BGC0001151: valclavam biosynthetic gene cluster from Streptomyces antibioticus
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Location: 15,432 - 35,367 nt. (total: 19,936 nt).
This entry is originally from NCBI GenBank JN705801.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001151
Short description valclavam biosynthetic gene cluster from Streptomyces antibioticus
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Other (Non-NRP beta-lactam)
Loci NCBI GenBank: JN705801.1
Compounds
  • valclavam
  • (-)-2-(2-hydroxyethyl)clavam
Species Streptomyces antibioticus [taxonomy]
References
Chemical products information
valclavam
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C14H23N3O6
Chemical database entries
PubCHEM
PubCHEM
(-)-2-(2-hydroxyethyl)clavam
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C7H11N1O3
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AFH74309.1
  • psr
 15432 - 17963 (+) SanG
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  • AFH74310.1
  • atr
 18145 - 19548 (+) 4-aminobutyrate aminotransferase
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  • AFH74311.1
  • akr
 19529 - 20551 (+) Cvm1-like aldo/keto reductase
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  • AFH74312.1
  • hmt
 20655 - 21905 (-) OrfA-like hydroxymethyltransferase
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  • AFH74297.1
  • ceaS3
 22224 - 23939 (+) carboxyethylarginine synthase 3
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  • AFH74298.1
  • bls3
 23942 - 25465 (+) beta-lactam synthetase 3
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  • AFH74299.1
  • pah3
 25548 - 26510 (+) proclavaminate amidinohydrolase 3
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  • AFH74300.1
  • cas3
 26507 - 27481 (+) clavaminate synthase 3
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  • AFH74301.1
  • oat3
 27621 - 28805 (+) ornithine acetyltransferase 3
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  • AFH74302.1
  • oxr
 28882 - 29526 (-) oxidoreductase
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  • AFH74303.1
  • trn
 29628 - 30845 (-) major facilitator superfamily MFS_1 protein
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  • AFH74304.1
  • lig
 30883 - 32151 (-) ligase
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  • AFH74305.1
  • pah4
 32316 - 33230 (-) proclavaminate amidinohydrolase 4
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  • AFH74306.1
  • ctr
 33997 - 35367 (-) transcriptional regulator
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Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: SDHXYXULZ6ZTMHSITTYHRAHA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: 5UL74VURKJ25VSPPPO3H2NYB, no GDPR consent given).
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update compound structure (SMILES) for valclavam
  • Linked new PubChem id for valclavam (pubchem:441132)
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Similar known gene clusters
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