BGC0001142 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001142 (Penicillium aethiopicum)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	59,698	tryptoquialanine	NRPS:Type I	100%

BGC0001142 - Region 1 - NRPS

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Location: 1 - 59,698 nt. (total: 59,698 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 59,699
Label		BGC0001142

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001142	1.00	NRP	tryptoquialanine	Penicillium aethiopicum
BGC0002710	0.32	NRP	metachelin C, metachelin A, metachelin A-CE, metachelin B, dimerumic acid 11-mannoside, dimerumic acid	Metarhizium robertsii ARSEF 23
BGC0000900	0.32	Other	ferrichrome	Aspergillus oryzae
BGC0001249	0.32	NRP	dimethylcoprogen	Alternaria alternata
BGC0000375	0.31	NRP	indigoidine	Streptomyces chromofuscus
BGC0002157	0.30	NRP, Alkaloid	(-)-ditryptophenaline	Aspergillus flavus
BGC0000457	0.30	NRP	vicibactin	Rhizobium etli CFN 42
BGC0000348	0.30	NRP	ergovaline	Epichloe festucae var. lolii
BGC0002248	0.29	Terpene, NRP	flavunoidine	Aspergillus flavus NRRL3357
BGC0000901	0.29	Other	ferrichrome	Aspergillus niger

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001142	1.00	NRP	tryptoquialanine	Penicillium aethiopicum
BGC0002710	0.66	NRP	metachelin C, metachelin A, metachelin A-CE, metachelin B, dimerumic acid 11-mannoside, dimerumic acid	Metarhizium robertsii ARSEF 23
BGC0000900	0.65	Other	ferrichrome	Aspergillus oryzae
BGC0001249	0.65	NRP	dimethylcoprogen	Alternaria alternata
BGC0000375	0.65	NRP	indigoidine	Streptomyces chromofuscus
BGC0002157	0.64	NRP, Alkaloid	(-)-ditryptophenaline	Aspergillus flavus
BGC0000457	0.63	NRP	vicibactin	Rhizobium etli CFN 42
BGC0000348	0.63	NRP	ergovaline	Epichloe festucae var. lolii
BGC0002248	0.63	Terpene, NRP	flavunoidine	Aspergillus flavus NRRL3357
BGC0000901	0.63	Other	ferrichrome	Aspergillus niger

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 59698:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X) + (X - D-Trp - Ala)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ADY16689.1

AMP-binding (55..449): X

nrpys: Aib

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: ala (Ala)

Stachelhaus prediction details:

Stachelhaus sequence:: DLFMMCGCIK
Nearest Stachelhaus code(s):: Aib DLFMMCGCIK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

ADY16697.1

Search NORINE for peptide: strict or relaxed

AMP-binding (284..690): X

nrpys: Ant

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: N/A
Single AA prediction:: ala (Ala)

Stachelhaus prediction details:

Stachelhaus sequence:: GVIFMAAGVK
Nearest Stachelhaus code(s):: Ant GVIFMAAGVK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1392..1795): Trp

nrpys: Trp

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DGMHVVGVSK
Nearest Stachelhaus code(s):: Trp DGMHVVGVSK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2981..3381): Ala

nrpys: Ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DMVIMAGALK
Nearest Stachelhaus code(s):: Ala DMVIMAGALK (100% 8Å match)
Stachelhaus code match:: 100% (strong)