Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001136.1:
Cluster 1NRP / Polyketide120147

BGC0001136, desmethylbassianin biosynthetic gene cluster from Beauveria bassiana. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: desmethylbassianin
SMILES string: Copy to clipboard
Molecular formula: C22H23NO5
Exact molecular mass: 381.1576 Da (M+)
Molecular activity: Unknown

Class-specific details

Biosynthetic class(es):
NRP / Polyketide
Other (linear)
Thioesterase type:
None
Release / cyclization type:
Other

Nonribosomal peptide synthetases:
dmbS (DMBS)
Module 2
A specificity: Tyrosine
Evidence for specificity: Structure-based inference
C domain subtype: Other
Module is non-elongating
Evidence for non-elongation: Unknown
Polyketide subclass:
Other (linear)
Polyketide synthase subclass:
Iterative type I
Starter unit:
Acetyl-CoA
Polyketide synthase / ketosynthase-encoding genes:
Iterative PKS subtype:
Highly reducing
Number of iterations:
5
Other
Thioesterase type:
None
Release / cyclization type:
Other

Modular polyketide synthases:
dmbS (DMBS)
Module 1
AT specificity: Acetyl-CoA + Malonyl CoA
Evidence for specificity: None
KR stereochemistry: Unknown
Scaffold-modifying domain: None
Module is iterated
Evidence for iteration: Unknown

Gene cluster description

desmethylbassianin (BGC0001136). Gene Cluster 1. Biosynthetic class = NRP/Polyketide. GenBank HM243222. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Heterologous expression
MIxS-compliance:Unknown
Contact for this cluster:Russell Cox (Institut fuer Organische Chemie, Leibniz Universitaet Hannover)

Literature references

1. Fisch KM et al. (2011) Rational domain swaps decipher programming in fungal highly reducing polyketide synthases and resurrect an extinct metabolite. J Am Chem Soc 133(41):16635-41. doi: 10.1021/ja206914q. Epub 2011