Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001135.1:
Cluster 1NRP116848

BGC0001135, bicornutin biosynthetic gene cluster from Xenorhabdus budapestensis. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Bicornutin A1
SMILES string: Copy to clipboard
Molecular formula: C34H72O5N19
Exact molecular mass: 826.5958 Da ([M+H]+)
Molecular activity: Antibacterial

Class-specific details

Biosynthetic class(es):
NRP
Other (linear)
Thioesterase type:
Unknown
Release / cyclization type:
Unknown

Nonribosomal peptide synthetases:
BicA (AFP87549)
Module 1
A specificity: Arginine
Evidence for specificity: Other
AA is epimerized
C domain subtype: Unknown
Module 2
A specificity: Leucine
Evidence for specificity: Other
C domain subtype: Unknown
Module 3
A specificity: Arginine
Evidence for specificity: Other
AA is epimerized
C domain subtype: Unknown
Module 4
A specificity: Arginine
Evidence for specificity: Other
AA is epimerized
C domain subtype: Unknown
Module 5
A specificity: Arginine
Evidence for specificity: Other
C domain subtype: Unknown

Gene cluster description

bicornutin (BGC0001135). Gene Cluster 1. Biosynthetic class = NRP. GenBank JX424818. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Heterologous expression
MIxS-compliance:Unknown
Contact for this cluster:Helge Bode (Goethe Universitaet Frankfurt)

Literature references

1. Fuchs SW et al. (2012) Neutral loss fragmentation pattern based screening for arginine-rich natural products in Xenorhabdus and Photorhabdus. Anal Chem 84(16):6948-55. doi: 10.1021/ac300372p. Epub 2012 Aug 6.