BGC0001150: pamamycin-607 biosynthetic gene cluster from Streptomyces alboniger
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Location: 1 - 23,437 nt. (total: 23,437 nt).
This entry is originally from NCBI GenBank KM923741.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
Operons
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001150
Short description pamamycin-607 biosynthetic gene cluster from Streptomyces alboniger
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Type II)
Loci
KM923741.1
via Knock-out studies, Enzymatic assays, Heterologous expression, Gene expression correlated with compound production
Compounds
  • pamamycin-607
  • pamamycin-621A
  • pamamycin-635G
  • pamamycin-663A
  • homopamamycin-677A
  • pamamycin-649B
Species Streptomyces alboniger [taxonomy]
References
Chemical products information
pamamycin-607 Evidence: NMR [3]
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C35H61N1O7
Chemical database entries
NPAtlas
pamamycin-621A Evidence: NMR [4], Total synthesis [1], Mass spectrometry [8]
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C36H63N1O7
Chemical database entries
NPAtlas
pamamycin-635G Evidence: NMR [5]
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C37H65N1O7
pamamycin-663A Evidence: NMR [5]
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C39H69N1O7
homopamamycin-677A Evidence: NMR [5]
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C40H71N1O7
pamamycin-649B Evidence: Total synthesis [2]
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C38H67N1O7
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • SALB_00464
  • AJS09379.1
  • pamR2
 13 - 750 (-) TetR family transcription regulator
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    • SALB_00465
    • AJS09380.1
    • pamW
    		 838 - 2514 (+) drug resistance transporter, EmrB/QacA family
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      • SALB_00466
      • AJS09381.1
      • pamC
      		 2611 - 2841 (-) acyl-carrier protein
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        • SALB_00467
        • AJS09382.1
        • pamG
        		 2895 - 3929 (-) Ketoacyl-acyl carrier protein synthase III
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          • SALB_00468
          • AJS09383.1
          • pamF
          		 3941 - 5260 (-) Ketoacyl-acyl carrier protein synthase II
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            • SALB_00469
            • AJS09384.1
            • pamA
            		 5472 - 6809 (+) Ketoacyl-acyl carrier protein synthase II
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              • SALB_00470
              • AJS09385.1
              • pamB
              		 6806 - 8668 (+) 3-ketoacid (adipate/glutaconate) CoA transferase
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                • SALB_00471
                • AJS09386.1
                • pamD
                		 8706 - 9665 (+) Ketoacyl-acyl carrier protein synthase III
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                  • SALB_00472
                  • AJS09387.1
                  • pamE
                  		 9718 - 10752 (+) Ketoacyl-acyl carrier protein synthase III
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                    • SALB_00473
                    • AJS09388.1
                    • pamO
                    		 10806 - 11600 (+) Ketoacyl-(acyl-carrier-protein) reductase
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                      • SALB_00474
                      • AJS09389.1
                      • pamK
                      		 11685 - 12695 (+) Ketoacyl-acyl carrier protein synthase III
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                        • SALB_00475
                        • AJS09390.1
                        • pamJ
                        		 12712 - 14007 (+) Ketoacyl-acyl carrier protein synthase II
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                          • SALB_00476
                          • AJS09391.1
                          • pamM
                          		 14000 - 15577 (+) Ketoacyl-(acyl-carrier-protein) reductase
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                            • SALB_00477
                            • AJS09392.1
                            • pamN
                            		 15574 - 16401 (+) Ketoacyl-(acyl-carrier-protein) reductase
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                              • SALB_00478
                              • AJS09393.1
                              • pamL
                              		 16398 - 18101 (+) Hydroxyl acids CoA ligase
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                                • SALB_00479
                                • AJS09394.1
                                • pamH
                                		 18085 - 19068 (+) Metal-dependent hydrolase (resistance)
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                                  • SALB_00480
                                  • AJS09395.1
                                  • pamX
                                  		 19165 - 20511 (+) Aminotransferase
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                                    • SALB_00481
                                    • AJS09396.1
                                    • pamY
                                    		 20560 - 21381 (+) Methyltransferase
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                                      • SALB_00482
                                      • AJS09397.1
                                      • pamS
                                      		 21599 - 22405 (+) Enoyl-CoA hydratase
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                                        • SALB_00483
                                        • AJS09398.1
                                        • pamR1
                                        		 22430 - 23077 (-) Response regulator LuxR family
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                                          Biosynthesis information
                                          Operons
                                          Genes Evidence
                                          pamC, pamG, pamFRNAseq
                                          pamH, pamN, pamJ, pamO, pamX, pamK, pamD, pamL, pamB, pamY, pamM, pamA, pamERNAseq
                                          Annotation changelog

                                          Entry version: next

                                          Date
                                          Changes
                                          Submitters
                                          Reviewers
                                          2024-04-23
                                          MIBiG v4 annotathon
                                          • (ID: Q4G2APLPZNOU4XV72H6GYP54)
                                          • (ID: 5SRAIADCX5E626OGO7LYHFZD)
                                          • (ID: YO3TP6VWB5CBNPZKNYNQSKUW)
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                          Entry version: 4

                                          Date
                                          Changes
                                          Submitters
                                          Reviewers
                                          2022-10-07
                                          Update chemical activity to schema version 2.11
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                          Entry version: 3

                                          Date
                                          Changes
                                          Submitters
                                          Reviewers
                                          2022-09-15
                                          Updated bioactivity data
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                          Entry version: 2

                                          Date
                                          Changes
                                          Submitters
                                          Reviewers
                                          2019-10-16
                                          Migrated from v1.4
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                          2019-10-16
                                          Updated compound(s) information (NPAtlas curation)
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                          Entry version: 1

                                          Date
                                          Changes
                                          Submitters
                                          Reviewers
                                          2015-06-12
                                          Submitted
                                          • (ID: YECXNWBIVB4ZABFMZK4W53HU)
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                          Detailed domain annotation
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