BGC0001132 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001132 (Xenorhabdus nematophila ATCC 19061)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	12,417	xenotetrapeptide	NRPS:Type I	100%

BGC0001132 - Region 1 - NRPS

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Location: 1 - 12,417 nt. (total: 12,417 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 12,418
Label		BGC0001132

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001132	1.00	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0002286	0.39	NRP	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128	0.39	NRP	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135	0.36	NRP	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0002135	0.32	NRP	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001641	0.32	NRP	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758	0.32	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001833	0.32	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0002518	0.31	NRP	syringafactin A, syringafactin C	Pseudomonas sp. SZ57
BGC0001844	0.31	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001132	1.00	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0002286	0.71	NRP	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128	0.71	NRP	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135	0.68	NRP	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0002135	0.66	NRP	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001641	0.66	NRP	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758	0.65	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001833	0.65	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0002518	0.65	NRP	syringafactin A, syringafactin C	Pseudomonas sp. SZ57
BGC0001844	0.64	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 12417:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Val - Leu - Val - Val)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

XNC1_2022

Search NORINE for peptide: strict or relaxed

AMP-binding (64..463): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: DAFWIGGTFK
Nearest Stachelhaus code(s):: Val DAFWIGGTFK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1140..1534): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAWCIGAVCK
Nearest Stachelhaus code(s):: Leu DAWCIGAVCK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2191..2595): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: DAFWIGGTFK
Nearest Stachelhaus code(s):: Val DAFWIGGTFK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (3271..3675): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: DAFWIGGTFK
Nearest Stachelhaus code(s):: Val DAFWIGGTFK (100% 8Å match)
Stachelhaus code match:: 100% (strong)