BGC0001137: marinacarboline A biosynthetic gene cluster from Marinactinospora thermotolerans
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Location: 1 - 18,476 nt. (total: 18,476 nt).
This entry is originally from NCBI GenBank KC541560.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
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KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001137
Short description marinacarboline A biosynthetic gene cluster from Marinactinospora thermotolerans
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Remarks "Paper for this gene cluster:\nChen Q, Ji C, Song Y, Huang H, Ma J, Tian X, Ju J.Discovery of McbB, an enzyme catalyzing the beta-carboline skeleton construction in the marinacarboline biosynthetic pathway.Angew Chem Int Ed Engl. 2013,52(38):9980-9984. \n"
Biosynthetic class(es)
  • Alkaloid (Indole/benzopyrrole)
Loci NCBI GenBank: KC541560.1
Compounds
  • marinacarboline A
  • marinacarboline B
  • marinacarboline C
  • marinacarboline D
Species Marinactinospora thermotolerans [taxonomy]
References
Chemical products information
marinacarboline A
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C23H21N3O3
Chemical database entries
NPAtlas
marinacarboline B
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C22H19N3O3
Chemical database entries
NPAtlas
marinacarboline C
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C22H19N3O2
Chemical database entries
NPAtlas
marinacarboline D
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C24H20N4O2
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AGL76713.1
 1 - 3744 (+) nitrate reductase subunit alpha
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  • AGL76714.1
 3891 - 5612 (+) nitrate reductase subunit beta
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  • AGL76715.1
 5848 - 6327 (+) nitrate reductase delta subunit
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  • AGL76716.1
 6324 - 7064 (+) respiratory nitrate reductase subunit gamma
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  • AGL76717.1
 7245 - 8774 (+) FAD dependent oxidoreductase
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  • AGL76718.1
 8827 - 10764 (-) beta-lactamase
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  • AGL76719.1
 10842 - 11543 (+) TetR family transcriptional regulator
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  • AGL76720.1
 11893 - 13380 (+) fatty acid CoA ligase
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  • AGL76721.1
 13464 - 14408 (+) cucumopine synthase
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  • AGL76722.1
 14462 - 16114 (+) glutamate decarboxylase
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  • AGL76723.1
 16361 - 17242 (-) NAD(P)H azoreductase
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  • AGL76724.1
 17239 - 17892 (-) putative drug resistance transporter
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  • AGL76725.1
 17928 - 18476 (-) TetR family transcriptional regulator
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Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AADADFAEMFE2AOMR24EUYNFH, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Similar known gene clusters
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