Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001146.1:
Cluster 1RiPP112498

BGC0001146, cyclothiazomycin C biosynthetic gene cluster from Streptomyces sp. NRRL. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: cyclothiazomycin C
SMILES string: Copy to clipboard
Molecular formula: C60H67N19O13S7
Exact molecular mass: 1486.3309 Da ([M+H]+)
Molecular activity: Antibacterial

Class-specific details

Biosynthetic class(es):
RiPP subclass:
Thiopeptide (cyclic)
Peptides in this cluster:
RiPP core peptide sequence(s): SNCTSKGSPASCCSCCCC
Leader peptide length: 42
Follower peptide length: -1
Peptidase(s) involved in precursor cleavage:
Crosslinks in final product:
1=11 AA (Other)
5=18 AA (Thioether)

Gene cluster description

cyclothiazomycin C (BGC0001146). Gene Cluster 1. Biosynthetic class = RiPP. GenBank KJ651958. Click on genes for more information.


biosynthetic genes
transport-related genes
regulatory genes
other genes

Detailed annotation

ctmA leader / core peptide, putative Class I


Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?incomplete
Evidence for cluster-compound connection:Sequence-based prediction
Contact for this cluster:Douglas A. Mitchell (University of Illinois at Urbana-Champaign)

Literature references

1. Cox CL et al. (2014) Nucleophilic 1,4-additions for natural product discovery. ACS Chem Biol 9(9):2014-22. doi: 10.1021/cb500324n. Epub 2014 Jun