Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001150.1:
Cluster 1Polyketide123437

BGC0001150, pamamycin biosynthetic gene cluster from Streptomyces alboniger. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: pamamycin
PubChem ID: 10100233
SMILES string: Copy to clipboard
Molecular formula: C35H61NO7
Average molecular mass: 607.873 Da
Molecular activity: Antibacterial, Antifungal, Antioxidant, Cytotoxic, Inhibitor, Siderophore, Signalling, Surfactant, Other

Class-specific details

Biosynthetic class(es):
Polyketide
Polyketide subclass:
Other (linear)
Polyketide synthase subclass:
Type II / Type III
Starter unit:
Other
Polyketide synthase / ketosynthase-encoding genes:
SALB_00467,SALB_00468,SALB_00469,SALB_00471,SALB_00472,SALB_00474,SALB_00475

Gene cluster description

pamamycin (BGC0001150). Gene Cluster 1. Biosynthetic class = Polyketide. GenBank KM923741. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies, Enzymatic assays, Heterologous expression, Gene expression correlated with compound production
MIxS-compliance:Unknown
Contact for this cluster:Andriy Luzhetskyy (Helmholtz Institute for Pharmaceutical Sciences Saarland)

Literature references

1. Rebets Y et al. (2015) Insights into the pamamycin biosynthesis. Angew Chem Int Ed Engl 54(7):2280-4. doi: 10.1002/anie.201408901.