BGC0001143 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001143 (Aspergillus niger ATCC 1015)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	40,517	azanigerone A/azanigerone B/azanigerone C/azanigerone D/azanigerone E/azanigerone F	PKS	100%

BGC0001143 - Region 1 - T1PKS

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Location: 1 - 40,517 nt. (total: 40,517 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 40,518
Label		BGC0001143

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001143	1.00	Polyketide	azanigerone A, azanigerone B, azanigerone C, azanigerone D, azanigerone E, azanigerone F	Aspergillus niger ATCC 1015
BGC0000099	0.40	Polyketide	monascorubrin	Talaromyces marneffei
BGC0002194	0.35	Polyketide	epipyrone A	Epicoccum nigrum
BGC0002525	0.33	Polyketide	fusarubin, 1233A, 1233B, NG-391, lucilactaene	Fusarium sp.
BGC0000088	0.33	Polyketide	monacolin K	Aspergillus terreus
BGC0001252	0.33	Polyketide	UNII-YC2Q1O94PT	Alternaria alternata
BGC0002429	0.33	Terpene, Polyketide	higginsianin B	Colletotrichum higginsianum IMI 349063
BGC0002515	0.33	Polyketide	solanapyrone A	Ascochyta rabiei
BGC0000146	0.33	Polyketide	solanapyrone D	Alternaria solani
BGC0001606	0.32	Polyketide	gibepyrone-A	Fusarium fujikuroi IMI 58289

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001143	1.00	Polyketide	azanigerone A, azanigerone B, azanigerone C, azanigerone D, azanigerone E, azanigerone F	Aspergillus niger ATCC 1015
BGC0000099	0.72	Polyketide	monascorubrin	Talaromyces marneffei
BGC0002194	0.68	Polyketide	epipyrone A	Epicoccum nigrum
BGC0002525	0.67	Polyketide	fusarubin, 1233A, 1233B, NG-391, lucilactaene	Fusarium sp.
BGC0000088	0.66	Polyketide	monacolin K	Aspergillus terreus
BGC0001252	0.66	Polyketide	UNII-YC2Q1O94PT	Alternaria alternata
BGC0002429	0.66	Terpene, Polyketide	higginsianin B	Colletotrichum higginsianum IMI 349063
BGC0002515	0.66	Polyketide	solanapyrone A	Ascochyta rabiei
BGC0000146	0.66	Polyketide	solanapyrone D	Alternaria solani
BGC0001606	0.66	Polyketide	gibepyrone-A	Fusarium fujikuroi IMI 58289

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 40517:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (pk) + (Me-redmal)
Non-colinear ordering:: ASPNIDRAFT_56946 + ASPNIDRAFT_188817

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ASPNIDRAFT_188806

AMP-binding (21..441): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: AAPTRGVCIK
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)

ASPNIDRAFT_56946

PKS_AT (900..1196): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 70.8%; Ethylmalonyl-CoA: 54.2%; inactive: 54.2%

minowa: Methoxymalonyl-CoA

Prediction, score:

Methoxymalonyl-CoA: 60.7
Methylmalonyl-CoA: 49.7
Malonyl-CoA: 49.2
inactive: 44.2
trans-1,2-CPDA: 22.5
Propionyl-CoA: 22.4
Ethylmalonyl-CoA: 22.2
CHC-CoA: 21.8
Isobutyryl-CoA: 17.0
2-Methylbutyryl-CoA: 16.5
Benzoyl-CoA: 14.2
3-Methylbutyryl-CoA: 13.6
Acetyl-CoA: 11.0
fatty_acid: 0.0

ASPNIDRAFT_188817

PKS_AT (554..876): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 66.7%; Methylmalonyl-CoA: 62.5%; Isobutyryl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 90.9
Methylmalonyl-CoA: 66.1
Methoxymalonyl-CoA: 65.2
Isobutyryl-CoA: 29.8
Benzoyl-CoA: 22.3
inactive: 22.1
trans-1,2-CPDA: 17.0
fatty_acid: 16.3
CHC-CoA: 16.2
Propionyl-CoA: 15.7
2-Methylbutyryl-CoA: 14.7
Ethylmalonyl-CoA: 5.9
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0