Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001132.1:
Cluster 1NRP112417

BGC0001132, xenotetrapeptide biosynthetic gene cluster from Xenorhabdus nematophila. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Xenotetrapeptide
SMILES string: Copy to clipboard
Molecular formula: C21H39O4N4
Exact molecular mass: 411.296582 Da ([M+H]+)
Molecular activity: Unknown

Class-specific details

Biosynthetic class(es):
NRP
Other (cyclic)
Thioesterase type:
Type I
Release / cyclization type:
Macrolactamization

Nonribosomal peptide synthetases:
xnc1_2022
Module 1
A specificity: Valine
Evidence for specificity: Structure-based inference
AA is epimerized
C domain subtype: LCL
Module 2
A specificity: Leucine
Evidence for specificity: Structure-based inference
C domain subtype: Dual
Module 3
A specificity: Valine
Evidence for specificity: Structure-based inference
AA is epimerized
C domain subtype: LCL
Module 4
A specificity: Valine
Evidence for specificity: Structure-based inference
C domain subtype: Dual

Gene cluster description

xenotetrapeptide (BGC0001132). Gene Cluster 1. Biosynthetic class = NRP. GenBank FN667742, positions 1902220-1914421. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies, Heterologous expression
MIxS-compliance:Yes
Contact for this cluster:Helge B. Bode (Molecular Biotechnology, Institute for Molecular Bioscience Goethe University Frankfurt, 60438 Frankfurt/Main, Germany)

Literature references

1. Kegler C et al. (2014) Rapid determination of the amino acid configuration of xenotetrapeptide. Chembiochem 15(6):826-8. doi: 10.1002/cbic.201300602. Epub 2014 Mar