BGC0001141: 4-epi-15-epi-brefeldin A biosynthetic gene cluster from Penicillium brefeldianum
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Location: 1 - 37,663 nt. (total: 37,663 nt).
This entry is originally from NCBI GenBank KJ728786.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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Gene details
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General
Compounds
Genes
Polyketide
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001141
Short description 4-epi-15-epi-brefeldin A biosynthetic gene cluster from Penicillium brefeldianum
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide (Other)
Loci NCBI GenBank: KJ728786.1
Compounds
  • 4-epi-15-epi-brefeldin A
Species Penicillium brefeldianum [taxonomy]
References
Chemical products information
4-epi-15-epi-brefeldin A
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C16H24O4
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AIA58894.1
 263 - 2905 (+) putative F-box domain protein
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  • AIA58903.1
 3699 - 4681 (-) thiohydrolase
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  • AIA58895.1
 5541 - 7257 (+) putative cytochrome P450
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  • AIA58896.1
 7855 - 9494 (+) putative cytochrome P450
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  • AIA58897.1
 10514 - 12193 (+) putative cytochrome P450
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  • AIA58898.1
 12965 - 14473 (-) putative cytochrome P450
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  • AIA58899.1
 16191 - 23507 (+) HRPKS
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  • AIA58900.1
 24185 - 25201 (-) putative large tegument protein UL36
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  • AIA58901.1
 29688 - 34538 (-) putative WD-40 protein
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  • AIA58902.1
 36036 - 37660 (+) putative kinesin
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Polyketide-specific information
Subclass Other
Starter unit Acetyl-CoA
Cyclic? yes
Release type
  • Macrolactonization
Polyketide-synthases
Genes Properties Modules
AIA58903.1
+
AIA58899.1 		Synthase subclass: Iterative type I
Thioesterases:
  • AIA58903.1 (Unknown)
Iterative PKS type: Highly reducing, Unknown
Iteration counts: 7
Module 1
Specificity: Malonyl-CoA
Evidence for specificity: Activity assay
Genes: AIA58899.1
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Enoylreductase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: BMUFDHMMOLZWQLUNJMQED2GP, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Corrected gene identifiers
Detailed domain annotation
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