Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001138.1:
Cluster 1Other139199

BGC0001138, A201A biosynthetic gene cluster from Marinactinospora thermotolerans. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: a201a
SMILES string: Copy to clipboard
Molecular formula: C37H50N6O14
Exact molecular mass: 802.3385 Da (None)
Molecular activity: Antibacterial
Molecular target: binds to ribosome so as to inhibit protein synthesis

Class-specific details

Biosynthetic class(es):
Other biosynthetic class:

Gene cluster description

A201A (BGC0001138). Gene Cluster 1. Biosynthetic class = Other. GenBank JN651966, positions 3630-37225. Click on genes for more information.


biosynthetic genes
transport-related genes
regulatory genes
other genes

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies
Contact for this cluster:Jianhua Ju (South China Sea Institute of Oceanology,Chinese Academy of Sciences)

Literature references

1. Zhu Q et al. (2012) Discovery and engineered overproduction of antimicrobial nucleoside antibiotic A201A from the deep-sea marine actinomycete Marinactinospora thermotolerans SCSIO 00652. Antimicrob Agents Chemother 56(1):110-4. doi: 10.1128/AAC.05278-11.