BGC0001152: fusaricidin B biosynthetic gene cluster from Paenibacillus polymyxa
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Location: 10,739 - 42,549 nt. (total: 31,811 nt).
This entry is originally from NCBI GenBank EF451155.3.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001152
Short description fusaricidin B biosynthetic gene cluster from Paenibacillus polymyxa
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Unknown)
Loci
EF451155.3
10739 - 42549
via Knock-out studies
Compounds
  • fusaricidin B
Species Paenibacillus polymyxa [taxonomy]
References
Chemical products information
fusaricidin B Evidence:
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C42H76N10O11
Chemical database entries
NPAtlas
ChemSpider
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ACA34357.1
  • fusG
 10739 - 11473 (+) enoyl-acyl carrier protein reductase
  • Tailoring
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  • ACA34358.1
  • fusF
 11534 - 12946 (+) acyl-CoA ligase
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  • ACA34359.1
  • fusE
 12991 - 14214 (+) aldehyde dehydrogenase
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  • ACA34360.1
  • fusD
 14211 - 15911 (+) acetolactate synthase large subunit
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  • ACA34361.1
  • fusC
 16118 - 17176 (+) 3-oxoacyl-acyl carrier protein synthase
  • Tailoring
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  • ACA34362.1
  • fusB
 17181 - 17588 (+) (3R)-hydroxymyristoyl-acyl carrier protein dehydratase
  • Tailoring
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  • ABQ96384.2
  • fusA
 17682 - 41408 (+) fusaricidin synthetase
  • Scaffold biosynthesis
  • Knock-out
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  • ACA34363.1
  • fusTE
 41926 - 42549 (-) alpa/beta hydrolase-thioesterase
  • Scaffold biosynthesis
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Biosynthesis information

Biosynthetic modules

Name
2
Type
nrps-type1
Genes
fusA
Substrates
threonine (evidence: Sequence-based prediction)
Integrated Monomers
Domains
condensation (Starter), adenylation
Name
3
Type
nrps-type1
Genes
fusA
Substrates
valine (evidence: Sequence-based prediction)
Integrated Monomers
Domains
condensation (LCL), adenylation, epimerase
Name
4
Type
nrps-type1
Genes
fusA
Substrates
tyrosine (evidence: Structure-based inference [1], [2], [3])
Integrated Monomers
Domains
condensation (DCL), adenylation
Name
5
Type
nrps-type1
Genes
fusA
Substrates
threonine (evidence: Structure-based inference)
Integrated Monomers
Domains
condensation (LCL), adenylation, epimerase
Name
6
Type
nrps-type1
Genes
fusA
Substrates
asparagine (evidence: Sequence-based prediction)
Integrated Monomers
Domains
condensation (DCL), adenylation, epimerase
Name
7
Type
nrps-type1
Genes
fusA
Substrates
D-alanine (evidence: Activity assay)
Integrated Monomers
Domains
condensation (DCL), adenylation
Name
1
Type
pks-trans-at
Genes
fusC
Substrates
Integrated Monomers
Domains
ketosynthase
Annotation changelog

Entry version: 4

Date
Changes
Submitters
Reviewers
2022-10-07
Update chemical activity to schema version 2.11
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Entry version: 3

Date
Changes
Submitters
Reviewers
2022-09-15
Corrected NRP module activity
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2022-09-15
Removed ketoreductase stereochemistry annotation from modules without ketoreductases
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2022-09-15
Updated bioactivity data
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2022-09-15
Updated NRP substrate specificities
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Entry version: 2

Date
Changes
Submitters
Reviewers
2019-10-16
Migrated from v1.4
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2019-10-16
Updated compound(s) information (NPAtlas curation)
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Entry version: 1

Date
Changes
Submitters
Reviewers
2015-06-12
Submitted
  • (ID: SDHXYXULZ6ZTMHSITTYHRAHA)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
Detailed domain annotation
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