Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001145.1:
Cluster 1RiPP115726

BGC0001145, cyclothiazomycin B biosynthetic gene cluster from Streptomyces mobaraensis. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: cyclothiazomycin B
PubChem ID: 56682060
SMILES string: Copy to clipboard
Molecular formula: C61H69N21O13S7
Average molecular mass: 1528.777 Da
Molecular activity: Antibacterial, Antifungal
Molecular target: fungal cell wall chitin,bacteriophage RNA polymerase

Class-specific details

Biosynthetic class(es):
RiPP
RiPP subclass:
Thiopeptide (cyclic)
Peptides in this cluster:
WP_004943468
RiPP core peptide sequence(s): SNCTSRGTPASCCSCCCC
Leader peptide length: 42
Follower peptide length: -1
Peptidase(s) involved in precursor cleavage:
Crosslinks in final product:
1=11 AA (Other)
5=18 AA (Thioether)

Gene cluster description

cyclothiazomycin B (BGC0001145). Gene Cluster 1. Biosynthetic class = RiPP. GenBank NZ_AORZ01000028, positions 35019-50744. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Detailed annotation

H340_11745 leader / core peptide, putative Class I
MEAKLELDLGDLSVEELDVLPTS - PGAGLEDhaINVGHAMVEIGADhaNCDhbDhaRGDhbPADhaCCDhaCCCC

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?unknown
Evidence for cluster-compound connection:Sequence-based prediction
MIxS-compliance:Unknown
Contact for this cluster:Douglas A. Mitchell (University of Illinois at Urbana-Champaign)

Literature references

1. Cox CL et al. (2014) Nucleophilic 1,4-additions for natural product discovery. ACS Chem Biol 9(9):2014-22. doi: 10.1021/cb500324n. Epub 2014 Jun
2. Mizuhara N et al. (2011) Antifungal thiopeptide cyclothiazomycin B1 exhibits growth inhibition accompanying morphological changes via binding to fungal cell wall chitin. Bioorg Med Chem 19(18):5300-10. doi: 10.1016/j.bmc.2011.08.010. Epub
3. Hashimoto M et al. (2006) An RNA polymerase inhibitor, cyclothiazomycin B1, and its isomer. Bioorg Med Chem 14(24):8259-70. doi: 10.1016/j.bmc.2006.09.006. Epub