BGC0001153: polymyxin B biosynthetic gene cluster from Paenibacillus polymyxa
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Location: 1 - 40,826 nt. (total: 40,826 nt).
This entry is originally from NCBI GenBank JN660148.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001153
Short description polymyxin B biosynthetic gene cluster from Paenibacillus polymyxa
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP (Other lipopeptide)
Loci NCBI GenBank: JN660148.1
Compounds
  • polymyxin B
Species Paenibacillus polymyxa [taxonomy]
References
Chemical products information
polymyxin B [synonyms: d-dab polymyxin b]
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C56H98N16O13
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AEZ51516.1
  • pmxA
 9 - 14765 (+) pmxA
  • Scaffold biosynthesis
Sequence-based prediction
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  • AEZ51517.1
  • pmxB
 14920 - 18228 (+) pmxB
  • Scaffold biosynthesis
Sequence-based prediction
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  • AEZ51518.1
  • pmxC
 18218 - 20044 (+) pmxC
  • Transport
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  • AEZ51519.1
  • pmxD
 20041 - 21774 (+) pmxD
  • Transport
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  • AEZ51520.1
  • pmxE
 22005 - 40826 (+) pmxE
  • Scaffold biosynthesis
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NRP-specific information
Subclass Other lipopeptide
Cyclic? yes
Release type
  • Macrolactamization
Lipid moiety isooctanoic acid
Thioesterase genes
  • pmxB (Type I)
NRP-synthases
Gene Modules
pmxE
Module 0
Specificity: 2,4-diaminobutyric acid
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: Starter
Module 1
Specificity: threonine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: LCL
Module 2
Specificity: 2,4-diaminobutyric acid
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: LCL
Module 3
Specificity: 2,4-diaminobutyric acid
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: DCL
Module 4
Specificity: 2,4-diaminobutyric acid
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: LCL
Module 5
Condensation domain type: LCL
pmxA
Module 10
Condensation domain type: LCL
Module 6
Specificity: phenylalanine
Evidence for specificity:
  • Sequence-based prediction
Module 7
Specificity: leucine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: DCL
Module 8
Specificity: 2,4-diaminobutyric acid
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: LCL
Module 9
Specificity: 2,4-diaminobutyric acid
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: LCL
pmxB
Module 11
Specificity: threonine
Evidence for specificity:
  • Sequence-based prediction
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: SDHXYXULZ6ZTMHSITTYHRAHA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Corrected NRP module activity
  • Updated bioactivity data
  • Updated NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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