BGC0001148 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001148 (Streptomyces cirratus)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T3PKS,guanidinotides	1	28,927	pheganomycin	NRPS:Type I+ribosomal:RiPP	100%

BGC0001148 - Region 1 - T3PKS,guanidinotides

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Location: 1 - 28,927 nt. (total: 28,927 nt) Show pHMM detection rules used

Region on contig edge.

T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)
guanidinotides: (pgm1 and pgm_amidino)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

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TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 28,928
Label		BGC0001148

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001148	1.71	NRP, RiPP	pheganomycin	Streptomyces cirratus
BGC0001485	0.69	Alkaloid	chuangxinmycin	Actinoplanes tsinanensis
BGC0002127	0.69	Polyketide	flaviolin, 1,3,6,8-tetrahydroxynaphthalene	Streptomyces coelicolor A3(2)
BGC0002631	0.65	RiPP	myxarylin	Pyxidicoccus fallax
BGC0001849	0.58	RiPP	thiovarsolin A, thiovarsolin B, thiovarsolin C, thiovarsolin D	Streptomyces varsoviensis
BGC0002347	0.43	Alkaloid	cyanogramide, cyanogramide B, cyanogramide C, cyanogramide D	Actinoalloteichus cyanogriseus
BGC0001483	0.42	Other	5-isoprenylindole-3-carboxylate β-D-glycosyl ester	Streptomyces sp. RM-5-8
BGC0001223	0.42	Other	hydroxysporine	uncultured bacterium
BGC0000665	0.41	Terpene, Alkaloid	xiamycin	Streptomyces sp. HKI0576
BGC0002103	0.41	Other	pulcherriminic acid	Bacillus subtilis subsp. subtilis str. 168

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001148	0.99	NRP, RiPP	pheganomycin	Streptomyces cirratus
BGC0001485	0.68	Alkaloid	chuangxinmycin	Actinoplanes tsinanensis
BGC0002127	0.68	Polyketide	flaviolin, 1,3,6,8-tetrahydroxynaphthalene	Streptomyces coelicolor A3(2)
BGC0002631	0.66	RiPP	myxarylin	Pyxidicoccus fallax
BGC0001849	0.63	RiPP	thiovarsolin A, thiovarsolin B, thiovarsolin C, thiovarsolin D	Streptomyces varsoviensis
BGC0002347	0.60	Alkaloid	cyanogramide, cyanogramide B, cyanogramide C, cyanogramide D	Actinoalloteichus cyanogriseus
BGC0000632	0.58	Terpene, Saccharide	brasilicardin A	Nocardia terpenica
BGC0001641	0.56	NRP	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132	0.56	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001758	0.56	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454

Similar known gene clusters from MIBiG 4.0

NRPS/PKS substrates

NRPS/PKS substrate predictions

pgm21

Search NORINE for peptide: strict or relaxed

AMP-binding (163..553): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: DALWFGGTFK
Nearest Stachelhaus code(s):: Val DALWLGGTFK (82% 8Å match); bOH-Val DALWLGGTFK (76% 8Å match)
Stachelhaus code match:: 90% (moderate)