BGC0001140: platensimycin biosynthetic gene cluster from Streptomyces platensis
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Location: 4,531 - 45,738 nt. (total: 41,208 nt).
This entry is originally from NCBI GenBank FJ655920.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001140
Short description platensimycin biosynthetic gene cluster from Streptomyces platensis
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • terpene (Diterpene)
Loci
FJ655920.1
4531 - 45738
via Knock-out studies, Heterologous expression
Compounds
  • platensimycin
  • platencin
  • thioplatensimycin
  • thioplatencin
  • platensilin
  • thioplatensilin
Species Streptomyces platensis [taxonomy]
References
Chemical products information
platensimycin Evidence: NMR [1], Mass spectrometry [1]
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C24H27N1O7
Chemical database entries
PubCHEM
NPAtlas
platencin Evidence: NMR [2], Mass spectrometry [2]
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C24H27N1O6
Chemical database entries
PubCHEM
NPAtlas
thioplatensimycin Evidence: NMR [8], Mass spectrometry [8]
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C24H27N1O6S1
Chemical database entries
PubCHEM
NPAtlas
thioplatencin Evidence: NMR [8], Mass spectrometry [8]
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C24H27N1O5S1
Chemical database entries
NPAtlas
PubCHEM
platensilin Evidence: NMR [9], Mass spectrometry [9]
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C24H27N1O6
thioplatensilin Evidence: NMR [9], Mass spectrometry [9]
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C24H27N1O5S1
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ACO31265.1
 4628 - 5392 (-) ketoreductase
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    • ACO31266.1
    		 5389 - 5943 (-) PtmU1
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      • ACO31267.1
      		 6030 - 7334 (+) CoA ligase
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        • ACO31268.1
        		 7331 - 8041 (+) PtmU2
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          • ACO31269.1
          		 8087 - 8488 (-) PtmR2
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            • ACO31270.1
            		 8488 - 9645 (-) PtmD
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              • ACO31271.1
              		 9647 - 11215 (-) CoA ligase
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                • ACO31272.1
                		 11244 - 12326 (-) nonheme diiron monooxygenase
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                  • ACO31273.1
                  		 12408 - 13262 (-) PtmH
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                    • ACO31274.1
                    		 13327 - 14253 (-) ent-atiserene synthase
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                      • ACO31275.1
                      		 14250 - 15572 (-) PtmO2
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                        • ACO31276.1
                        		 15572 - 17173 (-) ent-copalyl diphosphate synthase
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                          • ACO31277.1
                          		 17311 - 18168 (+) hydroxylase
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                            • ACO31278.1
                            		 18168 - 19334 (+) dehydrogenase
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                              • ACO31279.1
                              		 19331 - 20260 (+) PtmT3
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                                • ACO31280.1
                                		 20301 - 21593 (+) PtmO5
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                                  • ACO31281.1
                                  		 21590 - 22657 (+) PtmR3
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                                    • ACO31282.1
                                    		 22745 - 23587 (+) PtmO6
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                                      • ACO31283.1
                                      		 23644 - 24690 (+) PtmT4
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                                        • ACO31284.1
                                        		 24690 - 26036 (+) PtmM1
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                                          • ACO31285.1
                                          		 26044 - 27144 (+) PtmM2
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                                            • ACO31286.1
                                            		 27131 - 28894 (+) PtmM3
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                                              • ACO31287.1
                                              		 28972 - 29805 (+) ADHOHP synthase
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                                                • ACO31288.1
                                                		 29857 - 30963 (+) ADHOHP synthase
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                                                  • ACO31289.1
                                                  		 30969 - 32159 (+) PtmB3
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                                                    • ACO31290.1
                                                    		 32218 - 33093 (+) PtmC
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                                                      • ACO31291.1
                                                      		 33179 - 34603 (-) PtmP1
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                                                        • ACO31292.1
                                                        		 34675 - 35919 (+) PtmP2
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                                                          • ACO31293.1
                                                          		 35934 - 36839 (+) PtmO7
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                                                            • ACO31294.1
                                                            		 36872 - 37588 (-) PtmR1
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                                                              • ACO31295.1
                                                              		 37880 - 38716 (+) PtmO8
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                                                                • ACO31296.1
                                                                		 38713 - 40503 (+) PtmU4
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                                                                  • ACO31297.1
                                                                  		 40542 - 42125 (+) PtmA3
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                                                                    • ACS13710.1
                                                                    		 42293 - 43507 (+) PtmP3
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                                                                      • ACS13711.1
                                                                      		 43625 - 45247 (+) PtmP4
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                                                                        • ACS13712.1
                                                                        		 45271 - 45606 (+) PtmO9
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                                                                          Biosynthesis information
                                                                          Annotation changelog

                                                                          Entry version: next

                                                                          Date
                                                                          Changes
                                                                          Submitters
                                                                          Reviewers
                                                                          2024-03-19
                                                                          MIBiG v4 annotathon
                                                                          • (ID: Z4WHVO6K4QR4NSPFS3BTTXEO)
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                          Entry version: 4

                                                                          Date
                                                                          Changes
                                                                          Submitters
                                                                          Reviewers
                                                                          2022-10-07
                                                                          Update chemical activity to schema version 2.11
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                          Entry version: 3

                                                                          Date
                                                                          Changes
                                                                          Submitters
                                                                          Reviewers
                                                                          2022-09-15
                                                                          Merged annotations from duplicate entry BGC0001898
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                          2022-09-15
                                                                          Fixed gene accessions
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                          Entry version: 2

                                                                          Date
                                                                          Changes
                                                                          Submitters
                                                                          Reviewers
                                                                          2019-10-16
                                                                          Migrated from v1.4
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                          2019-10-16
                                                                          Updated compound(s) information (NPAtlas curation)
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                          Entry version: 1

                                                                          Date
                                                                          Changes
                                                                          Submitters
                                                                          Reviewers
                                                                          2015-06-12
                                                                          Submitted
                                                                          • (ID: QARZXBIU2LN42R2C3IX7JEGD)
                                                                          • (ID: E2T2HCM4X7QXVS4LL4JVBPPK)
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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