Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001137.1:
Cluster 1Alkaloid118476

BGC0001137, marinacarboline biosynthetic gene cluster from Marinactinospora thermotolerans. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: marinacarboline a
SMILES string: Copy to clipboard
Molecular formula: C23H21N3O3
Exact molecular mass: 387.1583 Da ([M-H]-)
Molecular activity: Other
Molecular target: unknown

Class-specific details

Biosynthetic class(es):
Alkaloid
Alkaloid subclass:
Indole/benzopyrrole

Gene cluster description

marinacarboline (BGC0001137). Gene Cluster 1. Biosynthetic class = Alkaloid. GenBank KC541560, positions 11893-16114. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies
MIxS-compliance:Unknown
Comments:Paper for this gene cluster: Chen Q, Ji C, Song Y, Huang H, Ma J, Tian X, Ju J.Discovery of McbB, an enzyme catalyzing the beta-carboline skeleton construction in the marinacarboline biosynthetic pathway.Angew Chem Int Ed Engl. 2013,52(38):9980-9984.
Contact for this cluster:Jianhua Ju (South China Sea Institute of Oceanology, Chinese Academy of Sciences)

Literature references

1. Chen Q et al. (2013) Discovery of McbB, an enzyme catalyzing the beta-carboline skeleton construction in the marinacarboline biosynthetic pathway. Angew Chem Int Ed Engl 52(38):9980-4. doi: 10.1002/anie.201303449.