BGC0001142: tryptoquialanine biosynthetic gene cluster from Penicillium aethiopicum
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Location: 1 - 59,698 nt. (total: 59,698 nt).
This entry is originally from NCBI GenBank HQ591508.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001142
Short description tryptoquialanine biosynthetic gene cluster from Penicillium aethiopicum
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
HQ591508.1
via
Compounds
  • tryptoquialanine
Species Penicillium aethiopicum [taxonomy]
References
Chemical products information
tryptoquialanine Evidence:
Copy SMILES
C27H26N4O7
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ADY16684.1
 283 - 1607 (-) hypothetical protein
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    • ADY16685.1
    		 3395 - 5346 (+) hypothetical protein
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      • ADY16686.1
      		 6261 - 8022 (+) hypothetical protein
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        • ADY16687.1
        		 8692 - 9797 (-) TqaC
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          • ADY16688.1
          		 10237 - 11778 (+) TqaD
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            • ADY16689.1
            		 12833 - 16159 (+) TqaB
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              • ADY16690.1
              		 16443 - 18062 (-) TqaE
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                • ADY16691.1
                		 18577 - 19633 (+) TqaM
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                  • ADY16692.1
                  		 19715 - 20431 (-) TqaF
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                    • ADY16693.1
                    		 21261 - 22758 (+) TqaK
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                      • ADY16694.1
                      		 23331 - 24446 (+) TqaL
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                        • ADY16695.1
                        		 25510 - 27232 (-) TqaG
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                          • ADY16696.1
                          		 28030 - 29574 (-) TqaH
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                            • ADY16697.1
                            		 30584 - 42893 (+) TqaA
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                              • ADY16698.1
                              		 43810 - 44619 (+) TqaI
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                                • ADY16699.1
                                		 45638 - 47489 (-) TqaJ
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                                  • ADY16700.1
                                  		 48947 - 50248 (-) hypothetical protein
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                                    • ADY16701.1
                                    		 52301 - 53119 (-) putative RTA1-like transmembrane protein
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                                      • ADY16702.1
                                      		 53873 - 55259 (+) putative Zn2Cys6 transcription factor
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                                        • ADY16703.1
                                        		 55454 - 57406 (-) hypothetical protein
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                                          • ADY16704.1
                                          		 57831 - 58406 (+) hypothetical protein
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                                            • ADY16705.1
                                            		 58720 - 59343 (+) hypothetical protein
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                                              Biosynthesis information

                                              Biosynthetic modules

                                              Name
                                              Unk01
                                              Type
                                              nrps-type1
                                              Genes
                                              ADY16689.1
                                              Substrates
                                              2-aminoisobutyric acid, D-alanine, alanine, D-2-aminobutyric acid (evidence: Structure-based inference, ATP-PPi exchange assay)
                                              Integrated Monomers
                                              Domains
                                              adenylation
                                              Name
                                              Unk02
                                              Type
                                              nrps-type1
                                              Genes
                                              ADY16697.1
                                              Substrates
                                              anthanillic acid (evidence: Structure-based inference [1])
                                              Integrated Monomers
                                              Domains
                                              adenylation
                                              Name
                                              Unk03
                                              Type
                                              nrps-type1
                                              Genes
                                              ADY16697.1
                                              Substrates
                                              tryptophan (evidence: Structure-based inference [1])
                                              Integrated Monomers
                                              Domains
                                              adenylation
                                              Name
                                              Unk04
                                              Type
                                              nrps-type1
                                              Genes
                                              ADY16697.1
                                              Substrates
                                              alanine (evidence: Structure-based inference [1])
                                              Integrated Monomers
                                              Domains
                                              adenylation
                                              Annotation changelog

                                              Entry version: 3

                                              Date
                                              Changes
                                              Submitters
                                              Reviewers
                                              2022-09-15
                                              Added NRP substrate specificities
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                              Entry version: 2

                                              Date
                                              Changes
                                              Submitters
                                              Reviewers
                                              2019-10-16
                                              Migrated from v1.4
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                              2019-10-16
                                              Updated compound(s) information (NPAtlas curation)
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                              Entry version: 1

                                              Date
                                              Changes
                                              Submitters
                                              Reviewers
                                              2015-06-12
                                              Submitted
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                              Detailed domain annotation
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