA
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                  Biosynthesis information

                  Biosynthetic modules

                  Name
                  1
                  Type
                  nrps-type1
                  Genes
                  Xmir_01407
                  Substrates
                  serine (evidence: Structure-based inference, Feeding study, Sequence-based prediction)
                  Integrated Monomers
                  Domains
                  adenylation, epimerase
                  Name
                  2
                  Type
                  nrps-type1
                  Genes
                  Xmir_01407
                  Substrates
                  glutamine (evidence: Structure-based inference, Feeding study, Sequence-based prediction)
                  Integrated Monomers
                  Domains
                  condensation (Dual), adenylation
                  Name
                  3
                  Type
                  nrps-type1
                  Genes
                  Xmir_01407
                  Substrates
                  phenylalanine (evidence: Structure-based inference, Feeding study)
                  Integrated Monomers
                  Domains
                  condensation (LCL), adenylation, epimerase
                  Name
                  4
                  Type
                  nrps-type1
                  Genes
                  Xmir_01407
                  Substrates
                  leucine (evidence: Structure-based inference, Feeding study)
                  Integrated Monomers
                  Domains
                  condensation (Dual), adenylation
                  Name
                  5
                  Type
                  nrps-type1
                  Genes
                  Xmir_01407
                  Substrates
                  phenylalanine (evidence: Structure-based inference, Feeding study)
                  Integrated Monomers
                  Domains
                  condensation (LCL), adenylation, epimerase
                  Name
                  6
                  Type
                  nrps-type1
                  Genes
                  Xmir_01407
                  Substrates
                  lysine (evidence: Structure-based inference, Feeding study)
                  Integrated Monomers
                  Domains
                  condensation (Dual), adenylation
                  Annotation changelog

                  Entry version: 4

                  Date
                  Changes
                  Submitters
                  Reviewers
                  2022-10-07
                  Update chemical activity to schema version 2.11
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                  Entry version: 3

                  Date
                  Changes
                  Submitters
                  Reviewers
                  2022-09-15
                  Corrected NRP module activity
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  2022-09-15
                  Corrected gene identifiers
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  2022-09-15
                  Updated NRP substrate specificities
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                  Entry version: 2

                  Date
                  Changes
                  Submitters
                  Reviewers
                  2019-10-16
                  Migrated from v1.4
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  2019-10-16
                  Updated compound(s) information (NPAtlas curation)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                  Entry version: 1

                  Date
                  Changes
                  Submitters
                  Reviewers
                  2015-08-17
                  Submitted
                  • (ID: SCFYH7235HZBUM2XBV52IUHT)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  Detailed domain annotation
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