Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001131.1:
Cluster 1NRP129471

BGC0001131, ambactin biosynthetic gene cluster from Xenorhabdus miraniensis. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Ambactin
SMILES string: Copy to clipboard
Molecular formula: C38H55N8O8
Exact molecular mass: 751.413737 Da ([M+H]+)
Molecular activity: Other

Class-specific details

Biosynthetic class(es):
NRP
Other (cyclic)
Thioesterase type:
Type I
Release / cyclization type:
Macrolactamization

Nonribosomal peptide synthetases:
-
Module 1
A specificity: Serine
Evidence for specificity: Structure-based inference
AA is epimerized
C domain subtype: None
Module 2
A specificity: Glutamine
Evidence for specificity: Structure-based inference
C domain subtype: Dual
Module 3
A specificity: Phenylalanine
Evidence for specificity: Structure-based inference
AA is epimerized
C domain subtype: LCL
Module 4
A specificity: Leucine
Evidence for specificity: Structure-based inference
C domain subtype: Dual
Module 5
A specificity: Phenylalanine
Evidence for specificity: Unknown
AA is epimerized
C domain subtype: LCL
Module 6
A specificity: Lysine
Evidence for specificity: Structure-based inference
C domain subtype: Dual

Gene cluster description

ambactin (BGC0001131). Gene Cluster 1. Biosynthetic class = NRP. GenBank Not derived from GenBank. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?unknown
Evidence for cluster-compound connection:Heterologous expression
MIxS-compliance:Unknown
Contact for this cluster:Helge B. Bode (Molecular Biotechnology, Institute for Molecular Bioscience, Goethe University Frankfurt, 60438 Frankfurt/Main, Germany)

Literature references

1. Schimming O et al. (2014) Yeast homologous recombination cloning leading to the novel peptides ambactin and xenolindicin. Chembiochem 15(9):1290-4. doi: 10.1002/cbic.201402065. Epub 2014 May