BGC0001141 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001141 (Penicillium brefeldianum)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	37,663	4-epi-15-epi-brefeldin A	PKS:Iterative type I	100%

BGC0001141 - Region 1 - T1PKS

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Location: 1 - 37,663 nt. (total: 37,663 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 37,664
Label		BGC0001141

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001141	1.00	Polyketide	4-epi-15-epi-brefeldin A	Penicillium brefeldianum
BGC0002245	0.34	Terpene	terpestacin, preterpestacin 3, preterpestacin 2, preterpestacin 1	Bipolaris maydis C5
BGC0002228	0.34	NRP	CIML B, CIML A, CIML D, CIML C	Colletotrichum incanum
BGC0002610	0.33	Terpene	stellatic acid	Aspergillus stellatus
BGC0000670	0.33	Terpene	thalianol, thaliandiol	Arabidopsis thaliana
BGC0001893	0.32	Other	abscisic acid	Botrytis cinerea B05.10
BGC0002221	0.31	Terpene	ent-kauren-16alpha-ol	Serpula lacrymans var. lacrymans S7.9
BGC0001605	0.31	Terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0001262	0.31	Polyketide	AK-toxin I	Alternaria alternata
BGC0000677	0.31	Terpene	cyclooctatin	Streptomyces melanosporofaciens

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001141	1.00	Polyketide	4-epi-15-epi-brefeldin A	Penicillium brefeldianum
BGC0002245	0.67	Terpene	terpestacin, preterpestacin 3, preterpestacin 2, preterpestacin 1	Bipolaris maydis C5
BGC0002228	0.67	NRP	CIML B, CIML A, CIML D, CIML C	Colletotrichum incanum
BGC0002610	0.66	Terpene	stellatic acid	Aspergillus stellatus
BGC0000670	0.66	Terpene	thalianol, thaliandiol	Arabidopsis thaliana
BGC0001893	0.65	Other	abscisic acid	Botrytis cinerea B05.10
BGC0002221	0.65	Terpene	ent-kauren-16alpha-ol	Serpula lacrymans var. lacrymans S7.9
BGC0001605	0.65	Terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0001262	0.65	Polyketide	AK-toxin I	Alternaria alternata
BGC0000677	0.65	Terpene	cyclooctatin	Streptomyces melanosporofaciens

Similar known gene clusters from MIBiG 4.0

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 37663:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (pk)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

AIA58899.1

PKS_AT (559..872): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 75.0%; Methylmalonyl-CoA: 62.5%; 2-Methylbutyryl-CoA: 58.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 77.6
Methoxymalonyl-CoA: 68.7
Malonyl-CoA: 66.6
Ethylmalonyl-CoA: 44.9
Propionyl-CoA: 41.3
trans-1,2-CPDA: 38.2
Isobutyryl-CoA: 36.8
2-Methylbutyryl-CoA: 34.1
fatty_acid: 31.1
CHC-CoA: 22.1
Benzoyl-CoA: 14.5
3-Methylbutyryl-CoA: 14.4
Acetyl-CoA: 9.7
inactive: 0.0