BGC0001131: ambactin biosynthetic gene cluster from Xenorhabdus miraniensis
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Location: 144,017 - 173,487 nt. (total: 29,471 nt).
This entry is originally from NCBI GenBank NITZ01000005.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001131
Short description ambactin biosynthetic gene cluster from Xenorhabdus miraniensis
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
Loci NCBI GenBank: NITZ01000005.1
Compounds
  • ambactin
Species Xenorhabdus miraniensis [taxonomy]
References
Chemical products information
ambactin
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C38H54N8O8
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • Xmir_01402
  • PHM49480.1
 144017 - 145486 (-) putative cadaverine/lysine antiporter
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  • Xmir_01403
  • PHM49481.1
 145857 - 146810 (-) hypothetical protein
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  • Xmir_01404
  • PHM49482.1
  • pntA
 147201 - 148739 (+) NAD transhydrogenase subunit alpha
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  • Xmir_01405
  • PHM49483.1
 148750 - 150153 (+) NAD transhydrogenase subunit beta
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  • Xmir_01406
  • PHM49484.1
 150281 - 151510 (-) aminoglycosides/tetracycline-transport integral membrane protein
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  • Xmir_01407
  • PHM49485.1
 152005 - 171993 (+) Amino acid adenylation
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  • Xmir_01408
  • PHM49486.1
  • rdgB
 172386 - 172973 (+) dITP/XTP pyrophosphatase
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  • Xmir_01409
  • PHM49487.1
 172990 - 173487 (-) ATPase AAA
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NRP-specific information
Subclass N/A
Cyclic? yes
Release type
  • Macrolactamization
NRP-synthases
Gene Modules
Xmir_01407
Module 1
Specificity: serine
Evidence for specificity:
  • Structure-based inference
  • Feeding study
  • Sequence-based prediction
Module 2
Specificity: glutamine
Evidence for specificity:
  • Structure-based inference
  • Feeding study
  • Sequence-based prediction
Condensation domain type: Dual
Module 3
Specificity: phenylalanine
Evidence for specificity:
  • Structure-based inference
  • Feeding study
Condensation domain type: LCL
Module 4
Specificity: leucine
Evidence for specificity:
  • Structure-based inference
  • Feeding study
Condensation domain type: Dual
Module 5
Specificity: phenylalanine
Evidence for specificity:
  • Structure-based inference
  • Feeding study
Condensation domain type: LCL
Module 6
Specificity: lysine
Evidence for specificity:
  • Structure-based inference
  • Feeding study
Condensation domain type: Dual
Annotation changelog
MIBiG version Submitter Notes
1.1
  • Hidden contributor (ID: SCFYH7235HZBUM2XBV52IUHT, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Corrected NRP module activity
  • Corrected gene identifiers
  • Updated NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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