Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001152.1:
Cluster 1NRP131811

BGC0001152, fusaricidin biosynthetic gene cluster from Paenibacillus polymyxa. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: fusaricidin B
ChemSpider ID: 8923602
SMILES string: Copy to clipboard
Molecular formula:
Average molecular mass: Da
Molecular activity: Antifungal

Class-specific details

Biosynthetic class(es):
NRP
Nonribosomal peptide subclass:
Other lipopeptide (cyclic)
guanidinylated b-hydroxy fatty acid
Thioesterase type:
Type I & II
Release / cyclization type:
Macrolactonization

Nonribosomal peptide synthetases:
fusF (ACA34358.1)
Module 0
A specificity: None
Evidence for specificity: Sequence-based prediction
C domain subtype: N/A
fusA (ABQ96384.2)
Module 2
A specificity: Threonine
Evidence for specificity: Sequence-based prediction
C domain subtype: Starter
Module 3
A specificity: Valine
Evidence for specificity: Sequence-based prediction
AA is epimerized
C domain subtype: LCL
Module 4
A specificity: Tyrosine
Evidence for specificity: Sequence-based prediction
C domain subtype: DCL
Module 5
A specificity: Allo-threonine
Evidence for specificity: Sequence-based prediction
AA is epimerized
C domain subtype: LCL
Module 6
A specificity: Asparigine
Evidence for specificity: Sequence-based prediction
AA is epimerized
C domain subtype: DCL
Module 7
A specificity: D-alanine
Evidence for specificity: Activity assay
C domain subtype: DCL

Gene cluster description

fusaricidin (BGC0001152). Gene Cluster 1. Biosynthetic class = NRP. GenBank EF451155, positions 10739-42549. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies, Sequence-based prediction
MIxS-compliance:Unknown
Contact for this cluster:Susan Jensen (University of Alberta)

Literature references

1. Li J et al. (2007) Use of PCR-targeted mutagenesis to disrupt production of fusaricidin-type antifungal antibiotics in Paenibacillus polymyxa. Appl Environ Microbiol 73(11):3480-9. doi: 10.1128/AEM.02662-06. Epub
2. Li J, Jensen SE. (2008) Nonribosomal biosynthesis of fusaricidins by Paenibacillus polymyxa PKB1 involves direct activation of a D-amino acid. Chem Biol 15(2):118-27. doi: 10.1016/j.chembiol.2007.12.014.