BGC0001153: polymyxin B biosynthetic gene cluster from Paenibacillus polymyxa
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Location: 1 - 40,826 nt. (total: 40,826 nt).
This entry is originally from NCBI GenBank JN660148.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001153
Short description polymyxin B biosynthetic gene cluster from Paenibacillus polymyxa
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
JN660148.1
1 - 40826
via Knock-out studies
Compounds
  • polymyxin B
Species Paenibacillus polymyxa [taxonomy]
References
Chemical products information
polymyxin B Evidence:
Copy SMILES
C56H98N16O13
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AEZ51516.1
  • pmxA
 9 - 14765 (+) pmxA
  • Scaffold biosynthesis
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  • AEZ51517.1
  • pmxB
 14920 - 18228 (+) pmxB
  • Scaffold biosynthesis
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  • AEZ51518.1
  • pmxC
 18218 - 20044 (+) pmxC
  • Transport
  • Knock-out
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  • AEZ51519.1
  • pmxD
 20041 - 21774 (+) pmxD
  • Transport
  • Knock-out
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  • AEZ51520.1
  • pmxE
 22005 - 40826 (+) pmxE
  • Scaffold biosynthesis
  • Knock-out
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Biosynthesis information

Biosynthetic modules

Name
0
Type
nrps-type1
Genes
pmxE
Substrates
2,4-diaminobutyric acid (evidence: Sequence-based prediction)
Integrated Monomers
Domains
condensation (Starter), adenylation
Name
1
Type
nrps-type1
Genes
pmxE
Substrates
threonine (evidence: Sequence-based prediction)
Integrated Monomers
Domains
condensation (LCL), adenylation
Name
2
Type
nrps-type1
Genes
pmxE
Substrates
2,4-diaminobutyric acid (evidence: Sequence-based prediction)
Integrated Monomers
Domains
condensation (LCL), adenylation, epimerase
Name
3
Type
nrps-type1
Genes
pmxE
Substrates
2,4-diaminobutyric acid (evidence: Sequence-based prediction)
Integrated Monomers
Domains
condensation (DCL), adenylation
Name
4
Type
nrps-type1
Genes
pmxE
Substrates
2,4-diaminobutyric acid (evidence: Sequence-based prediction)
Integrated Monomers
Domains
condensation (LCL), adenylation
Name
6
Type
nrps-type1
Genes
pmxA
Substrates
phenylalanine (evidence: Sequence-based prediction)
Integrated Monomers
Domains
adenylation, epimerase
Name
7
Type
nrps-type1
Genes
pmxA
Substrates
leucine (evidence: Sequence-based prediction)
Integrated Monomers
Domains
condensation (DCL), adenylation
Name
8
Type
nrps-type1
Genes
pmxA
Substrates
2,4-diaminobutyric acid (evidence: Sequence-based prediction)
Integrated Monomers
Domains
condensation (LCL), adenylation
Name
9
Type
nrps-type1
Genes
pmxA
Substrates
2,4-diaminobutyric acid (evidence: Sequence-based prediction)
Integrated Monomers
Domains
condensation (LCL), adenylation
Name
11
Type
nrps-type1
Genes
pmxB
Substrates
threonine (evidence: Sequence-based prediction)
Integrated Monomers
Domains
adenylation
Annotation changelog

Entry version: 4

Date
Changes
Submitters
Reviewers
2022-10-07
Update chemical activity to schema version 2.11
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  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

Entry version: 3

Date
Changes
Submitters
Reviewers
2022-09-15
Corrected NRP module activity
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
2022-09-15
Updated bioactivity data
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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2022-09-15
Updated NRP substrate specificities
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Entry version: 2

Date
Changes
Submitters
Reviewers
2019-10-16
Migrated from v1.4
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  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

Entry version: 1

Date
Changes
Submitters
Reviewers
2015-06-12
Submitted
  • (ID: SDHXYXULZ6ZTMHSITTYHRAHA)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
Detailed domain annotation
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