LOCUS       BGC0001154             25392 bp    DNA     circular BCT 10-SEP-2019
DEFINITION  Catenulispora acidiphila DSM 44928 chromosome, complete genome.
ACCESSION   BGC0001154
VERSION     BGC0001154
KEYWORDS    .
SOURCE      Catenulispora acidiphila DSM 44928
  ORGANISM  Catenulispora acidiphila DSM 44928
            Bacteria; Actinomycetota; Actinomycetes; Catenulisporales;
            Catenulisporaceae; Catenulispora.
REFERENCE   1  (bases 1 to 10467782)
  AUTHORS   Copeland,A., Lapidus,A., Glavina Del Rio,T., Nolan,M., Lucas,S.,
            Chen,F., Tice,H., Cheng,J.F., Bruce,D., Goodwin,L., Pitluck,S.,
            Mikhailova,N., Pati,A., Ivanova,N., Mavromatis,K., Chen,A.,
            Palaniappan,K., Chain,P., Land,M., Hauser,L., Chang,Y.J.,
            Jeffries,C.D., Chertkov,O., Brettin,T., Detter,J.C., Han,C., Ali,Z.,
            Tindall,B.J., Goker,M., Bristow,J., Eisen,J.A., Markowitz,V.,
            Hugenholtz,P., Kyrpides,N.C. and Klenk,H.P.
  TITLE     Complete genome sequence of Catenulispora acidiphila type strain (ID
            139908)
  JOURNAL   Stand Genomic Sci 1 (2), 119-125 (2009)
   PUBMED   21304647
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10467782)
  AUTHORS   Lucas,S., Copeland,A., Lapidus,A., Glavina del Rio,T., Dalin,E.,
            Tice,H., Bruce,D., Goodwin,L., Pitluck,S., Kyrpides,N.,
            Mavromatis,K., Ivanova,N., Mikhailova,N., Chertkov,O., Brettin,T.,
            Detter,J.C., Han,C., Larimer,F., Land,M., Hauser,L., Markowitz,V.,
            Cheng,J.-F., Hugenholtz,P., Woyke,T., Wu,D., Klenk,H.-P. and
            Eisen,J.A.
  CONSRTM   US DOE Joint Genome Institute (JGI-PGF)
  TITLE     The complete genome of Catenulispora acidiphila DSM 44928
  JOURNAL   Unpublished
REFERENCE   3  (bases 1 to 10467782)
  AUTHORS   Lucas,S., Copeland,A., Lapidus,A., Glavina del Rio,T., Dalin,E.,
            Tice,H., Bruce,D., Goodwin,L., Pitluck,S., Kyrpides,N.,
            Mavromatis,K., Ivanova,N., Mikhailova,N., Chertkov,O., Brettin,T.,
            Detter,J.C., Han,C., Larimer,F., Land,M., Hauser,L., Markowitz,V.,
            Cheng,J.-F., Hugenholtz,P., Woyke,T., Wu,D., Klenk,H.-P. and
            Eisen,J.A.
  CONSRTM   US DOE Joint Genome Institute (JGI-PGF)
  TITLE     Direct Submission
  JOURNAL   Submitted (12-AUG-2009) US DOE Joint Genome Institute, 2800 Mitchell
            Drive, Walnut Creek, CA 94598-1698, USA
COMMENT     ##Metadata-START##
            Organism Display Name :: Catenulispora acidiphila ID139908, DSM
            44928
            Culture Collection ID :: DSM 44928, NRRL B-24433, JCM 14897
            GOLD Stamp ID         :: Gi02233
            Funding Program       :: DOE-GEBA 2007
            Gene Calling Method   :: Prodigal
            Isolation Site        :: Forest soil from Gerenzano Italy
            Collection Date       :: before 2006
            Isolation Country     :: Italy
            Oxygen Requirement    :: Aerobe
            Cell Shape            :: Filament-shaped
            Motility              :: Nonmotile
            Sporulation           :: Sporulating
            Temperature Range     :: Mesophile
            Temperature Optimum   :: 22 - 28C
            pH                    :: 6
            Gram Staining         :: gram+
            Biotic Relationship   :: Free living
            Diseases              :: None
            Habitat               :: Soil
            Phenotypes            :: Acidophile
            ##Metadata-END##
            ##antiSMASH-Data-START##
            Version               :: 8.dev-5707d64f
            Run date              :: 2025-08-15 18:46:06
            NOTE :: This is a single region extracted from a larger record!
            Orig. start           :: 0
            Orig. end             :: 25392
            ##antiSMASH-Data-END##
            URL -- http://www.jgi.doe.gov
            JGI Project ID: 4082785
            Source DNA and organism available from Hans-Peter Klenk at the
            German Collection of Microorganisms and Cell Cultures (DSMZ)
            (hans-peter.klenk@dsmz.de)
            Contacts: Jonathan A. Eisen (jaeisen@ucdavis.edu)
            David Bruce (microbe@cuba.jgi-psf.org)
            Whole genome sequencing and draft assembly at JGI-PGF
            Finishing done by JGI-LANL
            Annotation by JGI-ORNL and JGI-PGF
            The JGI and collaborators endorse the principles for the
            distribution and use of large scale sequencing data adopted by the
            larger genome sequencing community and urge users of this data to
            follow them. It is our intention to publish the work of this
            project in a timely fashion and we welcome collaborative
            interaction on the project and analysis.
            (http://www.genome.gov/page.cfm?pageID=10506376).
FEATURES             Location/Qualifiers
     region          1..25392
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="aminocoumarin"
                     /region_number="1"
                     /rules="(novK or novJ or novI or novH or SpcDK_cou)"
                     /subregion_numbers="1"
                     /tool="antismash"
     subregion       1..25392
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0001154"
                     /subregion_number="1"
                     /tool="antismash"
     cand_cluster    1..25392
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(novK or novJ or novI or novH or
                     SpcDK_cou)"
                     /kind="single"
                     /product="aminocoumarin"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25392
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[10000:15392](-)"
                     /cutoff="20000"
                     /detection_rule="(novK or novJ or novI or novH or
                     SpcDK_cou)"
                     /neighbourhood="10000"
                     /product="aminocoumarin"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..15392)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(novK or novJ or novI or novH or
                     SpcDK_cou)"
                     /neighbourhood="10000"
                     /product="aminocoumarin"
                     /protocluster_number="1"
     gene            complement(501..1904)
                     /locus_tag="Caci_2710"
     gene            complement(1914..2666)
                     /locus_tag="Caci_2711"
     gene            complement(2703..3242)
                     /locus_tag="Caci_2712"
     gene            complement(3403..4437)
                     /locus_tag="Caci_2713"
     gene            complement(4516..5835)
                     /locus_tag="Caci_2714"
     CDS             complement(4516..5835)
                     /codon_start=1
                     /db_xref="InterPro:IPR006153"
                     /gene_functions="transport (smcogs) SMCOG1117:
                     sodium/hydrogen exchanger"
                     /gene_kind="transport"
                     /inference="protein motif:PFAM:PF00999"
                     /locus_tag="Caci_2714"
                     /note="PFAM: sodium/hydrogen exchanger; KEGG: fal:FRAAL1809
                     Na+/H+ antiporter"
                     /product="sodium/hydrogen exchanger"
                     /protein_id="ACU71629.1"
                     /transl_table=11
                     /translation="MAFAVAPDAVLAGEVAVAIVAAWAARTAARPLRQSAVVVEILAGV
                     ALGPSLLGLLPGDPTGRLFPASGRGTLTSVAELGLLLFMFAIGWELDVSVVRARRTATI
                     AMTAANFVVPFAVGAALAFALYPAYAGTRSGHRVTEAVFVVYIGVALAITAFPVLARIL
                     GDSPLRNTPVGQTAMAMAAGTDLCGWLGLALVVIAASATGSAASWTTLPLVVVYLAAMF
                     LIVRPLLRTALAHVRAVGSGGTLPLVVAAVLASSYVSSAAGLHAAFGAFLLGLVMPRDS
                     RAVLMLDIAEPLERTGAILMPVYFVATGLSADFHTLGWAGFELGFGVVALASTAKIGAV
                     AAAARICGTDRREALILGVLMNTRGLTEIVVLDIGLSIGIIDAHLFTALLLMAVATTAV
                     TTPVLHRLTSAASPATPAPWRPGSRPDRDAPSPSGPARTA"
     gene            complement(5842..7116)
                     /locus_tag="Caci_2715"
     CDS             complement(5842..7116)
                     /codon_start=1
                     /db_xref="InterPro:IPR006076"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1103: FAD dependent oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="protein motif:PFAM:PF01266"
                     /locus_tag="Caci_2715"
                     /note="PFAM: FAD dependent oxidoreductase; KEGG:
                     sen:SACE_2961 fructosyl-amino acid oxidase, putative"
                     /product="FAD dependent oxidoreductase"
                     /protein_id="ACU71630.1"
                     /sec_met_domain="DAO (E-value: 1.2e-43, bitscore: 139.9,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRNRPRVVVVGGGVLGTCIAGACAARSARVTLLDAAVPGSGTSST
                     SFAWANAQKKRPESYFRLNAEGLAEYHRLARAGVGSGWFHAVGNVEVAVDAASAEALEA
                     NVADLAARGYAAENVSARRAADLEPLIDPDRIAAAAYFPDEGWVDAEEMVSDALADVRA
                     GTGVIRTHHAVVGFEPAGAGTKVLLADGEELLADYVVCATGTATEALLAGSGIAVPMIS
                     ETARKPRASGGEGREGSPDERYTAVGGLAFTAPLRSPLRRIVHTPDMGLRPSAYGRAVL
                     GGDGAGSRVPRNDPAVFENGPRLLERARRLFPAMAEVTLDAVRVGVRPMPADGLTVAGF
                     TESVPGLYVVVTHSGITLAQYLARLVAGEVLGSKEAAALADFRPGRFAAARLEDVAPAD
                     KGSAEKGSAEKAPVEEGLVGDRKRG"
     sig_peptide     complement(7042..7116)
                     /locus_tag="Caci_2715"
                     /note="Signal predicted by SignalP 3.0 HMM (Signal peptide
                     probability 0.987) with cleavage site probability 0.420 at
                     residue 25"
     gene            complement(7113..8396)
                     /locus_tag="Caci_2716"
     CDS             complement(7113..8396)
                     /codon_start=1
                     /db_xref="InterPro:IPR001926"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PALP"
                     /gene_kind="biosynthetic-additional"
                     /inference="protein motif:PFAM:PF00291"
                     /locus_tag="Caci_2716"
                     /note="PFAM: Pyridoxal-5'-phosphate-dependent protein beta
                     subunit; KEGG: hsl:OE1807R threonine synthase"
                     /product="Pyridoxal-5'-phosphate-dependent protein beta
                     subunit"
                     /protein_id="ACU71631.1"
                     /sec_met_domain="PALP (E-value: 1.5e-41, bitscore: 132.5,
                     seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAEFIGNYESLIRKVRGSAGDGTSGAGDTNSAGEAGSAKVIRYFC
                     VRCEHEFIEPAFNKCTECGGAIDAIYDLDQVQIPAEKQGPDPLQHYFSLLPVRERSSLH
                     WGGEGNTPCFQVPELASALGIAQLYFKNEAVNPTSSTKDRVASVCLSRFGELGVRDLVL
                     SSTGNSSTAYARAVSLVPGFTLHIFVGREFVSRLNYADHPRIVTHVVDGEFVTAGRVGE
                     RFAQDNGFFWEGGFFNLGRREGLKLAYLEAYDEMQAEPDYVFQAVSSGMGLVGAYKGAV
                     EYRELGRLGKVPSFMAVQQASCSPMAQAFAEDADQIAPRHVVRDPKGLAYAILRGDPTG
                     TYPYIRDLCLTSGGRILAAGEERIRHARRVLAETVGVDVCFASSTAFAGVLEAAEAGLL
                     APDSVVLVNLTGADRPAAQVATIGRTHA"
     gene            complement(8363..9997)
                     /locus_tag="Caci_2717"
     CDS             complement(8363..9997)
                     /NRPS_PKS="Domain: AMP-binding (15-429). E-value: 6.5e-68.
                     Score: 221.1. Matches aSDomain:
                     nrpspksdomains_Caci_2717_AMP-binding.1"
                     /codon_start=1
                     /db_xref="InterPro:IPR000873"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="protein motif:PFAM:PF00501"
                     /locus_tag="Caci_2717"
                     /note="PFAM: AMP-dependent synthetase and ligase; KEGG:
                     fra:Francci3_4204 AMP-dependent synthetase and ligase"
                     /product="AMP-dependent synthetase and ligase"
                     /protein_id="ACU71632.1"
                     /sec_met_domain="AMP-binding (E-value: 4e-72, bitscore:
                     232.8, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKDPGHYVARILDQLALDDDRPVIRWQDTVVPAAELRSALIRVAT
                     ALRRLDVGSDDTVAVLTSVNSPWMLATRYAVHLVGATVVYVSGSNHGTTTHGLTRQTRA
                     RMVHETGASVLLFDEDNAAEADGIRALLASRSEVRLCALGTPLSGPVSIDGSPVAEPTT
                     TTATGSAASTIDLTPHTPTRAMVIYTSGSTGSPKGVVKPFVAWNNVVLNEATFTSAKTF
                     LAVSAVSHTGGLLTDMAIASGGSALLRTAFEPAAFLRDIAEYRVTDTLIGVPLLYQLTN
                     HPDAPTTDLSSLRRLLYIGCAASPERVREAVKVFPGVLHHSYGTTETGQIAMLTAADHD
                     VAELLDTVGRPRTDLTVAVRDPRTGRGLPAGQLGEVVVRGANNMLGYAADPDLTARVLR
                     DGWVHTGDLGRIGDNGYLRLFGRMDDVVKVHDTRVHPIEVEKVLAGHPGVADACVWGRQ
                     GPDLLGELHAAVVLREDDPPAREALRGHVAALMTPTHVPATLTRWRAFPINVNGKVDRV
                     LVREQSSHPEAGRDEPAWPNSSETTKA"
     CDS_motif       complement(8678..8740)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Caci_2717_0003"
                     /evalue="1.90E-04"
                     /label="NRPS-A_a8"
                     /locus_tag="Caci_2717"
                     /protein_end="440"
                     /protein_start="419"
                     /score="14.2"
                     /tool="antismash"
                     /translation="FGRMDDVVKVHDTRVHPIEVE"
     aSDomain        complement(8711..9952)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_Caci_2717_AMP-binding.1"
                     /evalue="6.50E-68"
                     /label="Caci_2717_AMP-binding.1"
                     /locus_tag="Caci_2717"
                     /protein_end="429"
                     /protein_start="15"
                     /score="221.1"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="ALDDDRPVIRWQDTVVPAAELRSALIRVATALRRLDVGSDDTVAV
                     LTSVNSPWMLATRYAVHLVGATVVYVSGSNHGTTTHGLTRQTRARMVHETGASVLLFDE
                     DNAAEADGIRALLASRSEVRLCALGTPLSGPVSIDGSPVAEPTTTTATGSAASTIDLTP
                     HTPTRAMVIYTSGSTGSPKGVVKPFVAWNNVVLNEATFTSAKTFLAVSAVSHTGGLLTD
                     MAIASGGSALLRTAFEPAAFLRDIAEYRVTDTLIGVPLLYQLTNHPDAPTTDLSSLRRL
                     LYIGCAASPERVREAVKVFPGVLHHSYGTTETGQIAMLTAADHDVAELLDTVGRPRTDL
                     TVAVRDPRTGRGLPAGQLGEVVVRGANNMLGYAADPDLTARVLRDGWVHTGDLGRIGDN
                     GYLRLFGRMDDVVKV"
     CDS_motif       complement(8810..8893)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Caci_2717_0002"
                     /evalue="1.10E-05"
                     /label="NRPS-A_a6"
                     /locus_tag="Caci_2717"
                     /protein_end="396"
                     /protein_start="368"
                     /score="17.9"
                     /tool="antismash"
                     /translation="PAGQLGEVVVRGANNMLGYAADPDLTAR"
     CDS_motif       complement(9398..9448)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Caci_2717_0001"
                     /evalue="6.60E-08"
                     /label="NRPS-A_a3"
                     /locus_tag="Caci_2717"
                     /protein_end="200"
                     /protein_start="183"
                     /score="24.8"
                     /tool="antismash"
                     /translation="AMVIYTSGSTGSPKGVV"
     gene            complement(10001..10783)
                     /locus_tag="Caci_2718"
     CDS             complement(10001..10783)
                     /codon_start=1
                     /db_xref="InterPro:IPR002347"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     aminocoumarin: novK"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic"
                     /inference="similar to AA sequence:KEGG:MAV_1395"
                     /locus_tag="Caci_2718"
                     /note="KEGG: mav:MAV_1395 2-hydroxycyclohexanecarboxyl-CoA
                     dehydrogenase"
                     /product="2-hydroxycyclohexanecarboxyl-CoA dehydrogenase"
                     /protein_id="ACU71633.1"
                     /sec_met_domain="novK (E-value: 3.6e-117, bitscore: 380.0,
                     seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGLTAAAGQTGALSRMAVVAGGACDTGLAAALQLAELGLDVALI
                     GADVAVPVEVTERFFAGGRHCLAIRADLADGRSFAAALGGARSVLGSPSVLVNCVPLGG
                     PEPLSAEERYADARRSLRALFACCRAVCAHMVRNRWGRIVNIAQPAVADGAADREWRDG
                     QTVLGGLVGFTRSAALELAAYGVTANYIAPSSCYPAGPAHAPAPPPAAAAGGGGTGPSY
                     AAGVAALTGFLISDQASAITGQGGYLAGRPAAPSARWE"
     gene            complement(10780..11274)
                     /locus_tag="Caci_2719"
     CDS             complement(10780..11274)
                     /codon_start=1
                     /inference="similar to AA sequence:KEGG:NCU05096"
                     /locus_tag="Caci_2719"
                     /note="KEGG: hypothetical protein"
                     /product="conserved hypothetical protein"
                     /protein_id="ACU71634.1"
                     /transl_table=11
                     /translation="MSRRSVLCGGASRFGSASRFGEASRFGGASRFSGASEFGGASFSG
                     GASRFGGASRFGGASRFGGASRFSGASEFGEVSLFGGRLVGGASTAGEASVSGGSLFGG
                     ANSATEASLFGKSLIGGASTVGGASFSGESLFGGASTVGKASISGARRRLPAACGEGGS
                     R"
     sig_peptide     complement(11209..11274)
                     /locus_tag="Caci_2719"
                     /note="Signal predicted by SignalP 3.0 HMM (Signal peptide
                     probability 0.735) with cleavage site probability 0.655 at
                     residue 22"
     gene            complement(11271..12038)
                     /locus_tag="Caci_2720"
     CDS             complement(11271..12038)
                     /NRPS_PKS="Domain: PKS_KR (10-183). E-value: 4.1e-23.
                     Score: 74.2. Matches aSDomain:
                     nrpspksdomains_Caci_2720_PKS_KR.1"
                     /codon_start=1
                     /db_xref="InterPro:IPR002198"
                     /db_xref="InterPro:IPR002347"
                     /db_xref="InterPro:IPR013968"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     aminocoumarin: novJ"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic"
                     /inference="protein motif:PFAM:PF00106"
                     /locus_tag="Caci_2720"
                     /note="PFAM: short-chain dehydrogenase/reductase SDR; KR
                     domain protein; KEGG: sen:SACE_5381 putative
                     3-oxoacyl-[acyl- carrier protein] reductase"
                     /product="short-chain dehydrogenase/reductase SDR"
                     /protein_id="ACU71635.1"
                     /sec_met_domain="novJ (E-value: 6.5e-139, bitscore: 451.3,
                     seeds: 5, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short (E-value: 3.4e-36, bitscore:
                     114.8, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short_C2 (E-value: 1.4e-32, bitscore:
                     103.4, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRTPDGTGTVAVVTGAARGIGAAVALRLAAGGATVVVVDREERD
                     TAGTVAAVRRAGGRALGIGCDVAVAAEVRTAMLRIAAAYGRLDILVNCAGVTRDRLLLA
                     MDDPEWDTVLDVSLGGTMRWSLAAAELMKHRGTGRIVTFSSVAADGNPGQSNYATAKAA
                     LAGFTRALASELGPHGITVNAVAPGFVATPMVAELADRLGVDREAFLKEAASHAAVGRV
                     GTVDDIAAVVAFLTGRDSGYLTGQTVSVDGGRR"
     aSDomain        complement(11490..12008)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_Caci_2720_PKS_KR.1"
                     /evalue="4.10E-23"
                     /label="Caci_2720_PKS_KR.1"
                     /locus_tag="Caci_2720"
                     /protein_end="183"
                     /protein_start="10"
                     /score="74.2"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VAVVTGAARGIGAAVALRLAAGGATVVVVDREERDTAGTVAAVRR
                     AGGRALGIGCDVAVAAEVRTAMLRIAAAYGRLDILVNCAGVTRDRLLLAMDDPEWDTVL
                     DVSLGGTMRWSLAAAELMKHRGTGRIVTFSSVAADGNPGQSNYATAKAALAGFTRALAS
                     ELGPHGITVN"
     CDS_motif       complement(11532..11618)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Caci_2720_0002"
                     /evalue="2.30E-07"
                     /label="PKSI-KR_m4"
                     /locus_tag="Caci_2720"
                     /protein_end="169"
                     /protein_start="140"
                     /score="23.3"
                     /tool="antismash"
                     /translation="VTFSSVAADGNPGQSNYATAKAALAGFTR"
     CDS_motif       complement(11916..12002)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Caci_2720_0001"
                     /evalue="3.90E-05"
                     /label="PKSI-KR_m1"
                     /locus_tag="Caci_2720"
                     /protein_end="41"
                     /protein_start="12"
                     /score="16.3"
                     /tool="antismash"
                     /translation="VVTGAARGIGAAVALRLAAGGATVVVVDR"
     gene            complement(12035..12349)
                     /locus_tag="Caci_2721"
     CDS             complement(12035..12349)
                     /codon_start=1
                     /db_xref="InterPro:IPR005153"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1009: mbtH-like protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="protein motif:PFAM:PF03621"
                     /locus_tag="Caci_2721"
                     /note="PFAM: MbtH domain protein; KEGG: cvi:CV_2232
                     MbtH-like protein"
                     /product="MbtH domain protein"
                     /protein_id="ACU71636.1"
                     /transl_table=11
                     /translation="MNVLDDEAAPFLVLGNAAQEYSLWPAAGDVPVPGGWRAVFGPAER
                     HACLAEIGRVWVDRAGAESAGGESSGTGSAGGESAGTESTGTESARAQSTAATGSGGPR
                     "
     gene            complement(12392..13615)
                     /locus_tag="Caci_2722"
     CDS             complement(12392..13615)
                     /codon_start=1
                     /db_xref="InterPro:IPR001128"
                     /db_xref="InterPro:IPR002397"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     aminocoumarin: novI"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic"
                     /inference="protein motif:PFAM:PF00067"
                     /locus_tag="Caci_2722"
                     /note="PFAM: cytochrome P450; KEGG: sgr:SGR_3267 putative
                     cytochrome P450"
                     /product="cytochrome P450"
                     /protein_id="ACU71637.1"
                     /sec_met_domain="novI (E-value: 2e-248, bitscore: 813.5,
                     seeds: 7, tool: rule-based-clusters)"
                     /sec_met_domain="p450 (E-value: 1.9e-15, bitscore: 46.3,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTPRPVVQPDDLDRVDLASPVLHAENNLDEVWRHLRANDPVHWHR
                     PVDGRPGFWVITRHADVHKVYQDKGHFTTAGGNALATLLTGGDSASGTMLAVTDGPRHQ
                     QIRNVMTRGLNPRTLEAVRHSLQQTVDRLLKNALDMGECDAAHDVAANVPLGAICDLLE
                     IPESDRHHLLGLTSHAWSTDHADEPPQEAWVAKSEILLYFSRLAKERRGAEYDDMVTLL
                     ANCRIKGEPLSATELMANCYGLMIGGDETGRHAITGTILALTENPDQWRALKNGDVDIK
                     TATEEALRWTVPSLHGGRTATGDVELGGKLIKAGDVASVWIYSANRDEEVFDEPDRFLL
                     GRTPNNHFTFAYGMHYCLGHYLGRMEVHAVLDGLRRLVGNVEQIGEEKWIYSSILHGMH
                     SMPVRMTA"
     gene            complement(13617..15392)
                     /locus_tag="Caci_2723"
     CDS             complement(13617..15392)
                     /NRPS_PKS="Domain: AMP-binding (9-406). E-value: 6.4e-104.
                     Score: 339.7. Matches aSDomain:
                     nrpspksdomains_Caci_2723_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (522-589). E-value: 2.5e-19. Score:
                     61.2. Matches aSDomain: nrpspksdomains_Caci_2723_PCP.1"
                     /codon_start=1
                     /db_xref="InterPro:IPR000873"
                     /db_xref="InterPro:IPR006163"
                     /db_xref="InterPro:IPR010071"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     aminocoumarin: novH"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic"
                     /inference="protein motif:TFAM:TIGR01733"
                     /locus_tag="Caci_2723"
                     /note="TIGRFAM: amino acid adenylation domain protein;
                     PFAM: AMP-dependent synthetase and ligase;
                     phosphopantetheine-binding; KEGG: bbt:BBta_4110 putative
                     non-ribosomal peptide synthase"
                     /product="amino acid adenylation domain protein"
                     /protein_id="ACU71638.1"
                     /sec_met_domain="novH (E-value: 0.0, bitscore: 1018.9,
                     seeds: 6, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 1.4e-11, bitscore:
                     34.7, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRRHLSQIWDDAALRHSRDTALIAGEETLSYGAVNERANRLARVL
                     IAGGAGPGRLVALALGRTVDMAVAVLAVAKTGAAFLPVDPEYPAERVAHMLRDAAPVLV
                     CATAATLGRLPADVPVPSLVLDSAPQLSALRAQAATDVTDEERRQPVSVTDLAYVIYTS
                     GSTGLPKGVAVTHTGLAGLAAAKIDTMRVGGDSRVLQFASPSFDAYLTEILAALTSGAA
                     LVIPPAGVLAGDVLRAVLRDHAVTHAVLPPTAAGTIAPEDVPDLRTLVVAGEALPAALV
                     ERWAPHVRMINAYGPTEGTVCATMTGPLAAGEPITIGTPMPGVSVYVLDDTLRPVPPGE
                     IGEVFIAGDGLARGYLGRPELTAQRFLADPFSSAGTRMYRTGDLASWPAGGGIVFHGRV
                     DEQVKLRGFRIELGEVESVLGRHPEVARAVAVVRSSSVAGAYGLAHHTAAQLLAYVVPA
                     DGGRPSSAALREHAARFLPEYMVPALFTTVDALPLTPNGKVDRAALPEPAAAPHMVGGG
                     PRTPAEKALCLIFGELLGFDEVGVGADFFALGGTSIVAIDVILRAQDFGLELTPRALID
                     NPTIEMLAAAAADGS"
     aSDomain        complement(13626..13826)
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_Caci_2723_PCP.1"
                     /evalue="2.50E-19"
                     /label="Caci_2723_PCP.1"
                     /locus_tag="Caci_2723"
                     /protein_end="589"
                     /protein_start="522"
                     /score="61.2"
                     /tool="antismash"
                     /translation="EKALCLIFGELLGFDEVGVGADFFALGGTSIVAIDVILRAQDFGL
                     ELTPRALIDNPTIEMLAAAAAD"
     aSModule        complement(13626..15365)
                     /complete
                     /domains="nrpspksdomains_Caci_2723_AMP-binding.1"
                     /domains="nrpspksdomains_Caci_2723_PCP.1"
                     /locus_tags="Caci_2723"
                     /monomer_pairings="Tyr -> Tyr"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       complement(14145..14210)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Caci_2723_0006"
                     /evalue="2.20E-11"
                     /label="NRPS-A_a8"
                     /locus_tag="Caci_2723"
                     /protein_end="416"
                     /protein_start="394"
                     /score="35.7"
                     /tool="antismash"
                     /translation="FHGRVDEQVKLRGFRIELGEVE"
     aSDomain        complement(14175..15365)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_Caci_2723_AMP-binding.1"
                     /evalue="6.40E-104"
                     /label="Caci_2723_AMP-binding.1"
                     /locus_tag="Caci_2723"
                     /protein_end="406"
                     /protein_start="9"
                     /score="339.7"
                     /specificity="substrate consensus: Tyr"
                     /tool="antismash"
                     /translation="DDAALRHSRDTALIAGEETLSYGAVNERANRLARVLIAGGAGPGR
                     LVALALGRTVDMAVAVLAVAKTGAAFLPVDPEYPAERVAHMLRDAAPVLVCATAATLGR
                     LPADVPVPSLVLDSAPQLSALRAQAATDVTDEERRQPVSVTDLAYVIYTSGSTGLPKGV
                     AVTHTGLAGLAAAKIDTMRVGGDSRVLQFASPSFDAYLTEILAALTSGAALVIPPAGVL
                     AGDVLRAVLRDHAVTHAVLPPTAAGTIAPEDVPDLRTLVVAGEALPAALVERWAPHVRM
                     INAYGPTEGTVCATMTGPLAAGEPITIGTPMPGVSVYVLDDTLRPVPPGEIGEVFIAGD
                     GLARGYLGRPELTAQRFLADPFSSAGTRMYRTGDLASWPAGGGIVFHGRVDEQVKLR"
     CDS_motif       complement(14211..14243)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Caci_2723_0005"
                     /evalue="5.20E+01"
                     /label="NRPS-A_a2"
                     /locus_tag="Caci_2723"
                     /protein_end="394"
                     /protein_start="383"
                     /score="-1.5"
                     /tool="antismash"
                     /translation="LASWPAGGGIV"
     CDS_motif       complement(14295..14384)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Caci_2723_0004"
                     /evalue="7.10E-17"
                     /label="NRPS-A_a6"
                     /locus_tag="Caci_2723"
                     /protein_end="366"
                     /protein_start="336"
                     /score="53.5"
                     /tool="antismash"
                     /translation="PPGEIGEVFIAGDGLARGYLGRPELTAQRF"
     CDS_motif       complement(14721..14753)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Caci_2723_0003"
                     /evalue="8.40E+00"
                     /label="NRPS-A_a2"
                     /locus_tag="Caci_2723"
                     /protein_end="224"
                     /protein_start="213"
                     /score="0.9"
                     /tool="antismash"
                     /translation="LAALTSGAALV"
     CDS_motif       complement(14865..14924)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Caci_2723_0002"
                     /evalue="1.80E-10"
                     /label="NRPS-A_a3"
                     /locus_tag="Caci_2723"
                     /protein_end="176"
                     /protein_start="156"
                     /score="32.6"
                     /tool="antismash"
                     /translation="AYVIYTSGSTGLPKGVAVTH"
     CDS_motif       complement(15141..15182)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Caci_2723_0001"
                     /evalue="5.90E-04"
                     /label="NRPS-A_a2"
                     /locus_tag="Caci_2723"
                     /protein_end="84"
                     /protein_start="70"
                     /score="13.3"
                     /tool="antismash"
                     /translation="LAVAKTGAAFLPVD"
     gene            15558..17078
                     /locus_tag="Caci_2724"
     CDS             15558..17078
                     /codon_start=1
                     /db_xref="InterPro:IPR002938"
                     /db_xref="InterPro:IPR003042"
                     /db_xref="InterPro:IPR006076"
                     /db_xref="InterPro:IPR006905"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Trp_halogenase"
                     /gene_functions="biosynthetic-additional (halogenases)
                     flavin-dependent cycline orsellinic halogenase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1119: halogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="protein motif:PFAM:PF04820"
                     /locus_tag="Caci_2724"
                     /note="PFAM: tryptophan halogenase; monooxygenase FAD-
                     binding; FAD dependent oxidoreductase; KEGG: fal:FRAAL4634
                     putative halogenase"
                     /product="tryptophan halogenase"
                     /protein_id="ACU71639.1"
                     /sec_met_domain="Trp_halogenase (E-value: 7.4e-29,
                     bitscore: 90.7, seeds: 23, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRSDRRILTKRMVFSEMTEVIVVGGGPAGSTAAALLAKNGVSVT
                     LLEREAFPRYHVGESITYSCRGVLDYIGALEKIEARGYTRKTGVLLRWGQELDWAIDWT
                     AQFGPDVRSWQVDREDFDQVLLQHAAECGAQVLEQAQVKRVVFEDGRAVGVEWTPQGHS
                     EPQITRADLVLDASGRAGLISAQHFRDRRATEIFRNVAIWGYWDGGELLPDSPSGSINV
                     ISSPEGWYWVIPLSGNRFSVGYVTHKSVFVERRKDYDTLDDMLAAVVAESPTVSEAMAK
                     GTVRPGARVEQDFSYAADSFCGPGHFLVGDAACFLDPLLSTGVHLAIYSGLLAAASVLS
                     IENGDVTETEAYAFYESRYRNSYERLFTLVAGFYQKHAGKDRYFELAKALTREHKGLEG
                     SADLAFGEITSGITDLREAKDDSGLGDRPIRESVAEAASRRSKVQDLLSATEQAQQRAE
                     AGLPNTGGDRGRSRVQIDADDLYDAATGLHLVMEPRLGIQRAAVPAAG"
     gene            complement(17159..18454)
                     /locus_tag="Caci_2725"
     CDS             complement(17159..18454)
                     /codon_start=1
                     /db_xref="InterPro:IPR000792"
                     /gene_functions="regulatory (smcogs) SMCOG1149: LuxR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="protein motif:PFAM:PF00196"
                     /locus_tag="Caci_2725"
                     /note="PFAM: regulatory protein LuxR; SMART: regulatory
                     protein LuxR; KEGG: saq:Sare_1270 LuxR family
                     transcriptional regulator"
                     /product="transcriptional regulator, LuxR family"
                     /protein_id="ACU71640.1"
                     /transl_table=11
                     /translation="MRGIIIRNDDLRSVRAPVCGVTDRLTRSRRSWLAGRLESGIGHAD
                     AAFRTDCTECAEPCSQYAGLWLAMLLSQIRRVDRAVRALDAVDISAAARGDRPLATAAT
                     LVRAKVEAAAGRFDTATALAAAGLREAEEVGLKSWTPLGNFVIALTAVRQGDLATALRY
                     AQRMEEDAVFGRKMLPPGQAAWAILQIAEAEQGWEKVAARAAELLDSGHVIRQLLISEP
                     AAAPWLVRLMLKSGERALAQEGVWASRRLAAVNPGVRSTAAAALHAVALYEADMEKLAS
                     AAELHVDQWARASAVEDVGAVLTDRKGDRGRAALILEDARGAYAQIGALRDAARVKSRL
                     RGINTIVPAQDQGLPASGVAGLTRTEYAIAKLVAGGLTNGQAAEQLYLSRHTVAFHLRK
                     IFRKLGVASRVQLARLWAELDSGGGLEPGAAG"
     misc_feature    complement(18008..18010)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(18723..20225)
                     /locus_tag="Caci_2726"
     CDS             complement(18723..20225)
                     /codon_start=1
                     /db_xref="InterPro:IPR001411"
                     /db_xref="InterPro:IPR004638"
                     /db_xref="InterPro:IPR007114"
                     /db_xref="InterPro:IPR011701"
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="protein motif:TFAM:TIGR00711"
                     /locus_tag="Caci_2726"
                     /note="TIGRFAM: drug resistance transporter, EmrB/QacA
                     subfamily; PFAM: major facilitator superfamily MFS_1; KEGG:
                     sgr:SGR_1339 major facilitator superfamily permease"
                     /product="drug resistance transporter, EmrB/QacA subfamily"
                     /protein_id="ACU71641.1"
                     /transl_table=11
                     /translation="MTQSYERAAPPDDGPADPNRWRALTVCLVAGFMTLLDVSIVNVGL
                     PQMEAGLRASPADVSWVRAGYTLTFGLVLVPSGKLGDALGRKRVFLLGLFLFTGVSLMC
                     ALSPTAQWLVVARLLQGVAGGLLNPQIIAMIQQLFRGSERGKAFGLYGGTVAVATAIGP
                     LAGGLLIEAGGWRWMFLINLPIGVVGLVLGVLLVPKIPPRRRGRGMDLVGVALLGGGIT
                     SIMLPLIEQEQGGAAVHWWLLGLAAVLLVAFVFWERWWKGRGLDPLVNLSLLRTPSFGA
                     SSLVGLAYFAGYPGVLFILSLYLQQGRAYSALAAGATSMPFAVGSAISAAVSGRAVYRI
                     GRVLVVAGLVAVLAGLIPAAVIIQHDTGGAVWARLFLPLLVAGLGSGLVIGPNQTLALQ
                     FVPPASSGTAAAMVQTGQRIGMSVGTAMAATMFFGHLKVLRHDYSGAASRSLYGAAALV
                     TVALAAASVDLAAARRLRRRPATGQAAEVPGSRTGSAVVKRS"
     gene            20282..21076
                     /locus_tag="Caci_2727"
     CDS             20282..21076
                     /codon_start=1
                     /db_xref="InterPro:IPR001647"
                     /db_xref="InterPro:IPR004111"
                     /gene_functions="regulatory (smcogs) SMCOG1239: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="protein motif:PFAM:PF02909"
                     /locus_tag="Caci_2727"
                     /note="PFAM: Tetracyclin repressor domain protein;
                     regulatory protein TetR; KEGG: sco:SCO7624 TetR family
                     transcriptional regulator"
                     /product="transcriptional regulator, TetR family"
                     /protein_id="ACU71642.1"
                     /transl_table=11
                     /translation="MSTENVDETAATRSIWERMALSPPVHRPVLTHALIAEAALRIADA
                     DGLEAVSMRRLATELGVSSMTCYRYVSGKDDVIELMLDTVRGGMLLDEDELAEPGEPGE
                     SAGRAEPAGSSHWRRVLRASAMRFRGVILMHPWMTDLPGRILFAPTPAFLAVAEQNLAA
                     FDGLGLTAAQITDITGAVTAYTRAGTHDEVTRERLRAPEGWTSPRDAKDANTDRLAWLL
                     ANGDYPRYERSLHEGAPRHDEQARFEFGLDCLLDGIAARLSR"
     sig_peptide     21837..21944
                     /locus_tag="Caci_2728"
                     /note="Signal predicted by SignalP 3.0 HMM (Signal peptide
                     probability 1.000) with cleavage site probability 0.953 at
                     residue 36"
     gene            21837..23336
                     /locus_tag="Caci_2728"
     sig_peptide     23443..23541
                     /locus_tag="Caci_2729"
                     /note="Signal predicted by SignalP 3.0 HMM (Signal peptide
                     probability 1.000) with cleavage site probability 0.964 at
                     residue 33"
     gene            23443..24882
                     /locus_tag="Caci_2729"
     gene            25199..25336
                     /locus_tag="Caci_2730"
                     /pseudo=""
ORIGIN
        1 gcagttcgag gggcagcgtg ggatccaccc ggacggcgtt gcgggccggg accatcgcgt
       61 actcggcgaa cgaggactgg ccgaaccatc gcggcgccaa agggattccg gccgcgtcgg
      121 cgaatcgcgc ggcgttcgtc gtgcgcccgc cgaacaggtt gagctcggcg aaggaatcac
      181 agtaggcggg ggcgccgctg atacaggccc ggcagtgtcc gcaggagtcg aaactcagca
      241 cgacgtggtc cccgacggcc agccgggtgt ccggaccgcc ggtctccacg acgaccccgg
      301 agccctcgtg gccgaggacg gccggcagcg gcgagcggcc cgccgaaccc cggacggcga
      361 gatcggtccg gcacatcccg catccggcga ttctgaccag gacctcgtcc ggtgccggtc
      421 cctcctccaa agccacctgc tcgacggcga atcggccctc gtacgaacgc agtaccgccg
      481 cgtcgaaccg gatggccacg tcacgtctcc tcgggccggt gcacgacgaa cggtcggagg
      541 ttcccgtaga agccccacgg cccgcccgcg acacctacgc cgctgtcctt cgcgcccgcg
      601 aacggctggg caagggagag ctcgccgtgg tggttgatcc agacggtccc gcattcgagc
      661 cgttcggcga cctcctcggc ccggtccaga tcggttcccc acaccgaacc gccgaggccg
      721 aaaccggtgg cgttggccgc ttcgacggcc tgctccacgc cgcggtacac gagcaccggc
      781 agcaccgggc cgaactgctc ctgagcgacc accgggctct gggccgagac gtcggccagg
      841 atcgtcggcg cgaagaagta gcccggcctg tcgagccggt gcccgccggc cgcggcgcgg
      901 gcgccggtcg ccaaagcctc cgccgcgtag ccctcgaccc gggcgagctg aggggcgttg
      961 ttgaccggtc ccagttgcga tcccgcttgc aggcccggtc ccacgacggt ctgatccgcg
     1021 cgctgtgcca gggcttcgac gacttcggca tagagccggg ccggggcgta gacccgcttg
     1081 accgccatgc agatctgccc gcagttgcgg aacgccgccc agaacagccg gtccacgatc
     1141 tgctccacgt ccacgtcgtc gagcaggatc gcggcatcgt tgccgcccaa ctccagggtg
     1201 acccgggcca gcgaggacgc cgcgccccgg gccacggcgc ggccggtggg aaccgagccg
     1261 gtgaaggtga cgtgcccgaa ccccgggtgg gaggcgaggc gctcgccgag gggttcgcgg
     1321 ccggtgacga tcgtgaggac gtcctcgggc agggcggcgg ccagcaccga tcccagcatc
     1381 ctggtggcca ggggagtgaa gggggagggt ttgagcacca ccgtgttgcc cgcggcgagc
     1441 gcgggggcga acttcgcgga ggcgagttgg agcgggaagt tccacggaac gatcgcggcg
     1501 acgggaccga gcggccgcca gcggacctcg ctgcgcaccg gtcggccgtc cacgatcggc
     1561 cgggtctgcg ggcgaagcgt ggcgaagtag cgaaggcggg ccgctgcgcg ggccacctcc
     1621 gcgaacgact ccggcagcgg tttgccctgc tcgcgggtga gcagcggggc gaggtccggc
     1681 ccggcccgct ccaccgcgtc ggccgccgcg agcagcgcgg cggcgcgggc gtcggggtcg
     1741 gcacgccacc cgcgccaggc cgtgtgcgcc cgctcgacga tcgcgtccag ttcctcaggc
     1801 tgctgatcgg gcgcctcggc aaagggctcg ccggtcgcgg gatcgaggac tgcgaagctg
     1861 ccgccgcggg cccggtgcgg gcggctgggc tcagtcgtcg gcatgccggc gggtcagttc
     1921 ccggcgggga cggcggcctg ttcccggctg tgccggtcca tctcggctcg gaaggccgcc
     1981 accagatgcg gttggatccg tccggtggtg cggtcgccgc gctcgcacac cgccccgcgc
     2041 acccccacga tgtccgtgcc gatggcggtg agcgtgccca ggtcctccgc tctgacgctg
     2101 cccgcgagcg ccgcgagccg cccggtgtcg tgcgcccgcc ggacgaactc cgcgcacagg
     2161 tcgggcggaa cgtggtcgaa cagccgggtc ccgtccttga tggcggtgtc gagcatggcc
     2221 gcgtcgcagc cggagcggcc ggcgatgtcg ggcacggcga gcgggttgac gcagccgacg
     2281 cggtgggcgt cggcgtaccc ggaggcgacg acgagcgcgt ccggccggta gtccttgacc
     2341 gctcgcacga cggcgcgcat gacggtgacg gcctggtcgg gcgtggtgca gccgaacagg
     2401 ccgaccttga tgtacgtggc gcccgagaca accgcgccga gtgccgcctg ggcgaccgtg
     2461 ccgggtttgt agggcacgtc ccccacggtc gccgataccg gcttgtccgc cgggacgatg
     2521 tcgcggatct cccggatcac ccacgggaag ttggcaccga gcgagccctc gtccggcttc
     2581 ttgacgtcga cgatgtcgag gtgccgcgac gccttcgcgc agtcgcgggc ttcttcgacg
     2641 tcggccgggg atatgagcag caacaacgcg ttctccgttc cgaggatgct cagccaggac
     2701 gctcagcgct gttgcgcggg gatcaggtgg ttgccccggg tgtcgccgtc gcccgggtcg
     2761 tagaactcca cgatcgcgac ccgccacacc tccgcctcga tctggtcctg cgcggtggga
     2821 ccgaaggaat cgaagagcgc gttcaggttc tcgcgcccga agccgatcgc cgtcatcagc
     2881 gcctcgaaga ccgggcggtc gatgagcccg tcgccgtcgg ggtcgccgag cgcggacagc
     2941 gcctcggcga actgctcgac ggccgcgccg aagcgctccg gactgaggac gaaagcctgg
     3001 aactcctcgg cgctgatccg tccgtcgtgg ttcgcgtcga gcgcgtcggc catcgtgatc
     3061 cagtagcggt cgaaggcggc gcgcatcgcg tccttcgcgg cctggtccga gccggtcgcg
     3121 gcggcgacca cccggttcgt catgagcgcg atgtccgcgg cctcgatgaa gccgttgccg
     3181 tcggtgtcga agaggtcgaa gacgtgctcg acccgcttgg cggcctgggg gtgggggttc
     3241 atggggactt cggcctcccg atccttggtg acctgcttgt ccgattgtcg gttcgaagac
     3301 cggattgcgg accctatgag ggccctgatt cactcgatcg tggaacctcg cgcggaacgt
     3361 gcctccgtgt ggcgccggcg cgccctgccg atgaaggtcc tgtcaggacg atgtgttcga
     3421 tgagccgatg ctcgtggtga cggcgcactg cccggtccgc ggcgggcagc tcagactcgc
     3481 gccgcccacg acgtgcagca gcagcggtgc gtcgccggcg ccggctgtgt ccagagcccg
     3541 gcgcaggcct tggggatcgg gggcgggcgg ctggcccagg acggtgatgt cgaccctgcc
     3601 gtcgcgggcc gtgaccgatt cgacctccca gccgtgcccg gcggcccagg cccgagccgc
     3661 cgggccggcg tccgcggcca gttgccggtc ccgggtcacc gccacggtgc cgatcgtcag
     3721 cggcacggcc accagtacca gcagtgccgc gacgctcgcc aggctggtgc cgcgcaggcg
     3781 ccccacgcgc cggccggcgg cctgggccgc ggcacggact tggaagatga ggaagacggt
     3841 gatgccggtg ccgatgatgg cggcgacgtt ggtgctgaac agcagggcgg cctggccggc
     3901 gtcgtggaag cggcggactt ccagcagcag cccggtcacg gccagcggcg gcaccaggga
     3961 gatggcgatc gccacgccgg gcagcgcgtc ggagacgtcg gcccgggcca gcgcgaacgc
     4021 cccggccgtg ccggtggcca gggcggcgag caggtcgatc aggtgcgggc tgatccgcga
     4081 ggcgacctgg ctgttgccgg cgaagtcgtc cggcggcgcc ccgatccagc cgaccaggta
     4141 ccccacggcg atcaccgagg cggaccccgc gaccaccagc agcaccgagc ggatcagatg
     4201 cctgcgatcg accaggacga acgccagcgc gctgcccaga atcggggtca tcagcggagc
     4261 cacgatcatc gccccgatga ccgtggcggt ggagtcgccg accaccccgg ccgaggcgat
     4321 cagcgcggcc aggatcagca gcgtccagaa cttgctcaag ccccgcgagc gccaccccgg
     4381 ctcgatgaac agcgacgccg tcatccgctc gacatccgcc ccggtgatct caggcatctg
     4441 cgcccggccc tggaccggtg gcgtgagtca gcactcttgg aatctaccga cgtcgacgac
     4501 ccctgtcggc ccgggctacg ccgttcgagc cggaccggag ggcgagggcg cgtctcggtc
     4561 aggccgtgaa cccgggcgcc acggcgcggg ggtcgccggg gacgcggccg aggtcaggcg
     4621 gtgcaggacc ggggtggtga cggcggtcgt cgccaccgcc atcaacagca gcgcggtgaa
     4681 caggtgggcg tcgatgatgc cgatcgacag gccgatgtcg agaacgacga tctcggtcag
     4741 tccgcgcgtg ttcatcagga ctccgaggat cagcgcctcg cgccggtccg tgccgcagat
     4801 gcgggccgcg gccgccactg ctccgatctt cgccgtcgag gccagggcca cgacgccgaa
     4861 gccgagctcg aagccggccc agcccagggt gtggaagtcc gcgctcaggc cggtggcgac
     4921 gaagtacacc ggcatcagga tcgcgccggt gcgctccagc ggctcggcga tgtcgagcat
     4981 gaggacggcg cgggagtccc gcggcatcac caggccgagc aggaacgccc cgaaggcggc
     5041 gtgcaatccc gccgccgagg acacgtacga cgatgccagc accgcggcca cgaccagcgg
     5101 cagcgtcccg cccgagccga ccgcgcggac gtgcgccagc gccgtgcgaa gcagcggccg
     5161 gacgatcagg aacatcgccg ccaggtagac aacgaccagc gggagcgtcg tccatgatgc
     5221 cgccgagccg gtcgccgacg ccgcgatgac cacgagcgcc agcccgagcc agccgcacag
     5281 gtccgtgccg gccgccatcg ccatcgcggt ctgcccgacc ggcgtgttcc gcagcggact
     5341 gtcaccgagg atccgggcca ggaccgggaa ggcggtgatc gccaacgcga cgccgatgta
     5401 gaccacgaac accgcttccg tgacgcggtg gcccgaccgg gttccggcat aggccggata
     5461 cagcgcgaag gcgagcgcgg cgccgaccgc gaacggcacg acgaagttcg cggccgtcat
     5521 cgcgatcgtc gccgtgcgcc gcgcccgcac gaccgagacg tccagctccc acccgatggc
     5581 gaacatgaac agcagcaggc ccagctcggc cacggaggtc agggtgccgc ggccggacgc
     5641 cgggaacagc cggccggtgg ggtcgcccgg cagcaggccg agcaggctcg gcccgagggc
     5701 gactccggcc aggatctcca cgacgaccgc cgactggcgc agcggccggg cggccgtgcg
     5761 cgccgcccag gccgcgacga tcgccaccgc gacctctccg gcaagaaccg cgtccggcgc
     5821 gaccgcgaac gccatgggtc atcacccccg cttccggtcg ccgacgagcc cttcttcgac
     5881 tggcgccttc tctgctgacc ccttctccgc tgagcccttg tcggccggcg ccacgtcctc
     5941 gagccgtgcc gcggcgaagc ggccgggccg gaagtccgcg agcgccgcag cctccttcga
     6001 ccccagcacc tcgccggcga ccagccgcgc gagatactgc gcgagcgtga tcccgctgtg
     6061 cgtcacgacg acatacagtc ccggcacgct ctcggtgaag cccgccaccg tgagcccgtc
     6121 ggccggcatc ggccggacgc cgacgcgcac cgcgtcgagc gtcacctccg ccatcgccgg
     6181 gaacagcctc cgggcccgct ccagcagccg cggcccgttc tcgaacaccg cggggtcgtt
     6241 tcgcgggacg cgcgacccgg cgccgtcgcc gccgaggacc gcccggccgt aggccgaggg
     6301 gcgcaggccc atgtccgggg tgtgcacgat gcggcgcagc gggctgcgca gcggggcggt
     6361 gaacgcgagg ccgccgacgg cggtgtagcg ctcgtcgggg gacccctcac ggccctcgcc
     6421 gccggacgcg cgcggcttgc gcgccgtctc ggagatcatc ggcaccgcga tgccggagcc
     6481 cgcgagcagc gcttcggtgg ccgtgccggt cgcgcacacc acatagtcgg cgagcagttc
     6541 ctcgccgtcg gccagcagca ccttcgtccc ggcgccggcc ggctcgaacc cgacgacggc
     6601 gtggtgcgtc cggatcacgc cggtaccggc ccggacgtcg gccagcgcgt cggagaccat
     6661 ctcctcggcg tcgacccagc cctcgtccgg gaaataggcg gcggccgcga tccggtcggg
     6721 gtcgatgagc ggttcgaggt cggccgcccg ccgcgcggac acgttctcgg ccgcgtagcc
     6781 gcgcgcggcg aggtccgcga cgttggcctc cagcgcctcc gccgaggccg cgtccacggc
     6841 gacctccaca ttgccgaccg cgtggaacca gccgctcccg acccccgccc gggccagccg
     6901 gtggtactcg gccaggccct cggcgttgag ccggaagtag gactcgggcc gcttcttctg
     6961 cgcgttcgcc caggcgaagc tggtcgagct ggtgccggag ccgggcaccg cggcgtccag
     7021 cagggtgacg cgggccgagc gggccgcgca cgctccggcg atgcaggtgc cgaggacgcc
     7081 gccgccgacg accaccacac ggggccggtt cctcatgcgt gggtcctccc gatcgtcgcg
     7141 acctgcgcgg ccgggcggtc cgcgccggtc aggttcacca gcaccacgga gtccggcgcc
     7201 agcagcccgg cctctgccgc ctccagcact ccggcgaacg ccgtcgagct ggcgaagcag
     7261 acgtcgacgc cgacggtctc ggcgagcacg cgccgcgcgt gccggatccg ctcctcgccg
     7321 gcggccagga tccggccgcc gctggtcaga cacaggtccc tgatgtacgg gtaggtcccg
     7381 gtcgggtcgc cgcgcaggat cgcgtaggcc aggcccttgg ggtcgcgcac gacgtggcgc
     7441 ggcgcgatct ggtcggcgtc ctcggcgaag gcctgcgcca tcggcgagca gctggcttgc
     7501 tggacggcca tgaacgaggg caccttgccc agccgcccga gctcgcggta ctccaccgcg
     7561 cccttgtagg cgccgaccag gcccatgccg ctgctgacgg cctggaacac gtagtccggc
     7621 tcggcctgca tctcgtcgta ggcctccagg taggccagtt tgaggccctc gcggcggccg
     7681 aggttgaaga acccgccctc ccagaagaag ccgttgtcct gggcgaagcg ctcgccgacg
     7741 cggccggcgg tgacgaactc gccgtccacg acgtgggtca cgatgcgcgg atggtcggcg
     7801 tagttgaggc ggctgacgaa ctcgcggccg acgaagatgt gcagggtgaa gccggggacc
     7861 agcgagacgg cgcgcgcgta ggcggtggag ctgttgccgg tggaggacag cacgaggtcg
     7921 cggacgccca gctcgccgaa gcgggacagg cacaccgagg cgacgcggtc cttcgtcgag
     7981 gacgtcgggt tcacggcctc gttcttgaag tagagctggg ctatgcccag cgccgaggcc
     8041 agctccggga cctggaagca cggggtgttt ccctccccgc cccagtgcag cgacgagcgc
     8101 tcgcggaccg ggagcagcga gaagtagtgc tgaagggggt cagggccctg cttctcggcc
     8161 gggatctgta cctggtcgag gtcgtagatg gcgtcgatgg cgccgccgca ctcggtgcat
     8221 ttgttgaagg ccggttcgat gaactcgtgc tcacagcgca cgcagaagta tctgatgacc
     8281 ttggcgctgc cggcttctcc ggcgctgttg gtgtcgccgg cgccgctggt gccgtccccg
     8341 gccgagccgc ggaccttccg gatcaggctt tcgtagtttc cgatgaattc ggccacgccg
     8401 gttcatccct tcccgcctcg gggtgcgagc tctgctcgcg gaccaggacc cgatcgacct
     8461 tgccgttgac gttgatcggg aatgcgcgcc accgcgtgag ggtggccgga acgtgggtgg
     8521 gggtcatcag ggccgcgacg tgcccgcgca gcgcctcgcg cgccggcggg tcgtcctcgc
     8581 gcagcacgac ggcggcgtgc agctcgccga gcaggtccgg accctgccgt ccccagacac
     8641 aggcgtcggc gacgccgggg tgcccggcca ggaccttctc gacctcgatc gggtggacgc
     8701 gggtgtcgtg caccttgacg acgtcgtcca tccggccgaa cagccgcagg tagccgttgt
     8761 cgccgatccg cccgaggtcg ccggtgtgca cccagccgtc gcggagcacc cgggcggtca
     8821 ggtcgggatc ggcggcgtag ccgagcatgt tgttggcacc gcgcaccacg acctcgccga
     8881 gctgcccggc cggcaggccg cggccggtcc gcggatcgcg gacggccacc gtcaggtcgg
     8941 tccgcgggcg tccgacggtg tcgagcagct cggcgacgtc gtggtcggcg gcggtgagca
     9001 tggcgatctg gccggtctcg gtggtgccgt aggagtggtg caggacgccg gggaagacct
     9061 tgacggcttc gcggacacgc tccggcgagg ccgcgcagcc gatgtagagc aggcggcgca
     9121 gcgaggacag gtcggtggtc ggagcgtccg ggtggttcgt gagctgatac aggagcggga
     9181 cgccgatcag ggtgtcggtg acgcggtatt cggcgatgtc gcgcaggaag gcggcgggtt
     9241 cgaaggctgt gcggagcagt gcgctgccgc cggaggcgat cgccatgtcg gtgagcaggc
     9301 cgccggtgtg gctgacggcg ctgaccgcga ggaaggtctt cgcggacgtg aaggtggcct
     9361 cgttgaggac gacgttgttc caggcgacga agggtttgac cacgcctttg gggctgccgg
     9421 tgctgccgct ggtgtagatg accatggcgc gggtgggggt gtggggggtc aggtcgatgg
     9481 tgctggcggc gctgccggtg gcggtggtgg tggtcggctc ggcgaccggg ctgccgtcga
     9541 tggatacggg ccctgacagg ggtgtcccga gcgcgcagag gcggacttcg gatcgggagg
     9601 cgaggagcgc gcggatgccg tcggcctcgg cggcgttgtc ctcgtcgaac agcaggaccg
     9661 acgcgccggt ctcgtgcacc atgcgggcgc gggtctggcg ggtgaggccg tgggtggtcg
     9721 tcccgtggtt cgagccgctg acgtagacga cggtcgcgcc gacgaggtgg acggcgtagc
     9781 gggtggccag catccaaggg ctgttcacgg aggtcaggac ggcgacggtg tcgtcgctgc
     9841 cgacgtccag ccggcgcagc gcggtggcca cccgtatcag ggcgctgcgc agctcggcgg
     9901 ccgggacgac ggtgtcctgc cagcggatca ccggccggtc gtcgtcgagc gcgagctggt
     9961 cgaggatgcg ggcgacgtag tggcccgggt ctttcatggt ctactcccat ctggcggacg
    10021 gcgccgccgg gcggccggcg aggtagccgc cctgcccggt gatcgccgag gcctgatcgc
    10081 tgatcaggaa tccggtcagg gccgccacgc cggcggcata gctcgggccg gtgccgccgc
    10141 cgccggcggc cgcggcgggc ggcggcgcgg gcgcgtgggc cggaccggcg ggatagcagc
    10201 tgctcggcgc gatgtagttc gcggtgacgc cgtacgcggc caactccagc gccgcggagc
    10261 gggtgaaacc gacgagcccg ccgagcacgg tctgcccgtc gcgccactcg cggtccgccg
    10321 ccccgtcggc caccgccggc tgcgcgatat tgacgatccg gccccaccgg ttgcgcacca
    10381 tgtgcgcgca gacggcacgg cagcaggcga acagcgcccg caggctgcgc cgcgcatcgg
    10441 cgtagcgctc ctcggcggac agcggctcgg gaccgccgag cggaacgcag ttcaccagaa
    10501 cactgggact gcccaggacc gagcgcgccc cgccgagcgc agcggcgaac gaccggccgt
    10561 cggcgaggtc ggcccggatg gcgaggcagt gccgcccgcc ggcgaagaac cgctccgtga
    10621 cctcgacggg cacggccacg tcggcgccga tcagagcgac atcgaggccg agctccgcga
    10681 gctggagcgc ggcagccagg ccggtatcgc acgccccgcc ggccacgacg gccatccggg
    10741 acagcgcgcc ggtctgcccg gcagccgcgg tcagcccggt caccgcgagc cgccttcgcc
    10801 gcacgccgcc ggcagtctgc gccgcgcgcc ggagatgctc gctttgccga ccgtgctcgc
    10861 gccgccgaac agggactcgc cggagaagct cgcgccgccg accgtgctcg cgccgccgat
    10921 cagggacttg ccgaagaggc tcgcttcagt ggccgaattc gcgccgccga acagggaccc
    10981 gccggaaacg ctcgcttcgc cagccgtgct cgcaccgccg accaggcgcc cgccgaacaa
    11041 gctcacttcg ccgaactcgc tcgcgccgct gaacctgctc gcgccgccga acctgctcgc
    11101 gccgccgaac ctgctcgcgc cgccgaacct gctcgcgccg ccggagaagc tcgcgccgcc
    11161 gaactcgctc gcgccgctga acctgctcgc gccgccgaac ctgctcgctt cgccgaacct
    11221 gctcgcgctg ccgaacctgc tcgcgccacc gcacagcacg ctccgccgac tcatcgccgg
    11281 cctccgtcga cggacacggt ctgcccggtc aggtagccgg agtcgcggcc ggtgaggaag
    11341 gccaccacgg cggcgatgtc gtcgaccgtt ccgacgcggc cgaccgccgc gtgggatgcc
    11401 gcctccttca ggaacgcctc gcggtccacg ccgaggcgat cggccagttc ggcgaccatc
    11461 ggggtcgcga cgaagccggg cgccaccgcg ttcacggtga tgccgtgcgg gccgagttcg
    11521 gaggccaggg cgcgggtgaa gccggcgagg gcggctttcg cggtcgcgta gttgctctgg
    11581 cccgggttgc cgtccgccgc gaccgagctg aaggtcacga tgcggcccgt gccgcggtgc
    11641 ttcatgagct cggcggccgc cagggaccag cgcatcgtgc cgcccaggct gacgtccagc
    11701 actgtgtccc actccgggtc gtccatggcc aggagcaggc ggtcgcgggt gacgccagcg
    11761 cagttcacca ggatgtcgag gcgcccgtag gccgccgcga tccgcagcat cgccgtccgc
    11821 acctcggccg cgaccgccac atcgcagccg atgccgagcg cccggccgcc cgcccggcgc
    11881 acggccgcga cggtcccggc cgtgtcccgc tcctcgcggt ccaccacgac gacggtcgcc
    11941 ccgcccgccg cgagccgcag cgccacggcc gcgccgatgc cccgggccgc cccggtgacg
    12001 accgcgacgg ttccggtgcc gtccggcgtc ctgctcatcg cgggccgccg gagccggtcg
    12061 cggcagtcga ctgtgcgcgg gctgactctg tgcccgtcga ctccgtgcca gccgactctc
    12121 cgccagccga ccctgtgcca gacgactctc cgccggcaga ctccgcgcct gcccggtcca
    12181 cccagacccg cccgatctcc gccaagcacg cgtgccgctc ggccggtccg aacaccgccc
    12241 gccagccgcc cggcaccggc acgtcgccgg ccgccggcca cagcgagtac tcctgcgccg
    12301 cgttccccag caccaagaac ggcgccgcct catcgtccaa aacgttcatg tcccactcac
    12361 tccgatccgc tggtcgaggc gatccgccgc gtcacgccgt catccgcacc ggcatcgagt
    12421 gcatgccgtg caggatgctg gagtagatcc acttctcctc gccgatctgc tcgacgttcc
    12481 cgaccaggcg ccgcagtccg tccagcaccg cgtgcacctc catgcggccg aggtagtggc
    12541 cgaggcagta gtgcatgccg taggcgaacg tgaagtggtt gttgggggtg cgcccgagca
    12601 ggaaccggtc cggctcgtcg aagacctctt cgtcgcggtt cgccgagtag atccagacgc
    12661 tcgccacgtc gccggccttg atcagcttcc cgcccagctc gacgtcgccg gtcgcggtgc
    12721 gcccgccgtg cagggagggc accgtccagc gcagcgcttc ctcggtcgcg gtcttgatgt
    12781 cgacgtcgcc gttcttcagc gcgcgccact ggtcggggtt ctcggtcagg gccaggatgg
    12841 tgccggtgat cgcgtggcgg ccggtctcgt cgccgccgat catcaggccg tagcagttcg
    12901 ccatcagctc ggtcgcgctg agcggctcgc ccttgatgcg gcagttcgcc agcagcgtca
    12961 ccatgtcgtc gtactcggcg ccgcggcgct ccttggccag cctgctgaaa tacagcagga
    13021 tctcgctctt ggcgacccag gcctcctgcg gcggctcgtc cgcgtggtcg gtgctccacg
    13081 cgtgcgaggt caggccgagc aggtggtggc ggtcggattc ggggatctcc agcaggtcgc
    13141 agatcgcccc gagcgggacg ttcgccgcca cgtcgtgggc cgcgtcgcac tcgcccatgt
    13201 cgagcgcgtt cttcagcagg cggtccacgg tctgctggag cgagtgccgg acggcctcca
    13261 gcgtgcgggg gttcagaccg cgggtcatga cgttgcggat ctgctggtgg cgcgggccgt
    13321 cggtgaccgc cagcatcgtg ccggacgccg agtcgccccc ggtgagcagg gtcgccagcg
    13381 cgttgccgcc ggcggtcgtg aagtggccct tgtcctggta gaccttgtgg acgtcggcgt
    13441 gccgggtgat cacccagaac ccggggcggc cgtccaccgg ccggtgccag tgcacggggt
    13501 cgttcgcgcg caggtggcgc cagacctcgt ccaggttgtt ctccgcgtgc aggaccggcg
    13561 aggccaggtc cacgcggtcg aggtcgtccg gttggacgac gggccggggt gtcatgtcag
    13621 ctcccgtccg ccgcggccgc ggcgagcatc tcgatggtgg ggttgtcgat cagggcgcgc
    13681 ggggtgagtt cgagcccgaa gtcctgggcc cgcaggatca cgtcgatcgc cacgatgctg
    13741 gtcccgccga gcgcgaagaa gtcggcgccg acgccgacct cgtcgaaccc gagcagctcg
    13801 ccgaagatca ggcacagcgc cttctccgcc ggcgtccggg gcccgccgcc gaccatgtgc
    13861 ggcgccgcgg ccggctccgg aagcgccgcg cggtcgacct tgccgttcgg cgtcagcggc
    13921 agggcgtcca cggtggtgaa cagcgcgggc accatgtact cgggcaggaa gcgcgccgcg
    13981 tgttcgcgca gcgccgcgga cgagggccgg ccgccgtcgg ccgggaccac gtaggcgagg
    14041 agctgcgccg cggtgtggtg cgcgaggccg taagcgcccg cgaccgacga ggagcgcacg
    14101 accgcgaccg cgcgtgccac ctccggatgc cggccgagga cggactccac ctctcccagc
    14161 tcgatccgga agccgcgcag cttgacctgc tcgtcgaccc ggccgtggaa gacgatgccg
    14221 ccgcccgcgg gccaggaggc gaggtcgccc gtccggtaca tgcgcgtgcc ggccgaggag
    14281 aacgggtcgg ccaggaaccg ctgcgcggtc agctccggac ggcccagata gccgcgggcc
    14341 agcccgtcgc cggcgatgaa cacctcgccg atctcgccgg gcgggaccgg ccgcagggtg
    14401 tcgtcgagca cgtacaccga caccccgggc atcggcgtgc cgatggtgat cggctcgccg
    14461 gcggccagcg gtccggtcat cgtggcgcag accgtgccct cggtcgggcc gtaggcgttg
    14521 atcatgcgga cgtgcggagc ccagcgctcg accagcgcgg ccggcagcgc ctcgccggcg
    14581 acgaccaggg tgcgcaggtc cgggacgtcc tcgggggcga tggtccccgc ggcggtcggg
    14641 ggcagcaccg cgtgggtgac ggcgtggtcc cgcagcaccg cgcgcagcac gtcgccggcc
    14701 aagaccccgg ccggcgggat gacgagcgcg gcgccggagg tcaaggccgc gaggatctct
    14761 gtgaggtacg cgtcgaagct cggcgaggcg aactgcagga cccggctgtc gccgccgacc
    14821 cgcatcgtgt cgatcttcgc cgcggccagg cccgcgagcc cggtgtgggt gacggccacg
    14881 cccttgggca ggccggtgga gccggaggtg tagatgacgt aggccaggtc ggtcacagag
    14941 accggctggc ggcgctcctc gtccgtgacg tcggtggcgg cttgggcccg cagggcactg
    15001 agctgcggcg ccgagtccag cacgaggctc gggaccggca cgtcggccgg cagccggccg
    15061 agggtcgcgg cggtcgcgca gaccagcacc ggagccgcgt cccgcagcat gtgcgcgacg
    15121 cgttcggccg ggtactcggg gtcgacgggc aggaaggcgg ctccggtctt cgccacggcg
    15181 agcaccgcca ccgccatgtc cacggtgcgg cccagcgcca gggcgaccag gcgcccggga
    15241 ccggcgccgc cggcgatcag cactctggcc aggcgattgg cgcgctcgtt caccgcgcca
    15301 taagaaagtg tttcttctcc cgcgataagt gcggtgtcgc gggaatgtct cagggcagcg
    15361 tcatcccata tctgggacag atggcgtcgc acggcattct cctctcacca gagtcaggac
    15421 tcggattttc gccaccgtat gccgccccgg agcccggccg ccatccccca ccttggtaga
    15481 gcgaagagcc cggaatagca ctaccaacat gggggatagt gcgcggcgcg cgacgggcct
    15541 agcgttcgga aaaagggatg tcgcgctctg acagaaggat cctgacaaaa aggatggtgt
    15601 tttcggagat gaccgaggta atcgtcgtcg gcggcggtcc ggccggatcg accgcagccg
    15661 ccctactggc caagaacgga gtttcggtca cgctcctgga acgcgaggcg ttcccccgct
    15721 accacgtcgg cgagtcgatc acgtactcgt gccggggcgt gctggactac atcggcgcgc
    15781 tggagaagat cgaagcccgc ggctacaccc gcaagaccgg cgtgctgctg cgctggggac
    15841 aggagctgga ctgggcgatc gactggaccg cgcagttcgg gccggacgtg cgctcctggc
    15901 aggtggaccg ggaggacttc gaccaggtgc tgctgcagca cgcggccgag tgcggcgccc
    15961 aggtcctgga gcaggcgcag gtcaagcggg tggtgttcga ggacggccgc gccgtcggcg
    16021 tcgagtggac gccccagggc cacagcgagc cgcagatcac ccgcgcggac ctggtcctcg
    16081 acgcctcggg ccgggccggt ctgatcagcg cccagcactt ccgcgaccgc cgcgccaccg
    16141 agatcttccg caacgtcgcg atctggggct actgggacgg cggcgagctg ctgccggaca
    16201 gtccgtccgg gagcatcaac gtcatctcct cgcccgaggg ctggtactgg gtcatcccgc
    16261 tgagcgggaa ccggttcagc gtcggctacg tcacgcacaa atcagtgttc gtcgagcggc
    16321 gcaaggacta cgacaccctg gacgacatgc tcgcggcggt ggttgccgag tcgccgacgg
    16381 tgagcgaggc gatggccaag ggcacggtcc gcccgggcgc ccgggtcgag caggacttct
    16441 cctacgcggc cgacagcttc tgcggcccgg gccacttcct ggtcggcgac gcggcctgct
    16501 tcctggaccc gctgctgtcc accggcgtgc acctggccat ctacagcgga ctgctcgcgg
    16561 ccgcctcggt gctctcgatc gagaacggcg acgtcaccga gaccgaggcc tacgcgttct
    16621 acgagtcccg ctaccgcaac tcctacgagc ggctgttcac gctggtcgcg ggcttctacc
    16681 agaagcacgc cggcaaggac cgctacttcg agctggccaa ggccctgacc cgggagcaca
    16741 aggggctgga gggcagcgcc gacctggcgt tcggcgagat cacctccggc atcaccgacc
    16801 tgcgcgaggc caaggacgac agcgggctcg gcgaccggcc gatccgcgag tccgtcgccg
    16861 aggcggcctc ccggcgctcg aaggtccagg acctgctcag cgcgaccgag caggcgcagc
    16921 agcgggccga ggccgggctg cccaacaccg gcggcgaccg cggccgctcg cgggtgcaga
    16981 tcgacgccga cgacctctac gacgccgcga ccgggctgca cctggtcatg gaaccgcggc
    17041 tggggatcca gcgggcggcg gtgccggcgg ccggctgacg gctgacggct gacggcgtga
    17101 gagcgccgca ccggcccggc ggaagccggc cggtgcggcg tcgatccgtg cgccgggctc
    17161 agccggccgc cccgggctcc aggccgccgc cggagtccag ctcggcccac agcctcgcga
    17221 gctggacgcg ggaggccacg ccgagcttgc ggaagatctt ccgcaggtgg aaggcgacgg
    17281 tgtgccggga cagatacaac tgttcggcgg cctgaccgtt ggtcaggccg ccggcgacga
    17341 gcttggcgat ggcgtactcg gtcctggtca gtccggcgac accgctcgcc ggcagtccct
    17401 ggtcctgggc cgggacgatg gtgttgatcc ccctgagcct gctcttgacg cgggccgcgt
    17461 cccgcagggc gccgatctgc gcgtaggcgc cgcgggcgtc ctccaggatc agcgccgccc
    17521 gcccccggtc tcctttccgg tcggtcagca ccgcgccgac gtcttcgacc gctgaggccc
    17581 gcgcccactg gtcgacgtgc agctccgcgg cggaggcgag cttctccatg tccgcctcgt
    17641 acagcgccac ggcgtgcagg gcggcggcgg ccgtggagcg gacgccgggg ttcaccgcgg
    17701 ccaggcggcg cgaggcccac acgccctcct gggccagagc gcgctcgccg gacttgagca
    17761 tcagccgcac cagccagggc gccgccgccg gttcggagat cagcagctgc cggatgacgt
    17821 ggccggagtc cagcagctcg gcggcccgcg ccgcgacctt ctcccagccc tgttcggcct
    17881 cggcgatctg caggattgcc caggccgcct gccccggggg cagcatcttg cggccgaaga
    17941 cggcgtcctc ctccatccgc tgcgcgtagc ggagcgccgt ggccaggtcg ccctgccgca
    18001 cggcggttaa cgcgatcacg aagttcccga gcggagtcca ggacttcagg ccgacctcct
    18061 ccgcctcccg caggccggcg gcggccagcg cggtcgcggt gtcgaaacgg cccgccgccg
    18121 cctcgacctt ggcgcggacc agcgtcgcgg cggtggccag cggccggtcg ccgcgcgcgg
    18181 ccgcggatat gtcgaccgcg tcgagggccc ggacggcccg gtcgacgcgg cggatctgag
    18241 acagcagcat ggccagccag agccctgcgt actggctgca tggttcggcg cactccgtgc
    18301 agtccgtgcg gaacgccgcg tcggcgtggc cgatcccact ctccagccgg ccggccagcc
    18361 aggacctgcg cgaccgcgtc aagcggtcgg tcaccccgca gaccggcgcc cggacggacc
    18421 gcagatcgtc gttcctgatg atgatgccgc gcattccgac actcgtactc atcgaagccc
    18481 ccatgatctc atcgcggctc cccctgccga aaaaccggcg tccgccgtgc cttcgggtcg
    18541 gaagggcggc ggacgcgcgg tgcctcggga cggggagaga gtaattgcac tcggaaagtc
    18601 gttgaaaacg tcaccatccc ccattgaatg gcgtttccat ctatgcccta ctatataagg
    18661 accctcaaat ataatcaagt tgttattcgt gcaagctcct cccaatcagg catccgggcc
    18721 ggtcaggatc ttttcaccac agccgaaccc gtccggctgc ccggcacctc cgcggcctgc
    18781 cccgtggccg gacgccgccg gagccgccgc gcggcggcca ggtcgacgga cgcggcggcc
    18841 agggcgaccg tgacaagcgc cgcggcgccg tacagacttc gggacgcggc gccgctgtag
    18901 tcgtgacgca ggaccttcag atgcccgaag aacatcgtgg cggccatggc ggtgcccacc
    18961 gacatgccga tgcgctgccc ggtctgcacc atcgcggccg cggtcccgct gctggccggc
    19021 ggcacgaact ggagcgccag cgtctggttc gggccgatga ccaggccgct gccgagcccg
    19081 gccaccagca gcgggaggaa caaccgcgcc cagaccgcgc cgccggtgtc gtgctggatg
    19141 atcacggccg ccgggatcag gccggccagg acggccacca ggccggccac cacgagcacc
    19201 cgtccgatgc ggtagacggc ccgcccgctg acggccgcgc tgatcgccga tcccaccgcg
    19261 aacggcatgc tcgtcgcgcc ggccgccagc gccgaatagg cgcgcccctg ttgcaggtac
    19321 agggacaaga tgaacagcac accgggatac ccggcgaagt aggccagccc gaccaggctg
    19381 ctcgcgccga acgacggcgt tcgcagcaga ctgagattga ccagcgggtc cagaccgcgc
    19441 cccttccacc agcgttccca gaacacgaag gcgaccagca gcaccgccgc caggcccagc
    19501 agccaccagt gcaccgccgc gccgccctgc tcctgctcga tgagcggcag catgatcgag
    19561 gtgatgccgc cgccgagcag cgccacgccg accaggtcca tcccccggcc gcgccgccgg
    19621 ggcgggatct tgggcaccag cagcacgccg agcaccaggc cgaccacgcc gatcggcagg
    19681 ttgatcagga acatccagcg ccagccgccg gcctcgatga gcagcccgcc ggccagcggg
    19741 ccgatcgccg tggccacggc gacggtgccg ccgtacaggc cgaaggcctt gccgcgctcg
    19801 ctgccccgga acagctgctg gatcatcgcg atgatctgcg ggttcagcag gccgccggcc
    19861 accccctgga gcaggcgggc gacgacgagc cactgggcgg tgggcgagag cgcgcacatc
    19921 aggctgaccc cggtgaacag gaagagcccg agcaggaaca cgcgtttgcg gccgagggcg
    19981 tcgccgagct tcccggaggg caccaggacc aggccgaacg tcagggtgta gccggcgcgc
    20041 acccaggaga cgtccgccgg ggaggcgcgc agcccggcct ccatctgcgg gaggccgacg
    20101 ttcacgatgc tgacgtcgag cagggtcatg aagccggcga ccaggcacac ggtcagggcg
    20161 cgccaacggt tcggatctgc gggcccgtca tcgggcggcg cggcgcgttc gtagctctgc
    20221 gtcatgattt acactgtaaa cgctctcgct tacgttgtaa atccgcgata acgttgtaca
    20281 catgagcacc gagaacgtcg acgagacagc ggccacccgc tcgatctggg agcggatggc
    20341 cctgtccccg ccggtccacc gcccggtgct gacccacgcc ctgatcgccg aggcggcgct
    20401 gcggatcgcc gacgccgacg gcctcgaggc ggtgtcgatg cgaaggctcg ccaccgagct
    20461 cggggtgtcg tcgatgacct gctaccgcta cgtctcaggc aaggacgacg tcatagagct
    20521 gatgctcgac acggtccgcg gcggcatgct cctcgatgag gacgaactcg ccgaaccggg
    20581 cgaacccggc gagtcggccg ggcgggctga gcctgccggc tccagccact ggcggcgcgt
    20641 cctgcgggcc tcggcgatgc gcttccgcgg cgtcatcctg atgcaccctt ggatgaccga
    20701 cctgcccggc cgcatcctgt tcgccccgac cccggccttc ctcgccgtcg ccgaacagaa
    20761 cctcgccgcc ttcgacggcc tcggcctgac cgcggcccag atcaccgaca tcaccggcgc
    20821 ggtcaccgcc tacacccgcg ccggcaccca cgacgaggtc acccgcgaac ggctgcgcgc
    20881 ccccgagggc tggacctcac cgcgggacgc caaggacgcg aacaccgacc gcctggcctg
    20941 gctgctcgcg aacggcgact acccccgcta cgagcgctcc ctgcacgagg gcgccccccg
    21001 ccacgacgag caggcccgct tcgaattcgg cctcgactgc ctcctcgacg gcatcgcagc
    21061 gcgcctctcg cgctgagccg gcgccgggcg accgcgaggt gtgaaccccg gcgtcagaac
    21121 cgttcgagtt cgagttcgat ctcgtgctcg ttgccgatca cggttcttcc atctgctctc
    21181 cctggggcgc ggtggcgatt ctcaaggcca tggcgttacg ggctgccgcc ctgccccgcg
    21241 attgccggac cgcggggcgg atgttaccgg taacattcag tgtcggaccg gtgccgtcga
    21301 cgatgggctc cggatgtgtc ttggcggtag acgctgcatc acacttcgag ctctgtcaag
    21361 gttccggatg cgagagcctc tacgcacctc tgggcttcgc atcgggggag tgcctgcgtg
    21421 gcttgcgcac gctgtgaaag ttcccatcga gccccccggc ctctcgatcc gctgacgggg
    21481 atgccagacc tgcaccgtcg gccaggatcg ccgtggatct acccggctgg catgatcagc
    21541 ccgctggaca tcgttatcgg aatgggctag aagacatccc atgtgtcggc cgtgatgccg
    21601 gtcccgctga cacgacgtca aaggcgttca tgagggttct catggtcgct cggcgatagc
    21661 gacggatcgc cattgtccat gcggcgtcgg ctttctcgcg gcgctgtcga aatccggtag
    21721 tcgacagctc ttctcggctc gggccagagc atcacgcagt cggattcctc gccagcggcg
    21781 cgccctccgt accggcgttc gtctgcacca gtccctgaaa gcgaagaagg tactccgtga
    21841 aactcagcca ctatcggtcc tggctgtcgg tcggcgccgc ggccacgatc gtggccgcgg
    21901 cgggagccgt cagcatgacg gccgcgccca cggctcaagc cgccggcgga tgccaggtgg
    21961 actacagcgt gtccagccag tggcagggcg gcttcggggc gaacgtcagc atcaccaacc
    22021 tcggcgtccc caccacggga tggaccctga cttggacatt cagcgccggt cagaccatca
    22081 cgcagctgtg gaacggcact gacacccaaa ccggcggcga cgtcgccgtg acgaacgcgc
    22141 cctacaacgg cgccatcccc accggcggaa gcaccagctt cggcttcaac ggctcgtggt
    22201 ccacgagcaa tccggcgccg gtcagcttcg cgctcaacgg gaccacctgt atcggttccg
    22261 gtccctcggg aacgccgacc accacgccgt cgtcaccgcc caccaccacg ccgtcgtcac
    22321 cgccgagttc caccccctca tcgacttcat cgacaccgtc cacgccgccg agttcctcct
    22381 cgaccaggct gccctgcgac atctacgccg ccggcggcac cccctgcgtc gcggcgcaca
    22441 gcacggttcg agctctgtac tccgcctacg ggggagccct gtaccaggta cggcgctcct
    22501 ccgacaacgc caccaaggac atcagcgtcc taacacccgg cggatacgcg aatgccgcga
    22561 ctcaggactc gttctgtgcc ggaacctcgt gtgtgatcac cgtcgtctac gaccagtccg
    22621 gccatggaaa cagcgtggcc taccaagggc cgggcggtgc gggaggcagc gacaccccgg
    22681 cgagcgccac acgcgaatcg ctgacggcag ccgggcacaa ggtgtacgac ctctacatca
    22741 acccgggtaa cagctactgg cacaacgggg cgtcctccgg catgcctgtc ggcagccagc
    22801 cgcagggcgc gtacatggtg accagcggcc tgcacgtcaa cagcggctgc tgtttcgact
    22861 acggcaacag cgagacggac cgccgagccg acggcgcggg cgcgatggac gccatcaact
    22921 tcagcacgag ttgctggttc ggcggatgca ccggcagcgg cccgtgggtt caagccgacc
    22981 tcgaatacgg cctgttcccc ggtggcagct cctcctggaa cccgaaccag cgcgcgttcg
    23041 ccgacaagta cgtcaccgcg atgttgaaga acaacggctc cacgcaaatg gcgctcaagg
    23101 gcggtagcgc acagacgggc agcttgacca cgctctggag cggcgccctg ccgcgcggat
    23161 acaacccgat gaagcagcag ggcgcgatca tcctcggcag cggcggtgac tgctgtgcga
    23221 gcaacaccaa cctgagtctc ggcaccttct acgagggcgc gatcgtcgcg gggtacccgt
    23281 cggacgccac cgacagcgcg gttcaggcca gcatcgtcgc ggccggatac cagtagcccc
    23341 gcgggcgacg ggctctcgga ccagggccgg tcgcagtcca cgttcaccat ggccgcgctg
    23401 aatcggccgc tcacaagtgt tagcgctaac aaaggagaca cgatgaacag atcccgatcg
    23461 cgtgccgtgc tcgccgtcgg tgcgtccgcc gcgctcgtcg gcgcgggcgt cgcgctgtcg
    23521 aacatgacgg cgcacgcagc cggcgccggt tgttcggtcg cgtactcgat cacctcgcag
    23581 tggggcggcg ggttcggagc gaacgtcagc gtgaccaacc tcggcgaccc ggtgtccagc
    23641 tggaccgtgg gctggtcgtt cggcgccggc cagcaggtgt cgcaggcctg gaacgcgacc
    23701 gtgacccaga gcggagcaca ggtcagcgcg gccagcatgt cctacaacgg ggtgctggcc
    23761 agtggcggct ccaccagctt cgggttcaac ggcacctgga acaacagcag caatccgatc
    23821 ccgaccgcgt tcaccatgaa cggcgtggcg tgcaccgggg gcgtgagcag ctccagttcc
    23881 ccgtccacgt ccccgtcgac gtccccgtcc agctcgacgt ccgtgccgcc gccgagccag
    23941 gagccctgcg acatctacgc cgcggcgaac accccgtgcg tcgccgcgca ctccacgacg
    24001 cgcgcgctct acggttccta caccgggaac ctgtaccaag tacgccggtc ctcggacaac
    24061 gccacggcga acatcggtgt cctgagcgcc ggcggaccgg ccaacgcggc ggcgcaggac
    24121 tcgttctgcg ccaacacgtc ctgcgtcatc acggtcatct acgaccagtc cggccggggg
    24181 aacaacctca cccaggcgcc cgcgggcggc gcggccggcg gtccggacaa cctggcgaac
    24241 gccacatccg cgccgacgac gctgaacggc cacaaggcct acggggtgta cgtcgcgacc
    24301 ggtaccggat accgggacaa cgccacccac ggcatcgcca ccggggacgc ctccgagggc
    24361 gagtacgcca tcttcgacgg cacgcactac aacggcggct gctgcttcga ctacggcaac
    24421 gccgagaccg acagccgcga tgacggcaac ggcaccatgg aggccatcta cttcggcaac
    24481 atccgggtct ggggctacgg ctccgggaac gggccgtgga tcatggccga cctggagaac
    24541 ggcctgttct ccggagtcaa ccagcacctg aactccaacg acccgacgat caactaccgg
    24601 tacaccaccg ccatgatcga gggcggccag aaccagtggg ccatcctcgg cggcaacgcc
    24661 cagtccggga acctgtccac cttctacagc ggcccgcgcc cgaacgtgtc gggctacaac
    24721 ccgatgcgca agcagggtgc gatcatcctc ggcaccggcg gcgacaacag caaggggtcc
    24781 gacggcacct tctacgaagg cgtcatgacc accggctacc cctcggccgc caccgagaac
    24841 gccatccagg cgaacatcac cgcggctgga tacggccgct agggcccgca tccgtgcgtc
    24901 gcgcgcgccg gtcaccgccg cgcgcgacgc accacgcccc gttgcacctg tccgccgcag
    24961 gcagcttcct ccgacgcacg catcgctgaa accgacgccc tgcccggctg tcaagcactg
    25021 gtgggagctt cggcggggcg ccggaacgcg ccgtaccact cgaggagcgc gatctccctg
    25081 gccacagtct cgtcctgctc cgggtcgccg gtcagcacct ggttcgccag ggcctggaac
    25141 ccgcctcaga cggtcactcg tgcggccgtt gccacgtcca cgtccggcgt ggtgcaccga
    25201 acaggacgcc agcctcccgc tggacctcca gcacaagatg tcagcccaca ccaagcaggt
    25261 ccgccgcatc gcgagcagcc actccccgtt cctctcccgc cccgccgaac tcgcggccct
    25321 gctcgacgac atcgtcgacc actgacacac cgcactgcac tgcaccgcac cgcacacccc
    25381 tcgggccgaa cc
//
