BGC0001149 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001149 (Pseudomonas sp. SHC52)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	12,786	brabantamide A	NRPS:Type I+saccharide:hybrid/tailoring	100%

BGC0001149 - Region 1 - NRPS

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Location: 1 - 12,786 nt. (total: 12,786 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 12,787
Label		BGC0001149

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001149	1.00	NRP, Saccharide	brabantamide A	Pseudomonas sp. SHC52
BGC0001873	0.41	NRP	pyrrolizixenamide A	Xenorhabdus szentirmaii DSM 16338
BGC0002075	0.32	NRP, Alkaloid	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0002518	0.29	NRP	syringafactin A, syringafactin C	Pseudomonas sp. SZ57
BGC0001833	0.27	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0001825	0.26	NRP	xenematide	Xenorhabdus nematophila AN6/1
BGC0001132	0.26	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001128	0.26	NRP	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286	0.25	NRP	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002135	0.25	NRP	bovienimide A	Xenorhabdus bovienii SS-2004

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001149	1.00	NRP, Saccharide	brabantamide A	Pseudomonas sp. SHC52
BGC0001873	0.72	NRP	pyrrolizixenamide A	Xenorhabdus szentirmaii DSM 16338
BGC0002075	0.65	NRP, Alkaloid	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0002518	0.63	NRP	syringafactin A, syringafactin C	Pseudomonas sp. SZ57
BGC0001833	0.61	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0001825	0.60	NRP	xenematide	Xenorhabdus nematophila AN6/1
BGC0001132	0.60	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001128	0.59	NRP	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286	0.59	NRP	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002135	0.59	NRP	bovienimide A	Xenorhabdus bovienii SS-2004

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 12786:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Ser - Pro)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

BN844_0706

Search NORINE for peptide: strict or relaxed

AMP-binding (468..871): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: ser (Ser)
Single AA prediction:: ser (Ser)

Stachelhaus prediction details:

Stachelhaus sequence:: DVWHLSLIDK
Nearest Stachelhaus code(s):: Ser DVWHLSLIDK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1533..1940): Pro

nrpys: Pro

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
Small clusters prediction:: pro (Pro)
Single AA prediction:: pro (Pro)

Stachelhaus prediction details:

Stachelhaus sequence:: DVQFSAHVVK
Nearest Stachelhaus code(s):: Pro DVQFSAHVVK (100% 8Å match); Piz DVQFSAHVVK (65% 8Å match)
Stachelhaus code match:: 100% (strong)