BGC0001151: valclavam biosynthetic gene cluster from Streptomyces antibioticus
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 15,432 - 35,367 nt. (total: 19,936 nt).
This entry is originally from NCBI GenBank JN705801.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001151
Short description valclavam biosynthetic gene cluster from Streptomyces antibioticus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • other (non-nrp beta-lactam)
Loci
JN705801.1
15432 - 35367
via Knock-out studies
Compounds
  • valclavam
  • (-)-2-(2-hydroxyethyl)clavam
Species Streptomyces antibioticus [taxonomy]
References
Chemical products information
valclavam Evidence:
Copy SMILES
C14H23N3O6
Chemical database entries
PubCHEM
PubCHEM
(-)-2-(2-hydroxyethyl)clavam Evidence:
Copy SMILES
C7H11N1O3
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AFH74309.1
  • psr
 15432 - 17963 (+) SanG
    copy AA seq
    copy Nt seq
    • AFH74310.1
    • atr
    		 18145 - 19548 (+) 4-aminobutyrate aminotransferase
      copy AA seq
      copy Nt seq
      • AFH74311.1
      • akr
      		 19529 - 20551 (+) Cvm1-like aldo/keto reductase
        copy AA seq
        copy Nt seq
        • AFH74312.1
        • hmt
        		 20655 - 21905 (-) OrfA-like hydroxymethyltransferase
          copy AA seq
          copy Nt seq
          • AFH74297.1
          • ceaS3
          		 22224 - 23939 (+) carboxyethylarginine synthase 3
            copy AA seq
            copy Nt seq
            • AFH74298.1
            • bls3
            		 23942 - 25465 (+) beta-lactam synthetase 3
              copy AA seq
              copy Nt seq
              • AFH74299.1
              • pah3
              		 25548 - 26510 (+) proclavaminate amidinohydrolase 3
                copy AA seq
                copy Nt seq
                • AFH74300.1
                • cas3
                		 26507 - 27481 (+) clavaminate synthase 3
                  copy AA seq
                  copy Nt seq
                  • AFH74301.1
                  • oat3
                  		 27621 - 28805 (+) ornithine acetyltransferase 3
                    copy AA seq
                    copy Nt seq
                    • AFH74302.1
                    • oxr
                    		 28882 - 29526 (-) oxidoreductase
                      copy AA seq
                      copy Nt seq
                      • AFH74303.1
                      • trn
                      		 29628 - 30845 (-) major facilitator superfamily MFS_1 protein
                        copy AA seq
                        copy Nt seq
                        • AFH74304.1
                        • lig
                        		 30883 - 32151 (-) ligase
                          copy AA seq
                          copy Nt seq
                          • AFH74305.1
                          • pah4
                          		 32316 - 33230 (-) proclavaminate amidinohydrolase 4
                            copy AA seq
                            copy Nt seq
                            • AFH74306.1
                            • ctr
                            		 33997 - 35367 (-) transcriptional regulator
                              copy AA seq
                              copy Nt seq
                              Biosynthesis information
                              Annotation changelog

                              Entry version: 4

                              Date
                              Changes
                              Submitters
                              Reviewers
                              2022-10-07
                              Update chemical activity to schema version 2.11
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                              Entry version: 3

                              Date
                              Changes
                              Submitters
                              Reviewers
                              2022-09-15
                              Update compound structure (SMILES) for valclavam
                              • (ID: 5UL74VURKJ25VSPPPO3H2NYB)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              2022-09-15
                              Linked new PubChem id for valclavam (pubchem:441132)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              2022-09-15
                              Updated bioactivity data
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                              Entry version: 2

                              Date
                              Changes
                              Submitters
                              Reviewers
                              2019-10-16
                              Migrated from v1.4
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              2019-10-16
                              Updated compound(s) information (NPAtlas curation)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                              Entry version: 1

                              Date
                              Changes
                              Submitters
                              Reviewers
                              2015-06-12
                              Submitted
                              • (ID: SDHXYXULZ6ZTMHSITTYHRAHA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              Similar known gene clusters from MIBiG 4.0
                              Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
                              Click on reference genes to show details of similarities to genes within the current region.
                              Click on an accession to open that entry in the MiBIG database.