BGC0001133 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001133 (Xenorhabdus bovienii SS-2004)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	25,888	taxlllaid A	NRPS:Type I	100%

BGC0001133 - Region 1 - NRPS

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Location: 1 - 25,888 nt. (total: 25,888 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 25,889
Label		BGC0001133

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001133	1.00	NRP	taxlllaid A	Xenorhabdus bovienii SS-2004
BGC0002071	0.40	NRP	virginiafactin A, virginiafactin B, virginiafactin C, virginiafactin D	Pseudomonas sp. QS1027
BGC0001825	0.40	NRP	xenematide	Xenorhabdus nematophila AN6/1
BGC0001834	0.37	NRP	argyrin	Cystobacter sp. SBCb004
BGC0002691	0.36	NRP	amphibactin B, amphibactin C, amphibactin D, amphibactin E, amphibactin H, amphibactin S, amphibactin T, amphibactin V	Vibrio neptunius
BGC0001846	0.34	Saccharide, NRP	valinomycin, montanastatin	Streptomyces sp. CBMAI 2042
BGC0002135	0.34	NRP	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0002465	0.34	NRP	amphibactin E, amphibactin H, amphibactin I	Alcanivorax borkumensis SK2
BGC0002437	0.34	NRP	thermoactinoamide A	Thermoactinomyces sp. AS95
BGC0002518	0.33	NRP	syringafactin A, syringafactin C	Pseudomonas sp. SZ57

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001133	1.00	NRP	taxlllaid A	Xenorhabdus bovienii SS-2004
BGC0002071	0.72	NRP	virginiafactin A, virginiafactin B, virginiafactin C, virginiafactin D	Pseudomonas sp. QS1027
BGC0001825	0.72	NRP	xenematide	Xenorhabdus nematophila AN6/1
BGC0001834	0.69	NRP	argyrin	Cystobacter sp. SBCb004
BGC0002691	0.69	NRP	amphibactin B, amphibactin C, amphibactin D, amphibactin E, amphibactin H, amphibactin S, amphibactin T, amphibactin V	Vibrio neptunius
BGC0001846	0.67	Saccharide, NRP	valinomycin, montanastatin	Streptomyces sp. CBMAI 2042
BGC0002135	0.67	NRP	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0002465	0.67	NRP	amphibactin E, amphibactin H, amphibactin I	Alcanivorax borkumensis SK2
BGC0002437	0.67	NRP	thermoactinoamide A	Thermoactinomyces sp. AS95
BGC0002518	0.67	NRP	syringafactin A, syringafactin C	Pseudomonas sp. SZ57

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 25888:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Thr - Ser - Leu - D-Leu) + (D-Leu - Leu - Ser)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

XBJ1_0774

Search NORINE for peptide: strict or relaxed

AMP-binding (553..954): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: leu (Leu)

Stachelhaus prediction details:

Stachelhaus sequence:: DAFFHGQVCK
Nearest Stachelhaus code(s):: Leu DAFFHGQVCK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2047..2448): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: leu (Leu)

Stachelhaus prediction details:

Stachelhaus sequence:: DAFFHGQVCK
Nearest Stachelhaus code(s):: Leu DAFFHGQVCK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (3092..3509): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: ser (Ser)
Single AA prediction:: ser (Ser)

Stachelhaus prediction details:

Stachelhaus sequence:: DVWHFSLIEK
Nearest Stachelhaus code(s):: Ser DVWHFSLIEK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

XBJ1_0775

Search NORINE for peptide: strict or relaxed

AMP-binding (467..889): Thr

nrpys: Thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: DFWNIGMVHK
Nearest Stachelhaus code(s):: Thr DFWNIGMVHK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1533..1950): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: ser (Ser)
Single AA prediction:: ser (Ser)

Stachelhaus prediction details:

Stachelhaus sequence:: DVWHFSLIEK
Nearest Stachelhaus code(s):: Ser DVWHFSLIEK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2594..2995): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: leu (Leu)

Stachelhaus prediction details:

Stachelhaus sequence:: DAFFHGQVCK
Nearest Stachelhaus code(s):: Leu DAFFHGQVCK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (3639..4040): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: leu (Leu)

Stachelhaus prediction details:

Stachelhaus sequence:: DAFFHGQVCK
Nearest Stachelhaus code(s):: Leu DAFFHGQVCK (100% 8Å match)
Stachelhaus code match:: 100% (strong)