BGC0001137: marinacarboline A biosynthetic gene cluster from Marinactinospora thermotolerans
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Location: 1 - 18,476 nt. (total: 18,476 nt).
This entry is originally from NCBI GenBank KC541560.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001137
Short description marinacarboline A biosynthetic gene cluster from Marinactinospora thermotolerans
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Remarks "Paper for this gene cluster:\nChen Q, Ji C, Song Y, Huang H, Ma J, Tian X, Ju J.Discovery of McbB, an enzyme catalyzing the beta-carboline skeleton construction in the marinacarboline biosynthetic pathway.Angew Chem Int Ed Engl. 2013,52(38):9980-9984. \n"
Biosynthetic class(es)
  • other (other)
Loci
KC541560.1
via Knock-out studies
Compounds
  • marinacarboline A
  • marinacarboline B
  • marinacarboline C
  • marinacarboline D
Species Marinactinospora thermotolerans [taxonomy]
References
Chemical products information
marinacarboline A Evidence:
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C23H21N3O3
Chemical database entries
NPAtlas
marinacarboline B Evidence:
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C22H19N3O3
Chemical database entries
NPAtlas
marinacarboline C Evidence:
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C22H19N3O2
Chemical database entries
NPAtlas
marinacarboline D Evidence:
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C24H20N4O2
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AGL76713.1
 1 - 3744 (+) nitrate reductase subunit alpha
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    • AGL76714.1
    		 3891 - 5612 (+) nitrate reductase subunit beta
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      • AGL76715.1
      		 5848 - 6327 (+) nitrate reductase delta subunit
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        • AGL76716.1
        		 6324 - 7064 (+) respiratory nitrate reductase subunit gamma
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          • AGL76717.1
          		 7245 - 8774 (+) FAD dependent oxidoreductase
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            • AGL76718.1
            		 8827 - 10764 (-) beta-lactamase
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              • AGL76719.1
              		 10842 - 11543 (+) TetR family transcriptional regulator
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                • AGL76720.1
                		 11893 - 13380 (+) fatty acid CoA ligase
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                  • AGL76721.1
                  		 13464 - 14408 (+) cucumopine synthase
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                    • AGL76722.1
                    		 14462 - 16114 (+) glutamate decarboxylase
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                      • AGL76723.1
                      		 16361 - 17242 (-) NAD(P)H azoreductase
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                        • AGL76724.1
                        		 17239 - 17892 (-) putative drug resistance transporter
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                          • AGL76725.1
                          		 17928 - 18476 (-) TetR family transcriptional regulator
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                            Biosynthesis information
                            Annotation changelog

                            Entry version: 4

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2022-10-07
                            Update chemical activity to schema version 2.11
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                            Entry version: 3

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2022-09-15
                            Updated bioactivity data
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                            Entry version: 2

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2019-10-16
                            Migrated from v1.4
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            2019-10-16
                            Updated compound(s) information (NPAtlas curation)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                            Entry version: 1

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2015-06-12
                            Submitted
                            • (ID: AADADFAEMFE2AOMR24EUYNFH)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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