Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001140.1:
Cluster 1Terpene141208

BGC0001140, platensimycin / platencin biosynthetic gene cluster from Streptomyces platensis. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: platensimycin
PubChem ID: 6857724
SMILES string: Copy to clipboard
Molecular formula: C24H27NO7
Average molecular mass: 441.48 Da
Molecular activity: Antibacterial, Inhibitor
Molecular target: FabF fatty acid synthase

Class-specific details

Biosynthetic class(es):
Terpene
Terpene subclass:
Other
Terpene subclass by size:
Diterpene
Final isoprenoid precursor:
GGPP
Terpene synthase/cyclase-encoding genes:
ACO31274.1, ACO31276.1, ACO31279.1
Prenyltransferase-encoding genes:
ACO31283

Gene cluster description

platensimycin / platencin (BGC0001140). Gene Cluster 1. Biosynthetic class = Terpene. GenBank FJ655920, positions 4628-45606. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies, Heterologous expression
MIxS-compliance:Unknown
Contact for this cluster:Xiaohui Yan / Michael Smanski (The Scripps Research Institute / University of Minnesota)

Literature references

1. Smanski MJ et al. (2009) Engineered Streptomyces platensis strains that overproduce antibiotics platensimycin and platencin. Antimicrob Agents Chemother 53(4):1299-304. doi: 10.1128/AAC.01358-08.
2. Yu Z et al. (2010) Engineering of Streptomyces platensis MA7339 for overproduction of platencin and congeners. Org Lett 12(8):1744-7. doi: 10.1021/ol100342m.
3. Smanski MJ et al. (2011) Dedicated ent-kaurene and ent-atiserene synthases for platensimycin and platencin biosynthesis. Proc Natl Acad Sci U S A 108(33):13498-503. doi:
4. Smanski MJ et al. (2012) Expression of the platencin biosynthetic gene cluster in heterologous hosts yielding new platencin congeners. J Nat Prod 75(12):2158-67. doi: 10.1021/np3005985. Epub 2012 Nov 16.
5. Yu Z et al. (2013) Isolation and structural elucidation of glucoside congeners of platencin from Streptomyces platensis SB12600. J Antibiot (Tokyo) 66(5):291-4. doi: 10.1038/ja.2013.1. Epub 2013 Jan