LOCUS       BGC0001137             18476 bp    DNA     linear   BCT 22-MAY-2013
DEFINITION  Marinactinospora thermotolerans strain SCSIO 00652 marinacarbolines
            gene cluster, complete sequence.
ACCESSION   BGC0001137
VERSION     BGC0001137
KEYWORDS    .
SOURCE      Marinactinospora thermotolerans
  ORGANISM  Marinactinospora thermotolerans
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Nocardiopsaceae; Marinactinospora.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 14:58:54
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..3744
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1134:flavodoxin (Score: 176.5; E-value: 1.3e-53)"
                     /gene_kind="biosynthetic-additional"
                     /note="Orf-7"
                     /product="nitrate reductase subunit alpha"
                     /protein_id="AGL76713.1"
                     /transl_table=11
                     /translation="MRGTGKEPGQSGDPADLLLKAGVYLTRSKSSRDLRVVFKDGGREG
                     DVFYRDRWSHDKVVRSTHGVNCTGSCSWNVYVKDGIITWETQATDYPSVGPDRPEYEPR
                     GCPRGAAFSWYTYSPTRVRYPYARGVLVEMFREARARSGDPVAAWAEITADPVRRRRYQ
                     GARGKGGLVRVSWEEAVEMVAAAHVHTIREFGPDRVAGFSPIPAMSQVSQGVGARFVNL
                     LGGSMLSFYDWYADLPVASPQVFGDQTDVPESGDWWDAAYLVVWGSNVPVTRTPDAHWM
                     AEARYRGQKVVVVSPDYSDASKFADEWLAPHPGTDGALAMAMGHVVLRERFVEKRTPAF
                     ESYVKKYTDLPFLVALDEQDGRWVPGRFVTAADVEGVAGAPPGDPDGTWKPVFVDEASG
                     EVVAPNGTLGHRWGEAGRGRWNLDLQGRDPLLSFHGREGAEAVEVLLPRFDLDEADETT
                     GASTPPGAGRVIARGVPIRRIGGKAVTTVFDLLLAQYGVGRAGLPGEWPRDYDDASLPY
                     TPAWQEEITSVPAATAVRIAREFADTAERSGGRAMIILGAGVNQWFHGDTMYRAFLTLL
                     LLTGCQGVNGGGWAHYVGQEKCRTHTGWATYAAASDWTRPPRFMPGTAYWYMHTDQWRY
                     DAYDADALTAPTGPGRLAGRHTADLVAASARMGWMPSYPTFDRNPIELGKEAKAAGRDP
                     AEYVVDQLGSGKLRFAAEDPDAPENWPRVLTVWRANLLGSSAKGNEYFLRHLLGADSAV
                     QGAEAGPGSRPSEVVWRDEAPQGKLDLLVSLDFRMTSTTLLSDVVLPAATWYEKYDLST
                     TDMHPFVHAFAPAIDPPWQARTDFDAFHAIAKRFSELAERHLGVVTDVVAVPPQHDTPG
                     ELAQPGGTAPDWKRDGQIPVPGRTMPDLIPVERDYPAVAEKMAAVGPLAETKGLPVKGV
                     SFTPDKEIAWLGQRNGVVSGGVADGRPLLDTDVKVCEMILALSGTSNGRLASQGFERLA
                     ERTGTDLSELIEGGRERRVVFADTRTRPTPVGASPEWSGKEAVDRRYAPFTINVEHDKP
                     WHTLTGRQHFYLDHEWMREFGGVLPVYRPPLDAHRLFGEPELGPRGQREVTVRYLTPHS
                     KWSIHSEYQDNLLMLTLSRGGPTIWMSPADAEVIGARDNDWVEAVNRNGVVAARLVVSH
                     RMPAGTVYMYHAQERLVAVPKTETTGRRGGIHNSLTRLLVKPTHLIGGYAQFAYGFNYI
                     GPTGNQRDEVTVVRKRVAEVRY"
     source          1..18476
                     /db_xref="taxon:531310"
                     /isolation_source="deep sea marine sedmient of South China
                     Sea"
                     /mol_type="genomic DNA"
                     /organism="Marinactinospora thermotolerans"
                     /strain="SCSIO 00652"
                     /type_material="type strain of Marinactinospora
                     thermotolerans"
     misc_feature    1..18476
                     /note="marinacarbolines gene cluster"
     subregion       1..18476
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0001137"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..18476
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     CDS             3891..5612
                     /codon_start=1
                     /note="Orf-6"
                     /product="nitrate reductase subunit beta"
                     /protein_id="AGL76714.1"
                     /transl_table=11
                     /translation="MEIRDGAGRPIGRVMAQVAMVMNLDKCIGCHTCSVTCKQAWTNRS
                     GVEYVWFNNVETRPGQGYPRQYEDQERWRGGWRRTGSGRLVPRAGGRLHKLATIFANPL
                     MPSIQDYYEPWTYDYENLIVAPLGDDMPVARPRSLISGEPMNIEWSANWDDNLGGGPEV
                     AGGDPLARRLGEKVRFSFEESFMFYLPRICEHCLNPSCVASCPSGALYKRSEDGIVLVD
                     QDRCRGWRMCVTGCPYKKVYFNHKTGKAEKCTLCYPRVEVGLPTVCSETCVGRLRYLGV
                     VLYDAERVGQAAAVADERDLYPAQLDVMLDPEDEGVRAAARRDGIAERWVESARRSPVY
                     TLAARYRVALPLHPEYRTLPMVWYVPPLSPVVDALVETGHDGEAAGNLFGAIEALRIPV
                     EYLAELFTAGDVEPVVGALRRLAAMRSHMRRVNLGEPVDEGIAEAVGMRTAEIEAMYRL
                     LAVAKYDERYVIPTAYGVDEADRGVIEEVGCSLDFEGGPGTGGMGGAAPWGEASGRARP
                     ATVENFHALRVRQSGEKPSGSAKRVNLLNWDGRGRPEGLFPKKRKDGAEAAEEGTE"
     CDS             5848..6327
                     /codon_start=1
                     /note="Orf-5"
                     /product="nitrate reductase delta subunit"
                     /protein_id="AGL76715.1"
                     /transl_table=11
                     /translation="MHYVEAFDMRGKRTPHMTFYLDGDTRRRGHTLAAIKEIYTGCGWE
                     LSPRELPDHLAVILEFAARGDAEWGETLLHYFRPGLDLLGAALHEYATPYAAVLDAVRA
                     TLPPPGPEQEEAVRRLARLGPPAEAVGLDGYGGPVDLGMPGVGSPVNSGILGGAR"
     CDS             6324..7064
                     /codon_start=1
                     /note="Orf-4"
                     /product="respiratory nitrate reductase subunit gamma"
                     /protein_id="AGL76716.1"
                     /transl_table=11
                     /translation="MTWLDYALWGVLPYLVLLVLVGGTVWRYRYDRFGWTTRSSQLYES
                     RLLRIASPMFHFGLLVVIVGHVIGLLIPKSWTEAVGIPESAYHLTALSLGIVAGVCTLG
                     GIALLIWRRRTTGPVFSATTVNDKIMYLVLTMAIVAGLATTLLSAGADLTGGHGHDYRE
                     TVSVWFRSIWILQPDVAAMAASTFAFKLHVVIGLALFTLLPFTRLVHAFTAPVGYLFRP
                     YVVYRARDPRSTTRTSRPIRRGWG"
     CDS             7245..8774
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222:dehydrogenase (Score: 144; E-value: 1.3e-43)"
                     /gene_kind="biosynthetic-additional"
                     /note="Orf-3"
                     /product="FAD dependent oxidoreductase"
                     /protein_id="AGL76717.1"
                     /transl_table=11
                     /translation="MEPSGPSPRCPPASAPGRGSHPAGGGEMGDIDAVVVGTGPNGLAA
                     AVTLARAGLKVELYERHDVIGGGLRTVPLFDSDVVHDVCAAVHPMAAASRFFREFDLVA
                     RGVDLLRPAVSYAHPLPHGRAALAAADLDATCAGLGEDARRWRRLMAPLVARSGAVVDL
                     LLSDLRRLPADPVAALSFARRVLQHGRGTGPFVTDGARALLAGVAGHVVGALPSLPGAA
                     VALLLGHLAHTDAGWPLPRGGSGVIAEALAADITAHGGVLRTGHEIRDLGDLPPARSVL
                     LDVAPRGFLRLAGDRLPPRYRRALRRFRYAPGVAKADFLVSEPIPWTAREVAGAGTVHL
                     GGTQEQVFRVETATARGRRTDEPFVLLVDPAVTDPSRASGGRRPVWAYAHVPNGDTRDP
                     VDMIRRRIETYAPGFSDTIIASRGVSAAEMEAYNPNYVGGDIASGAMTLRQALIRPTPR
                     IDPYRTPLPGVYLCSASVPPGPGVHAMSGYLAALSALRNDHGVTVPPSLSP"
     CDS             complement(8827..10764)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1053:beta-lactamase (Score: 136.4; E-value: 2.1e-41)"
                     /gene_kind="biosynthetic-additional"
                     /note="Orf-2"
                     /product="beta-lactamase"
                     /protein_id="AGL76718.1"
                     /transl_table=11
                     /translation="MPRTRDVALGVLCVALVCGSVLGGAAGDANAATAQGGGHAHPPAT
                     TGPEDRAALEELIDDLARGHVGHTTPGAMIAVVDADGPLVLDARGQADPMRGVPLTVDS
                     RTPVASVSKVVTALTALSLHHQGSLDLDAEIGSLAGVTLRDRRAPAARTPVTGRHLLTH
                     HSGLEEPLLLHPDPPDDANQVARSLRSWLDEHPPTLRHPADVGLHYSPLQGYTLIGAAI
                     EQATGRPFDQAAREHVLEPVGARDAGFGATEPADGDVVLTAPDDTGWTASPWPAVHEAP
                     SASLTWSTRDAAALLHALLADNGRLSPEVVAEATTTAVRPAHGGDGHTQVFFETWREGV
                     RVLEHAGGNGVAWLALLPEAGLGVFAAVTSDTADAMPFAPAVVDAVARWAVATGRVAAA
                     PEPQAGRPTVVPPWAGDLAPAVPVGTFHERLFAGRGPELALRSLTGQVTVTRDGEDLLL
                     GERRFAPAAPGRWCDPHGCIAGVRSADGAVFLLRGDRKMLEQTLAPAPWWARRGFTVTA
                     LAGVLVLSVAAVCAVVRARARGRRGTAARASRRLGLAWVLLAVGVAVAAPMMALSPLVT
                     GGAWVPAGGAAVWVLRLATAAGLAVGVGWAVTVVVRWRGAGAPRRVAAVAAFLAGAIAQ
                     LTLLTWALPS"
     CDS             10842..11543
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057:TetR family
                     transcriptional regulator (Score: 73.3; E-value: 5.8e-22)"
                     /gene_kind="regulatory"
                     /note="Orf-1"
                     /product="TetR family transcriptional regulator"
                     /protein_id="AGL76719.1"
                     /transl_table=11
                     /translation="MPHRVDHDARRSRLVEAAMRVVATDGFAAVSVRRVAAEAGHSPGS
                     LRYFFPTQESLIEAALAHVTELAAERLVGRIVAFENADAGRVVDAACALIEELLPLDET
                     RRAEWRIYGALSEPSVATSALARWRKAGWAGTRHQCRRVVRGLTGGGVNGAAARVADPP
                     PDAEAILAAAERLAASPDDTVEQRAAGLHALIDGLGAQLVQFPDMVTERAARATVRRAV
                     TDLARVLSPDL"
     CDS             11893..13380
                     /NRPS_PKS="Domain: AMP-binding (12-399). E-value: 1.1e-80.
                     Score: 263.0. Matches aSDomain:
                     nrpspksdomains_AGL76720.1_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     327.4; E-value: 2.1e-99)"
                     /gene_kind="biosynthetic-additional"
                     /note="McbA"
                     /product="fatty acid CoA ligase"
                     /protein_id="AGL76720.1"
                     /sec_met_domain="AMP-binding (E-value: 5.4e-88, bitscore:
                     285.0, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGYARRVMDGIGEVAVTGAGGSVTGARLRHQVRLLAHALTEAGIP
                     PGRGVACLHANTWRAIALRLAVQAIGCHYVGLRPTAAVTEQARAIAAADSAALVFEPSV
                     EARAADLLERVSVPVVLSLGPTSRGRDILAASVPEGTPLRYREHPEGIAVVAFTSGTTG
                     TPKGVAHSSTAMSACVDAAVSMYGRGPWRFLIPIPLSDLGGELAQCTLATGGTVVLLEE
                     FQPDAVLEAIERERATHVFLAPNWLYQLAEHPALPRSDLSSLRRVVYGGAPAVPSRVAA
                     ARERMGAVLMQNYGTQEAAFIAALTPDDHARRELLTAVGRPLPHVEVEIRDDSGGTLPR
                     GAVGEVWVRSPMTMSGYWRDPERTAQVLSGGWLRTGDVGTFDEDGHLHLTDRLQDIIIV
                     EAYNVYSRRVEHVLTEHPDVRAAAVVGVPDPDSGEAVCAAVVVADGADPDPEHLRALVR
                     DHLGDLHVPRRVEFVRSIPVTPAGKPDKVKVRTWFTD"
     aSDomain        11929..13089
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AGL76720.1_AMP-binding.1"
                     /evalue="1.10E-80"
                     /label="AGL76720.1_AMP-binding.1"
                     /locus_tag="AGL76720.1"
                     /protein_end="399"
                     /protein_start="12"
                     /score="263.0"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="EVAVTGAGGSVTGARLRHQVRLLAHALTEAGIPPGRGVACLHANT
                     WRAIALRLAVQAIGCHYVGLRPTAAVTEQARAIAAADSAALVFEPSVEARAADLLERVS
                     VPVVLSLGPTSRGRDILAASVPEGTPLRYREHPEGIAVVAFTSGTTGTPKGVAHSSTAM
                     SACVDAAVSMYGRGPWRFLIPIPLSDLGGELAQCTLATGGTVVLLEEFQPDAVLEAIER
                     ERATHVFLAPNWLYQLAEHPALPRSDLSSLRRVVYGGAPAVPSRVAAARERMGAVLMQN
                     YGTQEAAFIAALTPDDHARRELLTAVGRPLPHVEVEIRDDSGGTLPRGAVGEVWVRSPM
                     TMSGYWRDPERTAQVLSGGWLRTGDVGTFDEDGHLHLTDRLQDIIIV"
     CDS_motif       12349..12405
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AGL76720.1_0001"
                     /evalue="4.90E-07"
                     /label="NRPS-A_a3"
                     /locus_tag="AGL76720.1"
                     /protein_end="171"
                     /protein_start="152"
                     /score="22.2"
                     /tool="antismash"
                     /translation="AVVAFTSGTTGTPKGVAHS"
     CDS_motif       12907..12990
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AGL76720.1_0002"
                     /evalue="7.80E-09"
                     /label="NRPS-A_a6"
                     /locus_tag="AGL76720.1"
                     /protein_end="366"
                     /protein_start="338"
                     /score="27.9"
                     /tool="antismash"
                     /translation="PRGAVGEVWVRSPMTMSGYWRDPERTAQ"
     CDS             13464..14408
                     /codon_start=1
                     /note="McbB"
                     /product="cucumopine synthase"
                     /protein_id="AGL76721.1"
                     /transl_table=11
                     /translation="MRQIEIEWVQPGITVTADLSWERNPELAELLWTGLLPYNSLQNHA
                     LVSGNHLYHLIADPRLVYTEARYKEDRTKSPDGTVFLSQLQHLAVKYGPLTEYLPAAPV
                     GSVVPEDIDALREAGRACWKAAWETKQPIEVRVRRKGEAVTDFALPRTPPVDHPGVQKL
                     VEEIQDETERVWITPPAEIVDMHQGRIASRAGSYDQYFSTLVFLNGEVRPLGYCALNGL
                     LKICRTTDLTLNDLKRITPTFIKTPAEFLGYTGLDTLWRFTQQVLTLLPDVETREQYFA
                     LVNALALYANMLNTWNLHFFPWQHGTDYRYLDA"
     CDS             14462..16114
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1180:Decarboxylase, pyridoxal-dependent (Score: 155.7;
                     E-value: 2.6e-47)"
                     /gene_kind="biosynthetic-additional"
                     /note="McbC"
                     /product="glutamate decarboxylase"
                     /protein_id="AGL76722.1"
                     /transl_table=11
                     /translation="MRRRMLRPDEQNRDELRERIGVLFSGLPRDTPADDSWLGTATPDY
                     GWLRAFEHIPRTGADRDLVLGAVAAALNGQLRQHSLGTFFNLMPLPLLDAVAAAAVTDL
                     YSPNALWDLVSSGVLDVERQIVRQLAGLAGWRPELAGGTFSFGGKAGLIYAIRLGLNRC
                     RPEASRRGLAGGPAPVVITTGHNHDSVEMACSLLGLGTEACLRVPVAPGRAVSPRAVEE
                     TVAGLVARGVPIACVVLSGGNILHNAMDPVHEVADALTRTCRGLSYRPYLHFDTAFGWP
                     WLFFGDYDFAGNPLGIEEGVLARIEQSTRLVTGVEAADSMTADFHKIGFCPYSSSVFLA
                     KEDAELRSLHGETTTPREGAWGDTLVLHHTIEHSRSGAGILAAWVALQSVGRTGFQVYL
                     AHMIAISDVFRSLLPGGGYELLNPWATGPTAVYWPVPPGGPDRFADLRGGDSSPLIERA
                     NRYTHALYRRLAGLDGKAGASRITLGLLPTYERSARGEPIAALRLLPTSLHHDHSRTAE
                     LAGRMVEVKKELDKTVERGSGWLPDARLYPVPE"
     misc_feature    14603..14605
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     CDS             complement(16361..17242)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1199:NmrA family
                     protein (Score: 237.4; E-value: 3.7e-72)"
                     /gene_kind="other"
                     /note="Orf+1"
                     /product="NAD(P)H azoreductase"
                     /protein_id="AGL76723.1"
                     /transl_table=11
                     /translation="MTPPGKDTPMNTPTVLVTGATGTVGSALVPALRARGATVRAMVRD
                     AGRAVPGVENVVADLNDPRAVATAVQGVDAVFLNSPSAQDAAALQIRFADLARDAGVSR
                     LVLLSQYAARVDSPVRFLRWHAEVEAHVRRLGLDHTVLRPNLYMQALLGFAGTIAQGWF
                     AAPIGDAAVSVIDTRDIAETAAVVLTTSGHTGRTYTLTGPRAVTHGQIAQALSTATGRE
                     ITFQEVPDEQFAAALTGLMPPWQLDGLVEDYAHYARGEAAEVYSCVTDLTGRPARDITD
                     FARDHAAMFAQT"
     CDS             complement(17239..17892)
                     /codon_start=1
                     /note="Orf+2"
                     /product="putative drug resistance transporter"
                     /protein_id="AGL76724.1"
                     /transl_table=11
                     /translation="MTTHSQRENCDRPGTSRRERVTTAPTVEANTRWKDGPMSAPTTPP
                     TADTRPRPRVPRAVAGLATSMFLIVLTTAMIDLAEPAIREDLGLSTAELTLVVNGYLIA
                     FAGLLLGGRLGAVTATSMALHDTGEGESGVLSGLVNAVQRLGGAIGLAALAGIAIGTAG
                     TSGGIAFTTVLLGQSVLVVVSLVLALLPLSHPRMPPAAAGPSCPSITPSSNRPR"
     CDS             complement(17928..18476)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057:TetR family
                     transcriptional regulator (Score: 74.7; E-value: 2.2e-22)"
                     /gene_kind="regulatory"
                     /note="Orf+3"
                     /product="TetR family transcriptional regulator"
                     /protein_id="AGL76725.1"
                     /transl_table=11
                     /translation="MPGGRRPRVSFERRREQILAAALKEFSHKGLHGGSTVNIAKAVEI
                     SHPNLFRVFSTKKELFIAVLEQTFETIAQEMLVPGEAAERDPLQTMADAWGSLMERREL
                     MLILLQGYAACEDPDIRDLMHRWTQDVFERLEVLPEVGTDPAHDFFAAGMLYMVAASMD
                     LPARAEHDEWAKRFLDSGS"
ORIGIN
        1 atgcgtggaa ccggtaaaga accaggacag agcggtgatc ctgcggatct tctgctcaag
       61 gccggggttt atctgacaag gtcgaagtca tcaagggacc ttcgggtcgt ttttaaggac
      121 ggaggtcgcg agggtgacgt tttctatcgt gatcgatgga gccatgacaa ggtcgtgcgg
      181 tcgacgcatg gggtgaattg cacggggtcg tgttcgtgga atgtatatgt gaaggacggg
      241 attatcacgt gggagacgca ggccacggat tatccgtcgg tggggccgga ccgcccggag
      301 tatgagccgc gggggtgccc gcggggggcg gcgttctcct ggtacacgta ctcgccgacg
      361 cgggtgcgct atccgtatgc gcgcggggtg ctggtggaga tgttccggga ggcgcgggcg
      421 cggtcggggg acccggtggc ggcgtgggcg gagatcacgg ccgatccggt acggcgccgg
      481 cgctaccagg gggcgcgggg caagggggga ctggtccggg tctcctggga ggaggccgtg
      541 gagatggtgg cggcggccca tgtgcacacg atccgggagt tcggtccgga ccgggtggcg
      601 gggttctcac cgattccggc gatgtcgcag gtgtcgcagg gggtgggggc gcggttcgtg
      661 aacctgctgg gcgggtcgat gttgtcgttc tatgactggt acgcggatct gccggtggcg
      721 tcgccgcagg tgttcgggga ccagacggac gtgccggagt cgggcgactg gtgggacgcg
      781 gcctatctgg tggtgtgggg gtccaacgtg ccggtgacgc gcacgccgga tgcgcactgg
      841 atggccgagg cgcggtatcg ggggcagaag gtcgtggtgg tgtcgccgga ttacagcgac
      901 gcgtcgaagt tcgccgacga gtggctggcg ccacatccgg ggaccgacgg ggcgctggcg
      961 atggcgatgg ggcacgtggt gctgcgggag cggttcgtgg agaagcggac cccggcattc
     1021 gagtcgtatg tgaagaagta caccgacctg ccgttcctgg tggccctgga cgagcaggac
     1081 gggaggtggg tgcccggacg gttcgtgacg gcggcggatg tggaaggggt ggccggggcg
     1141 ccgcccgggg acccggacgg gacgtggaag ccggtgttcg tggacgaggc gtcgggggag
     1201 gtggtggcgc cgaacgggac gttgggacac cggtgggggg aggccgggcg ggggcggtgg
     1261 aatctggacc tgcagggacg ggacccactg ctgagcttcc atggccggga gggggccgag
     1321 gcggtggagg tgctcctccc ccgattcgac ctcgacgagg ccgacgagac cacgggcgcg
     1381 tcgacaccgc cgggagccgg gcgggtcatc gcccggggcg tcccgatccg ccggatcggc
     1441 ggaaaagcgg tgaccacggt gttcgatctg ctgctggccc agtacggggt ggggcgcgcg
     1501 gggctgccgg gggagtggcc acgggactac gacgacgcct cgctgcccta cacgccggcg
     1561 tggcaggagg agatcacctc ggttccggcg gccacggcgg tgcggatcgc gcgggagttc
     1621 gccgacacgg ccgagcggtc gggcgggcgg gcgatgatca tcctgggcgc cggggtgaac
     1681 cagtggttcc acggcgacac gatgtatcgg gcgttcctca cgttgctgct gctgaccggc
     1741 tgtcaggggg tgaacggagg agggtgggcg cactacgtgg gccaggagaa gtgccgcacc
     1801 cacaccggct gggccaccta tgccgcggcc tccgactgga cccggccgcc gcgcttcatg
     1861 ccgggcacgg cctactggta catgcacacc gaccagtggc gttacgacgc ctatgacgcc
     1921 gacgccctga ccgcgccgac cgggccgggc aggctcgcgg gcaggcacac cgccgatctg
     1981 gtggcggcct cggcgcggat gggctggatg ccctcctacc ccaccttcga ccgcaacccc
     2041 atcgagctcg ggaaggaggc caaggccgcg ggacgcgatc ccgccgagta cgtggtggac
     2101 cagctcggtt ccgggaaact gcggttcgcg gcggaggacc cggacgcgcc ggagaactgg
     2161 ccgcgggtgt tgacggtgtg gcgggcgaac ctgctgggat cctcggccaa gggcaacgag
     2221 tacttcctgc ggcacctgct gggcgcggat tcggcggtgc agggggccga ggcgggaccg
     2281 gggtcacggc cctcggaagt ggtgtggcgg gacgaggcgc cccagggcaa gttggacctg
     2341 ctggtctcgt tggacttccg gatgaccagc acgacgctgt tgtccgacgt cgtgctgccg
     2401 gcggcgacct ggtacgagaa gtacgacctg tcgaccacgg acatgcaccc gttcgtgcac
     2461 gcgttcgccc cggcgatcga cccgccctgg caggcgcgca ccgacttcga cgccttccac
     2521 gcgatcgcca agcggttcag cgagctggcg gagcggcatc tgggcgtggt gaccgatgtg
     2581 gtggcggtgc cgccccagca cgacaccccg ggcgagctgg cccaacccgg cggaaccgcc
     2641 cccgactgga aacgggacgg gcagatcccc gttcccggcc ggaccatgcc cgacctgatc
     2701 ccggtcgagc gcgactaccc ggccgtcgcg gagaagatgg cggccgtcgg cccattggcc
     2761 gagaccaagg ggctcccggt gaagggggtg tcgttcaccc ccgacaagga gatcgcctgg
     2821 ctggggcagc gcaacggcgt cgtcagcggt ggtgtcgccg atgggcgccc gctgctggac
     2881 accgacgtca aggtgtgcga aatgatcctg gcgttgtcgg ggacgagcaa cggccggctg
     2941 gcgtcgcagg ggttcgagcg gctggccgag cgcaccggga ccgacctgtc ggagttgatc
     3001 gagggcggac gggagcggag ggtggtgttc gccgacaccc ggacccggcc cacgccggtg
     3061 ggggccagtc cggagtggtc gggcaaggag gcggtggatc ggcgatacgc gccgttcacc
     3121 atcaacgtcg agcacgacaa gccgtggcac accctgaccg gacgccagca cttctacctg
     3181 gaccacgagt ggatgcgcga gttcggtggg gtcctgccgg tgtaccggcc gccgttggac
     3241 gcccaccggc tgttcgggga gccggagctg gggccgcggg ggcagcgcga ggtgacggtg
     3301 cgctacctga ccccgcattc gaagtggtcg atccattcgg agtaccagga caacctgttg
     3361 atgctgacgt tgtcacgggg cgggccgacg atctggatga gcccggccga cgccgaggtg
     3421 atcggggccc gtgacaacga ctgggtcgag gcggtcaacc gcaacggggt ggtcgcggcc
     3481 cgtctcgtgg tctcccaccg catgcccgcc ggaaccgtct acatgtacca cgcccaggaa
     3541 cggctggtcg cggtgccgaa gaccgagacg accggccggc gcggcggcat ccacaactcc
     3601 ctcacccgcc tcctcgtcaa accgacccat ctcatcggcg gctacgccca gttcgcctac
     3661 gggttcaact acatcggccc caccggcaac cagcgcgacg aagtgacggt cgtgcgtaag
     3721 cgggtcgccg aggtgaggta ctgacgccgg tccggagcag accagagcgg cggtcggaaa
     3781 gaggacacgg ggcgcgacgg tgacacgcgg tcggtgtgtc gccgatccac ggcacggccg
     3841 tgtggcggga tgccggccga ccacgaacga gctgacgagg tgaggagacg atggagattc
     3901 gcgatggcgc ggggcggccg atcgggcggg tgatggccca ggtcgcgatg gtgatgaatc
     3961 tggacaagtg catcgggtgc cacacgtgtt cggtgacgtg caagcaggcg tggaccaacc
     4021 gcagtggtgt ggagtacgtg tggttcaaca acgtggagac ccggcccggg cagggctatc
     4081 cgcgccagta cgaggaccag gagcggtggc ggggcgggtg gcggcgcacg ggatcgggcc
     4141 gactggtgcc cagagcgggg ggccggttgc acaagctggc cacgatcttc gccaatccgt
     4201 tgatgccgtc gattcaggac tactacgagc cgtggaccta cgactacgag aacctgatcg
     4261 tggcaccgtt gggcgatgac atgccggtgg cccggccgcg gtcgttgatc agcggcgagc
     4321 cgatgaacat cgagtggagc gccaactggg acgacaacct cggcggtggg ccggaggtgg
     4381 cgggcgggga cccgttggcg cggcggttgg gggagaaggt gcggttctcc ttcgaggagt
     4441 ccttcatgtt ctacctgccg cggatctgtg agcactgcct gaatccgtcg tgtgtggcct
     4501 cgtgtcccag tggggcgctg tacaagcgca gcgaggacgg catcgtccta gtcgatcagg
     4561 accggtgccg agggtggcgg atgtgcgtga cgggctgtcc gtacaagaag gtgtacttca
     4621 accacaagac cggcaaggcc gagaagtgca cgttgtgtta tccgcgggtg gaggtggggc
     4681 tgcccacggt ctgctcggag acgtgcgtgg gccggctgcg gtatttgggc gtggtgctct
     4741 atgacgccga gcgggtcgga caggccgcgg cggtggccga cgagcgggat ctgtacccgg
     4801 cgcagctgga cgtgatgttg gacccagagg acgagggggt gcgcgcggcg gcgcggcggg
     4861 acgggatcgc ggagcggtgg gtggagtcgg cgcggcgctc accggtgtac acgttggcgg
     4921 cgcggtaccg ggtggcgctg ccgttgcacc cggagtatcg gacgttgccg atggtgtggt
     4981 acgtgccgcc gttgtcaccg gtggtggacg cgctggtgga gaccggccac gacggggagg
     5041 cggccggaaa cctgttcggg gcgatcgagg cgttgcggat cccggtggag tacctggccg
     5101 agctgttcac ggcgggggac gtggagccgg tggtgggcgc gttgcggcgg ttggcggcga
     5161 tgcggtcgca catgcggcgg gtgaacctcg gggagccggt ggacgagggg atcgcggagg
     5221 cggtggggat gcggaccgcc gagatcgagg cgatgtaccg gctgttggcg gtggccaagt
     5281 acgacgagcg gtatgtgatt ccgacggcct acggggtgga cgaggcggat cgcggggtga
     5341 tcgaggaggt cgggtgcagc ctggacttcg agggaggccc aggaacgggg ggaatgggcg
     5401 gcgcggcgcc gtggggagaa gcgtcggggc gtgcgcgtcc ggcgacggtg gagaacttcc
     5461 acgcgctgcg tgtccgccaa tccggtgaga aaccgtcggg atcggcgaaa cgggtgaacc
     5521 tgctgaactg ggacggcagg ggccgccccg aaggactctt ccccaagaaa cgcaaggacg
     5581 gcgccgaagc ggccgaggag gggacggaat gagaagggtg agggccgcgc caagagggcc
     5641 gagaaggaac gggccatcgg gacggcgcgg gacacggcgg tcctgcgcca ggcggcgtcg
     5701 ctgctgctgg cctaccccga cgccgacttc cgcgagcggc tgccgctggt cgaacaggga
     5761 ctgcgggcgc tgcccgggag ccaggcgcgc gatgcgctgc tcggcctgtg ccgtcacacc
     5821 gccacggagt ccccgctgga tctggggatg cactacgtcg aggcgttcga catgcgcggg
     5881 aaacggaccc cgcacatgac cttctacctc gacggcgaca cccgccggcg ggggcacacg
     5941 ctcgcggcga tcaaggagat ctacaccgga tgcggctggg agctctcccc gcgtgagctg
     6001 cccgaccacc tcgccgtgat cctggagttc gccgcccgcg gcgacgccga atggggcgag
     6061 accctgttgc actacttccg gcccggactg gacctgctgg gcgccgccct gcacgagtac
     6121 gccaccccct acgcggccgt cctcgacgcg gtccgcgcca ccctgccgcc acccggcccc
     6181 gagcaggagg aggccgttcg caggctggcc cgcctcggcc cgcccgccga ggcggtcggt
     6241 ctcgacggct acggcgggcc cgtcgacctc ggcatgccgg gcgtcgggtc cccggtgaac
     6301 agcggaatcc tcgggggtgc gcgatgacct ggctggacta cgccctgtgg ggagtgctgc
     6361 cctacctggt gctcctcgtc ctggtcggcg ggaccgtgtg gcgttaccgc tacgaccggt
     6421 tcggttggac cacgcgctcc tcgcagctgt acgagtcgcg gctgctgcgg atcgccagcc
     6481 cgatgttcca cttcggcctg ctcgtcgtga tcgtcggcca cgtgatcggc ctgctcatcc
     6541 ccaagagctg gaccgaggcg gtcggcatcc ccgagtccgc ctaccacctc acggcgctgt
     6601 cgctgggcat cgtcgccggg gtgtgcaccc tgggcggcat cgcgctgctg atctggcggc
     6661 gccgcaccac cggaccggtg ttcagcgcca ccaccgtcaa cgacaagatc atgtacctgg
     6721 tgctgaccat ggccatcgtc gcggggctgg ccaccaccct gctgtcggcc ggggccgatc
     6781 tgaccggcgg ccacggccac gactaccgcg agaccgtgtc ggtgtggttc cgcagcatct
     6841 ggatcctgca acccgacgtg gcggccatgg cggcgtcgac cttcgccttc aaactccacg
     6901 tggtgatcgg cctggccctg ttcacgctcc tcccgttcac ccggctggtg cacgccttca
     6961 ccgcgccggt gggctacctc ttccggccct acgtcgtcta ccgggccagg gacccgcgtt
     7021 ccaccacccg gacctcccgt ccgatccgcc ggggctgggg gtgaggaagg ctcccgggcc
     7081 cctgacggga tgaacccgat gacggccctc accggcgcga gtgggctcgg gccggtgagg
     7141 ggcggtcgga caccgggcgc gccggggccc tcccctccgc gggcgggggc gtccatactc
     7201 tgaggggagc gatacgaggc gcgccggtcc gcggaggcga ccccgtggag ccgtccggcc
     7261 cctcgcctcg gtgcccaccc gcgtcggcgc cgggccgggg ctcacacccg gcgggagggg
     7321 gcgagatggg agacatcgac gcggtggtcg tggggaccgg tcccaacggt ctcgccgcgg
     7381 cggtgacgct cgcccgggcc ggactcaagg tcgagctgta cgaacggcac gacgtgatcg
     7441 gcgggggact gcgcaccgtc ccgctcttcg actccgacgt cgtgcacgac gtgtgcgccg
     7501 cggtccaccc gatggccgcg gcctcacgct tcttccggga gttcgacctg gtcgcgcgcg
     7561 gggtggacct gctccggccg gccgtctcct acgcccaccc cctgccccac gggcgcgcgg
     7621 cgctcgcggc ggccgacctg gacgccacct gcgccgggct gggcgaggac gcccggcgct
     7681 ggcgccgtct catggcgccg ctcgtcgcgc gcagcggggc cgtggtcgac ctcctcctct
     7741 cggacctgag gcgcctgccc gccgacccgg tcgccgccct ctccttcgcc cgccgcgtcc
     7801 tccaacacgg tcggggaacc ggccccttcg tcacggacgg cgccagggcc ctcctcgccg
     7861 gggtcgcggg gcacgtggtc ggtgccctgc cgtcgctgcc gggcgccgcc gtcgccctcc
     7921 tcctggggca cctggcgcac accgatgccg gatggcccct gccccgggga gggagcggag
     7981 tcatcgccga ggcgctcgcc gccgacatca ccgcgcacgg cggtgtcctg cgcaccggcc
     8041 acgagatcag ggacctcggc gacctgccgc cggcgcgctc ggtgctcctc gacgtcgccc
     8101 cgcgggggtt cctgcgcctc gcgggcgacc ggctccctcc ccgctaccgc agggcactgc
     8161 gccgcttccg ctacgccccg ggtgtggcca aggcggactt cctcgtcagc gagcccatcc
     8221 cctggacggc ccgggaggtc gccggggcgg gcaccgtgca cctgggcggc acgcaggagc
     8281 aggtcttccg cgtcgagacg gcgaccgcgc gcggccggcg gaccgacgag ccgttcgttc
     8341 tcctcgtcga tcccgcggtc accgacccga gccgggcctc ggggggcaga cgcccggtgt
     8401 gggcctacgc ccacgtgccc aacggggaca cccgggatcc ggtcgacatg atccgccggc
     8461 ggatcgagac ctacgccccc gggttcagcg acacgatcat cgcctcacga ggggtctccg
     8521 ccgcggagat ggaggcgtac aaccccaact acgtcggcgg ggacatcgcg tccggggcga
     8581 tgaccctgcg ccaggccctc atacggccca cgccgaggat cgatccctac cggacgccgt
     8641 tgccgggggt gtacctctgt tcggcctcgg tccctcccgg ccccggcgtg cacgcaatgt
     8701 cgggatacct cgccgcgctg tcggcgctcc gcaacgacca cggcgtgacc gtccccccgt
     8761 ccctgtcccc ctgaccgcct cgccggggcc gccgccgcgc cttggacggc cacgatggga
     8821 cgcgggtcag gagggaagcg cccaggtgag cagtgtgagc tgggcgatgg ccccggccag
     8881 gaacgcggcc acggccgcga cgcgccgagg cgccccggcc ccgcgccagc ggacgacgac
     8941 cgtcaccgcc cagccgacgc cgacggcgag gccggccgcc gtcgcgagcc gcaggaccca
     9001 taccgccgct ccgccggccg gcacccacgc gccgccggtg acgagggggg acagcgccat
     9061 catgggcgcg gcgaccgcca cacccaccgc gaggaggacc caggccaggc ccaggcggcg
     9121 ggacgcgcgg gccgccgtgc cacggcgtcc gcgcgcccgc gcgcgcacga cggcgcacac
     9181 ggcggcgacg gagagcacga gcacaccggc cagggcggtc acggtgaacc cccgacgggc
     9241 ccaccacggt gccggggcca gcgtctgttc gagcatcttg cggtcgccgc ggagcaggaa
     9301 caccgcgccg tcggccgaac ggacgcccgc gatgcagccg tgggggtcgc accagcgacc
     9361 gggcgccgcg ggggcgaacc gccgttcccc gaggagcaga tcctccccgt cccgggtgac
     9421 ggtcacctga cccgtcaggc tgcgcagcgc gagttcgggc ccgcggcccg cgaagagacg
     9481 ctcgtggaag gtgccgaccg ggaccgcggg ggcgaggtca ccggcccagg gcggcaccac
     9541 cgtggggcgt cccgcctgcg gctccggggc cgccgcgacc cggccggtgg ccaccgccca
     9601 cctggcgacg gcgtccacga cggcgggggc gaagggcatg gcgtccgcgg tgtcggaggt
     9661 gacggccgcg aagacgccga gtccggcctc gggcagcagg gcgagccagg cgacgccgtt
     9721 cccaccggcg tgctcgagta cgcggacccc ctcccgccac gtctcgaaga agacctgggt
     9781 gtggccgtca ccaccgtgcg ccgggcggac ggcggtggtc gtggcctcgg cgacgacctc
     9841 gggggagagc cgcccgttgt cggcgaggag ggcgtgcagc aatgcggcgg cgtcgcgggt
     9901 ggaccaggtc agtgacgcgg agggggcctc gtgcacggcc ggccagggcg aggcggtcca
     9961 accggtgtcg tcgggcgcgg tcagcacgac gtcgccgtcg gccggttccg tcgcgccgaa
    10021 tccggcgtct cgggcgccca ccggctccag cacgtgttcc ctcgcggcct ggtcgaaggg
    10081 ccggcccgtg gcctgctcga tggcggcgcc gatcagggtg tagccctgga ggggggagta
    10141 gtggagcccg acgtcggcgg ggtggcgcag ggtcggggga tgctcgtcca gccacgatcg
    10201 cagggagcgc gcgacctggt tcgcgtcgtc gggcggatcg gggtggagga gcaggggctc
    10261 ctccaggccg gagtggtggg tgagcaggtg tctcccggtc accggggtgc gcgcggccgg
    10321 ggcgcggcgg tcgcgaagcg tgacccctgc gagggagccg atctcggcgt cgaggtcgag
    10381 ggaaccttga tggtgcaggg acaacgcggt cagcgcggtc acgaccttgg acacggacgc
    10441 gaccggtgtg cgcgagtcga ccgtcagcgg gacgccgcgc atgggatcgg cctggccccg
    10501 cgcgtcgagc accagcgggc cgtccgcgtc gacgacggcg atcatcgccc cgggggtggt
    10561 gtgtcccacg tgtccgcgcg ccaggtcgtc gatcagttcc tccagggcgg cgcggtcctc
    10621 cggtcccgtc gtcgccggcg ggtgcgcgtg gcctccccct tgcgcggtgg cggcgttcgc
    10681 gtcgccggcc gctccaccga gcacgcttcc gcagacgagc gcgacgcaca ggacgccgag
    10741 cgccacgtca cgtgttcgag gcacggctcc ccctgctatg taatacgggc gtgttggaaa
    10801 gaagctaaca cagctgtact actaaacggt atggaggact catgccgcac agggtcgacc
    10861 acgacgcccg aaggagccgg ctcgtcgagg cggcgatgcg cgtcgtcgca acggacggct
    10921 tcgccgcggt ctccgtgcgc cgggtcgcgg ccgaggccgg ccactctccc ggctcgctca
    10981 gatacttctt ccccacccag gagtcgctca tcgaagccgc gctcgcccac gtcaccgaac
    11041 tcgcggccga gcgactggtc gggcggatcg tcgcgttcga gaacgccgac gccggccgcg
    11101 tggtcgacgc ggcgtgcgcg ctgatcgagg agctgctccc cctcgacgag acgcgccgcg
    11161 ccgagtggcg catctacgga gcgctcagcg agccctctgt cgcgacgagc gcactcgccc
    11221 gttggcggaa ggcgggctgg gccggcacgc gccaccagtg ccggcgcgtc gtgcgcggcc
    11281 tcaccggggg cggcgtcaac ggcgccgccg cgcgcgtagc cgacccgccg ccggacgccg
    11341 aggcgatcct ggccgcagcc gagcgactcg cggcgtcgcc ggacgacacc gtcgagcagc
    11401 gcgccgccgg actgcacgcc ctcatcgacg ggctcggagc gcaactcgtc cagttccccg
    11461 acatggtcac ggagcgggcc gcgcgggcga cggtgcgccg ggccgtcacc gacctcgccc
    11521 gggtcctctc cccggacctc tagggggtgt gccgtccacc ggcgtgctcg ccccgcggac
    11581 cggtcccgcg acgctcccgg cgtcgccgtc ctcgtgaggg gaaccggcgg aggtccgccc
    11641 cgcttgacgc gcacgggctg acttggacgt ccagggagga gcgccatcga agccgtggaa
    11701 gggccgtcgg cggacctcgc cgccgttccc ggacgtctcg ttttccctat tcaggcgggg
    11761 tatctgagga gtcggggcgg tcgtggcgac atccgccccg ggaagcctcc atcgaccgat
    11821 gtgacgcttt gtgttcacgt gcgcgcgcgg cgtggtaaga attcgctggg cacatcgggg
    11881 aggaggtgac gggtgggata cgcgcgacgg gtcatggacg ggatcggcga ggtggccgtg
    11941 accggggccg gcggctccgt caccggggca cggctgcggc atcaggtccg cctgctggcc
    12001 cacgccctca ccgaggccgg gatccctccg ggacgcgggg tggcctgcct ccacgcgaac
    12061 acctggcggg cgatagcgct gaggctggcg gtccaggcca tcggctgtca ctacgtgggc
    12121 ctgcgtccga cggcggccgt caccgaacag gccagggcga tcgccgcggc ggacagcgcc
    12181 gccctcgtgt tcgagccctc ggtcgaggcg agggccgccg acctgctgga acgtgtgtcg
    12241 gtgcccgtgg tcctctccct ggggccgacc tcacgcgggc gagacatcct ggcggcctcc
    12301 gtccccgagg ggacaccgct ccgttaccgg gagcaccccg aggggatcgc cgtggtggcg
    12361 ttcaccagcg gcaccaccgg gacgcccaag ggggtcgccc acagcagcac ggccatgtcc
    12421 gcctgcgtgg acgccgccgt ctccatgtac ggcagggggc cgtggcgttt cctgatcccc
    12481 atcccgctgt cggacctggg cggtgaactc gcgcagtgca cgctcgccac cggcggcacc
    12541 gtggtgctgc tggaggaatt ccagcccgac gccgtcctgg aggcgatcga gcgtgaacgg
    12601 gccacccatg tcttcctcgc gccgaactgg ctctaccagc tcgccgaaca cccggcgctg
    12661 ccgcgcagcg acctgtccag cctccgcagg gtcgtctacg gtggggcgcc ggccgtcccc
    12721 tcgcgtgtcg cggcggcccg cgagcggatg ggcgcggtcc tgatgcagaa ctacggcacg
    12781 caggaggccg ccttcatcgc ggcgctcaca ccggacgacc acgcgcgccg cgagctgttg
    12841 acggcggtgg gccggcccct gccgcacgtc gaggtcgaga tccgcgacga cagcgggggc
    12901 acgttgccac ggggcgcggt cggcgaggtc tgggtgcggt cccccatgac gatgagcggg
    12961 tactggcgcg accccgaacg caccgcgcag gtactgagcg gcggctggct gcgcaccgga
    13021 gacgtcggga cgttcgacga agacggccat ctccacctga ccgaccgcct ccaggacatc
    13081 atcatcgtcg aggcctacaa cgtctactca cgccgggtcg agcacgtgct caccgagcac
    13141 cccgacgttc gcgccgcggc cgtcgtcggg gtccccgatc ccgacagcgg ggaggccgtc
    13201 tgcgcggccg tggtggtcgc cgatggcgcc gaccccgatc ccgaacacct gcgcgccctg
    13261 gtccgcgacc acctcggaga cctccatgtc ccccgacggg tggaattcgt gcggagcatc
    13321 cccgtcaccc cggcgggcaa gccggacaag gtcaaggtac gaacctggtt caccgactga
    13381 gcggcccgag aagtcccgcg ggcgacgtcc gcccccgccc caaccgacgc acgccttcat
    13441 ccgacgagca taaggagaca acggtgaggc agatcgaaat cgaatgggtc cagccgggca
    13501 tcacggtcac ggccgacctg agctgggaac gcaacccgga gctggccgaa ctgctgtgga
    13561 cggggcttct cccctacaac agcctgcaaa accacgccct ggtctccggc aaccacctct
    13621 accacctcat cgccgacccc cggctcgtct acaccgaggc ccgttataag gaggaccgca
    13681 cgaagtcccc cgacggcacg gtcttcctgt cccaactcca gcacctggcg gtcaagtacg
    13741 ggccgctgac cgagtacctg ccggccgcgc ccgtcggctc ggtcgtcccc gaggacatcg
    13801 acgccctgcg cgaggccggc cgggcgtgct ggaaggccgc gtgggagacc aagcagccca
    13861 tcgaggtcag ggtgcgccgc aagggcgagg cggtgaccga cttcgcgctg ccgcgcacgc
    13921 cgcccgtcga ccatcccggc gtgcagaaac tggtcgagga gatccaggac gagaccgagc
    13981 gggtgtggat caccccgccc gccgagatcg tggacatgca ccagggacgg atcgcgagcc
    14041 gggccggaag ctacgaccag tacttctcca ccctggtgtt cctcaacgga gaggtgcggc
    14101 cgctcggcta ctgcgccctg aacgggctcc tcaagatctg ccggaccacc gacctcaccc
    14161 tgaacgacct gaagcggatc acccccacct tcatcaagac cccggcggag ttcctggggt
    14221 acacgggcct ggacacgttg tggaggttca cccagcaggt gctgacgctc ctgcccgacg
    14281 tggagacccg ggaacagtac ttcgccctgg tcaacgccct cgccctgtac gcgaacatgc
    14341 tcaacacctg gaacctccac ttcttcccgt ggcagcacgg caccgactac cgctatctgg
    14401 acgcatgacc gacagggaac cggtggggcc ggccgggccg tacgcggcgg tgctggagga
    14461 catgcggcgc aggatgttgc gtcccgacga gcagaaccgc gacgaactgc gcgagcggat
    14521 cggcgtcctg ttctccggcc tcccccgcga cacgccggcc gacgactcct ggctcggtac
    14581 ggcgaccccg gactacggct ggttacgggc gttcgagcac ataccgcgga ccggcgcgga
    14641 tcgcgatctg gtgctcggcg cggtcgcggc ggccctcaac gggcagttgc gccagcactc
    14701 gctgggcacc ttcttcaacc tgatgccgct gccgctgctc gacgcggtgg cggcggcggc
    14761 cgtgaccgat ctctacagcc ccaacgccct gtgggacctg gtcagttccg gtgtgctcga
    14821 cgtcgaacgg cagatcgtcc ggcagctcgc cgggctggcc ggctggcggc ccgagctggc
    14881 cgggggcacg ttctccttcg ggggcaaggc cgggctgatc tacgcgatcc gcctggggct
    14941 gaaccgctgc cggccggagg catcacggcg ggggctggcc gggggaccgg ccccggtggt
    15001 gatcaccacc ggccacaacc acgacagcgt ggagatggcc tgctcgctcc ttgggctggg
    15061 gaccgaggcg tgcctgcgcg tccccgtggc cccggggcgg gcggtgtcgc cccgggcggt
    15121 cgaggagacg gtcgccgggc tggtggcgcg gggggttccg atcgcctgcg tggtgctgtc
    15181 gggcggcaac atcctgcaca acgcgatgga cccggtccac gaggtcgccg acgcgctgac
    15241 ccggacctgt cgagggctgt cctaccggcc ctatctccac ttcgacaccg cgttcggctg
    15301 gccgtggctg ttcttcgggg actacgactt cgccggcaac cccctcggta tcgaggaggg
    15361 cgtgctggcc cgcatcgaac agtccacgcg cctggtcacc ggggtcgagg ccgccgactc
    15421 gatgaccgcg gacttccaca agatcggttt ctgcccctac tcctccagcg tcttcctcgc
    15481 caaggaggac gccgagctgc gatcgctcca cggcgaaacg acgaccccgc gcgagggggc
    15541 gtggggggac accctcgtgc tccaccacac catcgaacac tcccgcagcg gggcggggat
    15601 cctcgccgcc tgggtggccc tgcaaagcgt cggccggacc ggtttccagg tctatctcgc
    15661 ccacatgatc gccatctccg acgtcttccg gtccctcctg ccgggcgggg ggtatgagct
    15721 gctcaacccg tgggcgaccg gtcccacggc cgtgtactgg cccgtgccgc caggggggcc
    15781 ggaccgcttc gccgacctgc gcggcggcga ctcgtcgccg ctcatcgagc gcgcgaaccg
    15841 ctacacccac gccctgtacc ggcggctggc cggcctcgac gggaaggccg gcgcgagcag
    15901 gatcacgttg gggctcctcc ccacctacga gcggagcgcc cgaggagaac cgatcgcggc
    15961 actgcggctg cttcccacct cgctccacca cgaccattcc cgcaccgcgg aactggccgg
    16021 acgcatggtc gaggtgaaga aggaactcga caagacggtc gagcgcggtt cggggtggct
    16081 tcccgacgcc cgtctctatc cggttccgga gtgaacctgc ggcgcggggc gggtccgggc
    16141 cggacacgag gggtttccgc cagtgtcgga cgtaccgggc cggcggcgac ctcgcgaaca
    16201 cccaaggcgt gtacggggaa cccgtgaagc gccgcgggtg gccgagcgcg ggttccgccc
    16261 gccctcggcc ggcgcgtacc cgtctcgttc ccgcaggcgg ttcgaatcgg atgcggtgat
    16321 agatcaatgg gtcctttccc atggggagcg gcctggacgt tcaggtctgg gcgaacatgg
    16381 cggcgtggtc gcgggcgaag tcggtgatgt cgcgcgcggg ccttccggtg aggtcggtga
    16441 cgcaggagta cacctccgcg gcttcaccgc gggcgtagtg ggcgtagtcc tcgacgaggc
    16501 cgtcgagctg ccatggcggc atgagcccgg tcagcgcggc ggcgaactgt tcgtcgggca
    16561 cctcctggaa ggtgatctcc cgcccggtgg cggtggagag cgcctgggcg atctggccgt
    16621 gggtcacggc gcggggcccg gtcaacgtgt aggtgcggcc ggtgtgcccc gacgtggtca
    16681 gcacgaccgc ggcggtctcc gcgatgtccc tggtgtcgat gacgctgacg gcggcgtcgc
    16741 cgatgggcgc ggcgaaccag ccctgtgcga tggtgccggc gaaaccgagc agtgcctgca
    16801 tgtagaggtt ggggcgcagc acggtgtggt cgaggccgag tcgccgcacg tgcgcctcga
    16861 cttcggcgtg ccagcgcagg aaccgcaccg gcgagtcgac gcgcgccgcg tactgcgaga
    16921 gcagcacgag ccggctgacg ccggcgtcgc gggccaggtc ggcgaaccgg atctgtagcg
    16981 ccgcggcgtc ctgcgccgag gggctgttga ggaagaccgc gtcgacgccc tgcacagcgg
    17041 tggcgaccgc ccgcgggtcg ttcaggtcgg cgacgacgtt ctcgacgccg gggacggcgc
    17101 ggccggcgtc gcggaccatg gcgcggacgg tggcgccgcg ggcgcgtagg gcggggacca
    17161 gggcggatcc cacggttccg gtcgctccgg tcacgagtac ggtgggcgtg ttcatcggtg
    17221 tgtcctttcc tggtggtgtc atcggggtct gttgctcgaa ggggttatcg aagggcagga
    17281 ggggccggcg gcggccgggg gcattcgggg gtgggacaga gggagaaggg ccaggacgag
    17341 ggagacgacg acgagcacgc tctggccgag gaggacggtc gtgaacgcga tgccgcctga
    17401 tgtccccgcg gtgccgatgg cgatcccggc cagggcggcg agcccgatcg cgccgcccag
    17461 ccgctgcacg gcgttgacca gcccgctgag cacacccgat tcgccttccc cggtgtcgtg
    17521 cagcgccatc gaggtggcgg tgacggcgcc gaggcggccg ccgagcagca atccggcgaa
    17581 cgcgatgagg tagccgttca cgacgagtgt gagttcagcg gtcgagagcc cgaggtcctc
    17641 gcggatcgcc ggctcggcga ggtcgatcat cgcggtggtg agaacgatca ggaacatgga
    17701 ggtcgccagc ccggccaccg cgcgtggtac tcgcgggcgt gggcgggtgt ccgccgtggg
    17761 gggcgtggtt ggggcgctca tcggtccgtc cttccagcga gtgttcgctt ccacggttgg
    17821 ggcggtggtg acgcgctccc gtctcgatgt gcccggtcgg tcgcaattct ctctttgaga
    17881 gtgagtagtc actatcaaaa acttaaaaaa cacgttgctt ccggcgctca ggagccggaa
    17941 tccagaaaac gcttggccca ctcgtcgtgt tcggcgcggg ccggcaggtc catggaggcg
    18001 gccaccatgt acaacatgcc cgcggcgaag aagtcgtgcg ccggatcggt gccgacctcg
    18061 ggcaggacct ccaagcgctc gaagacgtcc tgtgtccatc ggtgcatcag gtcgcgaatg
    18121 tcgggatcct cgcaggcggc atacccctgg agcaggatga gcatcagctc gcgtcgttcc
    18181 atcaggcttc cccaggcgtc cgccatcgtc tggagtggat cgcgttcggc ggcctcgccc
    18241 ggaacgagca tctcctgtgc gatcgtttcg aaggtctgct ccaggaccgc gatgaacagc
    18301 tccttcttgg tcgagaagac acggaacagg ttcgggtggg agatctcgac cgccttggcg
    18361 atgttcacgg tcgaaccacc gtggagcccc ttgtgactga actccttcag cgccgcggcg
    18421 aggatctgct cgcggcggcg ttcgaagctg acccgtggtc tgcgccctcc cggcat
//
