LOCUS       BGC0001155             21522 bp    DNA     linear   BCT 14-MAR-2014
DEFINITION  Planobispora rosea strain ATCC 53733 DNA-directed RNA polymerase,
            beta' subunit (rpoC) and hypothetical protein genes, complete cds;
            GE2270 biosynthesis gene cluster, complete sequence; and S10P
            (rpsJ), L3P (rplC), L4P (rplD), L23P (rplW), L2P (rplB), S19P
            (rpsS), L22P (rpsV), S3P (rpsC), L16P (rplP), L29P (rpmC), S17P
            (rpsQ), L14P (rplN), L24P (rplX), L5P (rplE), S14P (rpsN), S8P
            (rpsH), L6P (rplF), L18P (rplR), S5P (rpsE), L30P (rpmD), L15P
            (rplO), and preprotein translocase subunit SecY (secY) genes,
            complete cds.
ACCESSION   BGC0001155
VERSION     BGC0001155
KEYWORDS    .
SOURCE      Planobispora rosea
  ORGANISM  Planobispora rosea
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Streptosporangiaceae; Planobispora.
COMMENT     On Jan 15, 2014 this sequence version replaced KF366381.1.
            ##antiSMASH-Data-START##
            Version      :: False
            Run date     :: 2024-10-17 15:00:36
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 4200
            Orig. end    :: 25722
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     subregion       1..21522
                     /aStool="mibig"
                     /contig_edge="False"
                     /label="ribosomal"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..21522
                     /contig_edge="False"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            101..814
                     /gene="pbtR"
     CDS             101..814
                     /codon_start=1
                     /gene="pbtR"
                     /gene_functions="regulatory (smcogs) SMCOG1057:TetR family
                     transcriptional regulator (Score: 78.9; E-value: 1.1e-23)"
                     /gene_kind="regulatory"
                     /note="TetR transcriptional regulator"
                     /product="PbtR"
                     /protein_id="AGY49580.1"
                     /transl_table=11
                     /translation="MTSSRSNAERVVRIIDASAELLLQRGYRRVTVEEVASHAGVSKSS
                     VYLHWNTKDDIFYDALDRECAALVCEAVDRVRRNPAEILAHRMAANLLRIILDRPLLRA
                     LLMGDQAILGSLRHAKSSALRSRTAAIDELIHRYLSALQKNQLICPDIDLRITRKAVWE
                     MLRGMIFSAGTEPLGKPRSAELAQVMTVTVRRAFEPRGVPGIDRITAAAAEVFEAFDEL
                     IPTAENLDFERPMVL"
     gene            868..2691
                     /gene="pbtG1"
     CDS             868..2691
                     /codon_start=1
                     /gene="pbtG1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thiopeptide: YcaO"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thiopeptide: TIGR03604"
                     /gene_functions="biosynthetic (rule-based-clusters) LAP:
                     YcaO"
                     /gene_functions="biosynthetic (rule-based-clusters) LAP:
                     TIGR03604"
                     /gene_kind="biosynthetic"
                     /note="cyclodehydratase"
                     /product="PbtG1"
                     /protein_id="AGY49581.1"
                     /sec_met_domain="YcaO (E-value: 1.7e-73, bitscore: 238.3,
                     seeds: 127, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR03604 (E-value: 1.3e-102, bitscore:
                     333.5, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLADRLSAVPAGLDPDLVLAVSDAPDPAVLAAARATGRPVLPVIA
                     EMGHVRIGPLERPGEPGCSDCLSIRRHRAATRSAEREAVWLRHGESMAGAMSPLLVPAA
                     LDLVAALVAGAAAGRGGILLVDLADLAVTPHSFLPDPLCGRCGELPDDSPERARVTLVP
                     RPKPALDQYRVWDAEHELDRLIRTYVDDHTGLVNSLTPAALGSLAVAGAAIRLRGTTVF
                     EPGFGRSRSYRRSSAIALLEALERYGAIGPGGRRGTVRASYASLGDRAVDPRSLGLHPP
                     THYALPDFPYRPFTVDAVCRWVWGHSFAAGGPVLVPERNVYYGRSDDQPFCYELANGCA
                     LGSCLEEAIFHGILEVLERDAFLLTWYTRARAPRIDLGTARDPGIPLVAAAITAETGYL
                     VECYDITPDHGVPCVWALARTLSGEPATISAAAAGTSLEHAAAGALAELGPMVPTVREH
                     FPPNADRARTLAADGSRVRSMIDHYLVYGVRSAAERLSFLTEGTTRVPFPPPPEGFRHQ
                     DLTLDLEFLIDRLADVGLDVIVVDLTTPEHRAGGLRCVKVLVPGAVPMTFGEQNRRTWG
                     LPRLLDPAAVRGRGMPVRVHADLNPDPHPFP"
     gene            2688..5066
                     /gene="pbtB1"
     CDS             2688..5066
                     /codon_start=1
                     /gene="pbtB1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thiopeptide: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155:Lantibiotic dehydratase domain protein (Score:
                     51; E-value: 8.8e-16)"
                     /gene_kind="biosynthetic"
                     /note="dehydratase"
                     /product="PbtB1"
                     /protein_id="AGY49582.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 1.5e-23, bitscore:
                     72.8, seeds: 73, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNRAVARVGGLPLSALDALACPDATALAACVVSLTDELSRRAAVL
                     SDLLYEVIGAAEEHKPVLVAIRRDLHGLRRPKRIEVLPAALLDRVHEWISLWEQRARAR
                     AALPEVLAGEARTAWASLRELAAAPAVRHGLAHASPDLSAELEKWLADPGRRPRAGTLA
                     SLLRYVTRVAAKTSPFSTFTSVHRVHWEMEGTGWEIPDSPPTVVVEADVGLRLLVEFMV
                     PRWPGPAAARTVRLSPTAYMSGRKLLFLGPDGRTRALERTAALDALVELLRAEHGARWD
                     VVAGKLAAEDREQGEETLARLVRGGLVEAVVPVPGQAARPFAALADWARAAEVAHPLNR
                     IQQALDLTGPLGTGDPATSACTEAARRVTAELPALSLPAMPLPELRRRVLRESTVGAPV
                     TCALPEWRPALADLERVRRWLAVHDPMLPLRLSLADHVRDWFGPDSSPPLLEVYLRVEA
                     AQPGSPLHPDFLERPDPLADVADPRLRGLRDLRVRTIEALHGGRAEEMLGELPGWIGDP
                     GPVTCYVQPFHEEGELRLVLNTAHGGHGRGITRWSRLLGGSPVPVSPGYLAAELPGVFG
                     HSLNLRAPGTEWELDYPGAVGQAPPDRRIPLTELQVRHDQARGLVTLWWPRAGRRVVPV
                     HAGMMSETLLPPLARLLVEAFGTTYLTHPTLPAIPRASGPRIDLGRVTLARAQWTVGQD
                     AVPRREDDDADHFVAVQRWLRRTGIPRRCFVRVRERQVSRDRIAFDKRHKPVFIDFGSW
                     PSVLEFDRMVERTTGELEVAEALPDGDRAVEFAIEVGEP"
     gene            5063..6097
                     /gene="pbtO"
     CDS             5063..6097
                     /codon_start=1
                     /gene="pbtO"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007:cytochrome P450 (Score: 126; E-value: 3e-38)"
                     /gene_kind="biosynthetic-additional"
                     /note="P450 monooxygenase"
                     /product="PbtO"
                     /protein_id="AGY49583.1"
                     /sec_met_domain="p450 (E-value: 1.2e-10, bitscore: 30.8,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQYPLSRPEPLGVHPDYRRLRETCPVARVGSPYGPAWLVTRYAD
                     VAAVLTDARFSRAAAPEDDGGILLNTDPPEHDRLRKLIVAHTGTARVERLRPRAEEIAV
                     ALARRIPGEGEFISAFAEPFSHRVLSLFVGHLVGLPAQDLGPLATVVTLAPVPDRERGA
                     AFAELCRRLGRQVDRETLAVVLNVVFGGHAAVVAALGYCLLAALDAPLPRLAGDPEGIA
                     ELVEETLRLAPPGDRTLLRRTTEPVELGGRTLPAGALVIPSIAAANRDPDRPVGRRMPR
                     HLAFGRGAHACLGMALARMELQAALKALAEHAPDVRLPAGTGALVRTHEELSVSPLAGI
                     PIQR"
     gene            6222..6869
                     /gene="pbtX"
     CDS             6222..6869
                     /codon_start=1
                     /gene="pbtX"
                     /product="PbtX"
                     /protein_id="AGY49584.1"
                     /transl_table=11
                     /translation="MSAEHPYHDRLRALFAYLRKVDSDPVVASELQEDPEKALRAAGVD
                     QAFDRPEAFQAFVGKLSALSGEAWLATVHSMIELCENGSDVQPPTGPNISFRLSGDGSV
                     TAIANRGEVAKKVQPNPFYTSGKSASAGSRLRIYPEYATSELSARLSERYLSTFYQRTL
                     LKRVVLDPATVVEDADAGEGVTVSRSHYKGVEFDLHTRAEGADREIIAAFVR"
     gene            6914..8032
                     /gene="pbtM1"
     CDS             6914..8032
                     /codon_start=1
                     /gene="pbtM1"
                     /note="N-methyl transferase"
                     /product="PbtM1"
                     /protein_id="AGY49585.1"
                     /transl_table=11
                     /translation="MLSSALEVDIDEAAVAADLRELAAALDRSGYGEILTCFLPQKAQA
                     HIWAQTAAKIDGPLRTLMELFLLGRAVPQDDLPPRIAAVIPGLVSAGLVKTGQGAVWLP
                     NLILLRPMGQWLWCQRPHPSPTMYFGDDSLALVHRMVTYRGGRALDLCAGPGVQALTAA
                     LRSEHVTAVEINPVAAALCRTNIAMNGLSDRMEVRLGSLYDVVRGEVFDDIVSNPPLLP
                     VPEDVQFAFVGDGGRDGFDISWTILDGLPEHLSDRGACRIVGCVLSDGYVPVVMEGLGE
                     WAAKHDFDVLLTVTAHVEAHKDSSFLRSMSLMSSAISGRPAEELQERYAADYAELGGSH
                     VAFYELCARRGGGSARLADVSATKRSAEVWFV"
     gene            8107..9291
                     /gene="pbtM2"
     CDS             8107..9291
                     /codon_start=1
                     /gene="pbtM2"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thiopeptide: PF04055"
                     /gene_functions="other (smcogs) SMCOG1277:Radical SAM
                     domain protein (Score: 57.5; E-value: 1.7e-17)"
                     /gene_kind="biosynthetic"
                     /note="coproporphyrinogen III oxidase-related Fe-S
                     oxidoreductase"
                     /product="PbtM2"
                     /protein_id="AGY49586.1"
                     /sec_met_domain="PF04055 (E-value: 6.2e-22, bitscore: 68.9,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLIYVNVPFCNSKCHFCDWVTEVPLADLRLTPDSSPRQRYIAALV
                     QQIETHAPVLTGFGYRPEIMYWGGGTASILSIDEIEAVAGALSSRFDMSGLTEATIEGS
                     PESLDPDKLKLFRAAGFNRISIGVQAFDDARLRRIGRVHSAEQAVRAVEMAAEAGFDNI
                     NIDLIVGFPGQEVDEVSHMIQRAVTLPVNHFSVYPYRPTNGTVMRKQVRRGNSEIDVDE
                     QLRSYAYARDLLAEHGFDEYATAYFGGPRCESDEVYYKLTMDWIGFGSGANSLIGTRFL
                     LNERGALHRFSAAPQRFDSDIPASSPHLTRHFLAQALTTVDGMDARTFQQRTGRSLRAA
                     CEEPAVRRMLEQINRRGRLIIDSRGIRLHRDDMASTYITMNSVDLYAATEQIGG"
     gene            9417..9584
                     /gene="pbtA"
     CDS             9417..9584
                     /codon_start=1
                     /gene="pbtA"
                     /note="GE2270 precursor peptide"
                     /product="PbtA"
                     /protein_id="AGY49587.1"
                     /transl_table=11
                     /translation="MSEMELNLNDLPMDVFEMADSGMEVESLTAGHGMPEVGASCNCVC
                     GFCCSCSPSA"
     gene            9642..12131
                     /gene="pbtB"
     CDS             9642..12131
                     /codon_start=1
                     /gene="pbtB"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thiopeptide: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155:Lantibiotic dehydratase domain protein (Score:
                     56.4; E-value: 2.1e-17)"
                     /gene_kind="biosynthetic"
                     /note="lantibiotic dehydratase"
                     /product="PbtB"
                     /protein_id="AGY49588.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 8.7e-50, bitscore:
                     159.5, seeds: 73, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVEKGHEIVVRVAGVPAAVLGGLRLPHSAALVTHLIAEDHRLTA
                     EAAVLSDDLFELIGDAGPARAALVGLRRALAPGRRRPSARLIERCPLPEPLAGRITAWA
                     RARAEWDGRRRELDDLLTKERADVLGHVRAACADPAFRRGLFLSGAELSGTLDRWLADP
                     DRPPRPGKVLRIVKYLARASAKTSPFGSFMVSALTGWSDDGMGAPESVEVTEPSGAFLD
                     AVRDALLADPRLADRVPLRPNPSLTEAGDALMFVSGQTGERIATVGRVPAVELCLRHAE
                     SRPTAPRLAGLLTEAGADPGEAARFVSRMVTAQLLVPCPPVTDDDHDPFGAWARWADLP
                     ELRELSAALRPVRLGRHGRSGPSGPSGPSGPDAHRRRRERTAAALTAVAERLGIDPPAE
                     PAHEVEVGVGRPAPPALPDDVLADLDAVRRWLSVFDWKIPVRVSVGAYCREHFGPGSRT
                     PFLLVCRQATAALPHLFGPAAMPWFSDLTGSPRLRELDRLRERARGLARSGALDRREVL
                     DDTADWPAWLTSPASVGFYLQLLPGEPGKVVLNAVHAGHGRASGRLHHLLGRAGAAPER
                     PARPGPPLAEIGGRFGSALNTRTPSTLLEIDHPGAASGRDPGHRIRLGELMVVHDPETD
                     LAFLHSERFGRIEPVHLGMMGELALPAVAGFLERAFAPTYLFHPSVPPLISLRDLAGTA
                     ATRRFPRVSVGGVIVQRARWTVPADRVPARSGPDADHSGSDGDHLLALARWRHAEGIPE
                     RCFVRGWSPGAAFGKARKPLYVDFASWHLTTLFEREARSNAAVVIDEALPDPLAEGAPA
                     HVTEYHIEIDTGGTADA"
     gene            12124..13032
                     /gene="pbtC"
     CDS             12124..13032
                     /codon_start=1
                     /gene="pbtC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thiopeptide: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /note="lantibiotic dehydratase"
                     /product="PbtC"
                     /protein_id="AGY49589.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 2.1e-50, bitscore:
                     162.1, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPDQPTWLGAHLHYRGDLDMMLRDAVAPLVRALGTDFFFLRYWDG
                     GSHVRLRLRGADEAVVADHMNAYFAAHPAPETMTQQEYARVAAVLADREGMTRHLTSLR
                     PNNSVEFVPYRPETGKYGTGETLRAVERHFVESSRSALDIIGRSPTGNQRELAVLGILL
                     LAWYAAGVPEERLPGAAETLCRGWRGGHDLPEDRVEREFAGVRERVVRLAGSLRGLEPR
                     PDHPGTSLHAWAATFARLGAALAGPDRLRVLDNCAHLAANRLGVSMAAEVRLRLLAVRA
                     LRETASPRPFRCGGDGDLATL"
     gene            13013..14014
                     /gene="pbtD"
     CDS             13013..14014
                     /codon_start=1
                     /gene="pbtD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thiopeptide: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /product="PbtD"
                     /protein_id="AGY49590.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.3e-36, bitscore:
                     116.9, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTWRRFDVAYHDPDLDRLILAARPLLSESPGRSWFQRHWVRGPHL
                     ELWFDHPEPSWERVREVLGTHLRAHPSRTRIDPDRLLPQHRRLALAEQIDEPLLPFYDD
                     NTLHRAVPRSRVHVLGSAAAEDLFHDFHAAASTAAFDQLDAVVAGESRLGLAFELMIAA
                     AHAHAEGGITGGFVSFRSHAEAFLAGAAGLRERWEAEYRTRAEALRAQVAAVVTGTPRG
                     RAWTGLLDGFAGRGDELIASGALTVEPASPTAAAEPDTEFHRALRANRTWHDEVLRSPS
                     FRRYRLLLNLTYLQMSRLGVTAVQRSLLCHFAASAVEEEYGVSAIEIAVGGM"
     gene            14014..15384
                     /gene="pbtE"
     CDS             14014..15384
                     /codon_start=1
                     /gene="pbtE"
                     /gene_functions="biosynthetic (rule-based-clusters) LAP:
                     PF00881"
                     /gene_kind="biosynthetic"
                     /note="dehydrogenase"
                     /product="PbtE"
                     /protein_id="AGY49591.1"
                     /sec_met_domain="PF00881 (E-value: 2.8e-10, bitscore: 30.7,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVQADSVVAHRWALRSGVYRATAANGDLMLAAWPHTAMLGHASP
                     QLLALLDALAEGPVPVDEPGMSATLDRLRAGGWLSRTVSCAGRDLYTVTPLAAPTEAPA
                     PAGELRLSRFAVLRNTPEGLVLEMPGSWCDIRVHDPAVAALLADPSGDAGLPADAAAAV
                     RADLVAAGMLVAEEEEREPFERRQWSTHELWFHERSRLGNRGWFGGAHFGGTFWARGVH
                     EPPPARPSPYPGEAVPLARPDLATLRRTDPTLTTVLEDRESVRDHDDDAPITAEQLGEF
                     LYRCARVRLLRTIEGFEYSSKPYPGGGSAYELEVYPIVRLAADLTAGMYHYDAHDHLLR
                     PVQPLGHPSVRRLLKVATESSVTKAPPQVLLVISARVGRIMWKYEAMGYALMLKHVGVL
                     QQTMYAVATAMGLAPCALGSGDDLAFTGATDRDRLTECAVGEFMIGSRRKELATWQL"
     gene            15372..17168
                     /gene="pbtF"
     CDS             15372..17168
                     /codon_start=1
                     /gene="pbtF"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Thiopeptide_F_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Heterocycloanthracin_C_RRE"
                     /gene_kind="biosynthetic-additional"
                     /product="PbtF"
                     /protein_id="AGY49592.1"
                     /sec_met_domain="Thiopeptide_F_RRE (E-value: 3.6e-24,
                     bitscore: 74.9, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Heterocycloanthracin_C_RRE (E-value:
                     5.5e-14, bitscore: 42.1, seeds: 5, tool:
                     rule-based-clusters)"
                     /transl_table=11
                     /translation="MAALNVLLRPDAYYAEVDGGVYFISHQGETFIAGPTVHQWLDRLA
                     PLLDGTRTLDRLTAGLPADRAAFVTKLVGVLAERGLVRMVGPGTPDTLTDAERHEYRGL
                     LSYLGYFSDSPGHVLENVLDTPTVIIGSDPLAAELSRACAAAGLRKVEMADEVGTAQVV
                     VHVADRAEPERAVRLERLCAASGALLAQVMPVADGIWWQPAARGGGLASAWRRHRALAG
                     PVPAAGPPDPVAAKVVANQVAHDVFRLLTGLREETAPRLVVFDPRTMASTTHPIIPHPL
                     DLPAEPLDEAAFLDRITSLRTAPAVSEEEFSRRAKGLMDGRTGLFAEIDEGDLAQLPLH
                     VTATTVSDPCGRLGDAPRPVVTGAGFTFEEARYRAALAALARAGTLTLDERRLIDGHVH
                     AYDLVDHTARLVPAETVFGASRGAAAAYSWDEAVAAGLTAHAAALTLDGIAHVTEPFGR
                     VDLTEAPEYCLAMIRALGEKPAVYDVTGPLGAPTVVGTLSGGATACGAALTIEAAVAAC
                     LRDLLLVRQAEINDQPVYAPAPCAPPSPALQGDHLAPRRPGTDVPTLVARLAEQGRRPL
                     AVPLDHDPAVHAALPFVVQVVC"
     gene            17168..18904
                     /gene="pbtG"
     CDS             17168..18904
                     /codon_start=1
                     /gene="pbtG"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thiopeptide: YcaO"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thiopeptide: TIGR03604"
                     /gene_functions="biosynthetic (rule-based-clusters) LAP:
                     YcaO"
                     /gene_functions="biosynthetic (rule-based-clusters) LAP:
                     TIGR03604"
                     /gene_kind="biosynthetic"
                     /note="cyclodehydratase"
                     /product="PbtG"
                     /protein_id="AGY49593.1"
                     /sec_met_domain="YcaO (E-value: 2.8e-73, bitscore: 237.6,
                     seeds: 127, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR03604 (E-value: 4.6e-100, bitscore:
                     325.1, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRVPDSGELTVALEKGPRLPVRTELGRITVGPLERPGVPGCREC
                     VRVRERRVQPDARKAEAVRALHTPAASQWLTPLATDLVHTLVASEAAALAADAEPRTVN
                     AVLEIDLMTLEITRHRFLPDPLCAHCGDLPPDAPAELTLRSRRKLGGSPRTREIELDAL
                     LETYVDGRTGMIRPLKTGVQGGLTVASAMLPIRAGNGLEPGVGRTRNYRASKLTAVLEA
                     LERYGGVSPGGRRTVIRSAYRDIAGDAVHPDGFGTHPEENYDRPDFEFRRFTEDTVCRW
                     VWGYSFAQSRPVLVPENQVYYYARHMPDGEKPFVFEVSNGCALGSCLEEAILHGLLEVV
                     ERDAFLLTWHARRQVPVLDPALAADPVLPMQVAAITAETGHRVLCFDTTAEHGIPSVWV
                     MAVDAERRPDQPATAHAAGSALTLEKATMNALSELGPLLADVIRRYPQQRERAQAMVRD
                     PEEVVTMHDHSILYAAPEAADRLDFLIGRADGPKVGFGTDRFTGDDLTADLRAMIDAVL
                     AAGMDVVVVDQTTPEHLAGGFRCVKVLVPGALPMTFGHRHRRLGNLPRLETVRTTDPHP
                     FP"
     gene            18921..19289
                     /gene="pbtH"
     CDS             18921..19289
                     /codon_start=1
                     /gene="pbtH"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thiopeptide: thio_amide"
                     /gene_kind="biosynthetic"
                     /product="PbtH"
                     /protein_id="AGY49594.1"
                     /sec_met_domain="thio_amide (E-value: 5.9e-38, bitscore:
                     119.1, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYVVIVAFDLKDSAIDFAELRAWVHDRAADDYSRLPGMRFKAWFS
                     DERKRLWGAVYLVESMSSFDRDKIPLLPDGATGPVGTRPTSIMFLELEAFVAGPDGIAG
                     IEALTRQGLSMVGGSHDH"
     gene            19339..20505
                     /gene="pbtM3"
     CDS             19339..20505
                     /codon_start=1
                     /gene="pbtM3"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thiopeptide: PF04055"
                     /gene_kind="biosynthetic"
                     /note="coproporphyrinogen III oxidase-related Fe-S
                     oxidoreductase"
                     /product="PbtM3"
                     /protein_id="AGY49595.1"
                     /sec_met_domain="PF04055 (E-value: 4.6e-20, bitscore: 62.8,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLLYVNVPFCNSKCHFCDWVVDVPVSDLRLTPVSAGRIDYLEALR
                     TQIRIHAPALREAGYRSEVMYWGGGTATVLTEREIEQTYACLAAELDLSSLAEATIEGS
                     PESVDLAKLTFMRDLGFDRVSLGVQSFDETRLRRIGRAHSAGQAVQSVEAAHAAGFDNI
                     NIDLIVGFPDQSLEEVEEMIRRALDLPVNHFSVYSYRATEGTVMRKQIERSGTEILLEH
                     QLRSYRLAADMLAAAGHPEYAVSYFGVPRCLADEAYYRLSMDWIGFGTGANSLINQRYL
                     LNGRGRMRDFTSKPGEFEVNLPAATGSLTVQWLPRALGTSEGIDAVTFQRRTGMSLRAA
                     CEEPDLNAFLRQVNRFGDLVVDRTGIRLADDDRSSVLSRTFAAMGWVS"
     gene            20515..21522
                     /gene="pbtM4"
     CDS             20515..21522
                     /codon_start=1
                     /gene="pbtM4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:O-methyltransferase (Score: 295.5; E-value:
                     8.7e-90)"
                     /gene_kind="biosynthetic-additional"
                     /note="O-methyl transferase"
                     /product="PbtM4"
                     /protein_id="AGY49596.1"
                     /transl_table=11
                     /translation="MRTVLAAADLATPMAVRVAATLRLADRIAAGTDSAAALAAAAGAD
                     EAALTRLLRYLVARDIFREPSPGRFALSPAAELLRGDRPERLRDWLDLTGPIGRADLAF
                     GSLLDVVLTGRPGYPMIHGRGFWDDLAGRPELAAAYDALMGGKRDWAATTLAALDWSRS
                     RHVVDVGGGNGTLLSCVLAAHRHLRGTVVDRPSSAEAAGAVLASAGVADRCEFRAGDFF
                     EPLPVKGADTYLLSSIVHDWDDSSAVAILRRCAEAAGPGGRILLCELMAGGGRDQRAVT
                     QMDLCMLVYFGGRERTGDEFAALAERAGLELRTVTPLPPHDWGNSLIECVVTGG"
ORIGIN
        1 gcgtaatgtc cacctggtgg gcgtatagtt attgggctgg gggcataatg actatccgta
       61 tccggtcgtg caacgcgctg cggtcgcggc gggaaagcgc gtgacgagct cgcgcagtaa
      121 tgccgaacga gtggtccgaa tcatcgacgc atctgcggag cttttactcc agaggggata
      181 tcgacgggtg accgtcgagg aggtcgccag ccatgccggt gtctccaaga gcagcgtcta
      241 cctgcactgg aacacgaagg acgacatctt ctacgacgct ctcgaccgcg agtgcgccgc
      301 gctcgtgtgc gaggccgtcg accgcgtcag acgcaacccg gccgaaatcc tggctcaccg
      361 gatggcggcc aatctgctcc ggatcatcct ggacaggccg ctgctgcggg cgctgctgat
      421 gggtgaccag gcgattctgg gatcgctccg ccatgcgaag tcgtccgctc tccgatcccg
      481 gacggcggca attgacgagc tgattcaccg atatctctca gcgctgcaga aaaaccaact
      541 catctgtccc gacatcgatc tgcgcatcac ccggaaagcg gtgtgggaaa tgctgcgcgg
      601 catgattttc tcggcgggga cggagccgtt gggcaagccg cgctccgccg agctggcgca
      661 ggtcatgacg gttaccgtgc ggcgggcgtt cgagcccagg ggcgtaccgg ggatcgaccg
      721 gatcaccgcc gccgcggccg aggtcttcga ggcgttcgac gaactcattc cgaccgcgga
      781 gaacctggac ttcgagcgcc cgatggtgct atgaccgtgg cgccggcata tctttctccg
      841 gtttcgagga cgcttgtcgg aaacggtgtg ctcgccgacc ggctctcggc ggtgccggcc
      901 gggctcgatc cggatctggt gctggccgta tcggacgcgc ccgatcccgc ggtgctcgcc
      961 gcggcgagag cgacgggccg cccggtgctg ccggtgatcg ccgagatggg gcacgtccgc
     1021 atcggaccgc tggaacggcc gggcgagccg gggtgctccg actgcctgag catccgcaga
     1081 catcgtgccg ccacccggtc ggccgaacgc gaggcggtgt ggctgagaca cggcgagagc
     1141 atggccggtg cgatgtcgcc gctgctcgtg ccggcggcac tggacctggt ggccgcgctc
     1201 gtcgccggag cggcggcggg gcgcggcggc attctgctgg tcgacctcgc cgacctcgcc
     1261 gtgacgccgc actcgttcct gcccgatccg ctctgcggcc ggtgcgggga actgccggac
     1321 gacagcccgg agcgtgcgcg cgtcacgttg gtgccgcggc cgaagcccgc tctggaccag
     1381 taccgggtgt gggacgccga acacgaactg gaccgcctga tccggaccta cgtcgacgac
     1441 cacaccggtc tcgtgaactc gctcaccccg gcggcgctcg gttcgctcgc cgtcgcggga
     1501 gcggcgatcc ggctacgcgg gacgacggtg ttcgaaccgg gcttcggccg gtcccgcagc
     1561 taccgccgca gctcggccat cgcgttgctc gaagcgctgg agcggtacgg cgccatcggc
     1621 cccggcggca ggcgcggaac cgtacgcgcg agctacgcgt ccctgggcga ccgggcggtg
     1681 gatccacggt cgctgggcct gcacccgccc acgcactacg cgctgccgga cttcccgtac
     1741 cggccgttca cggtcgacgc ggtgtgccgt tgggtgtggg ggcactcgtt cgcggccggt
     1801 ggtcccgtgc tggtgccgga gcgcaacgtc tactacgggc gctccgacga ccagccgttc
     1861 tgctacgagc tcgccaacgg ctgcgccctg ggatcgtgcc tggaggaggc gatcttccac
     1921 ggcatcctgg aggtgctgga acgcgacgcg ttcctgctga cctggtacac ccgtgcgcgg
     1981 gccccgcgca tcgatctcgg cacggcccgc gatccgggga tcccgctggt cgccgcggcg
     2041 atcaccgccg agaccggtta cctcgtcgag tgctacgaca tcacgcccga ccacggagtg
     2101 ccgtgcgtgt gggcgctggc ccgtacgctg tccggtgagc ccgccacgat cagcgccgcc
     2161 gccgccggga ccagcctgga acacgccgcc gcgggggcgc tcgccgaact cggcccgatg
     2221 gtgccgaccg tgcgcgagca cttccccccg aacgccgacc gagcacggac gctggccgcc
     2281 gacggcagcc gggtacggtc gatgatcgac cattacctgg tgtacggagt gcggtcggcg
     2341 gcggagcggt tgtcgttcct caccgagggg acgacgcggg tgccgttccc accgcctccc
     2401 gaagggttcc ggcaccagga tctgaccctc gacctggagt ttctgatcga ccggctcgcg
     2461 gacgtcgggc tcgacgtgat cgtggtcgat ctgacgacac cggagcatcg cgcgggcggc
     2521 ctgcgctgcg tgaaggtgct cgtgcccggt gcggtcccga tgacgttcgg ggagcagaac
     2581 cgccgcacct gggggctgcc gcgactgctg gacccggccg cggtgcgcgg acgggggatg
     2641 ccggtgcgtg tccacgccga cctgaacccc gacccccacc cgttcccgtg aaccgcgcgg
     2701 tcgccagggt cggcggactg ccgctgtccg ctctggacgc tctggcctgc cctgacgcca
     2761 cggctctggc cgcctgtgtc gtctcgctca ccgacgagtt gtcccggcgg gccgcggtgc
     2821 tgtccgacct cctgtacgag gtgatcggcg ccgcggagga gcacaagccc gtcctggtgg
     2881 cgatccggcg ggacctgcac gggctgcgtc ggcccaagcg gatcgaggtg ctgcccgcgg
     2941 cgctgctgga tcgggtccat gagtggatct ccctctggga acagcgcgcg cgggcccgcg
     3001 ccgcgttgcc cgaggtgctc gcgggtgagg cccggacggc ctgggcgtcg ctgcgggagc
     3061 tggccgccgc tccggcggta cggcacgggc tcgcgcacgc cagcccggac ctgtccgcgg
     3121 aactggagaa gtggctcgcc gacccggggc gacggccccg ggcggggaca ctggcgagcc
     3181 tgctgcgcta cgtcacccgg gtggcggcca agacgagtcc tttcagcacg ttcacgagcg
     3241 ttcaccgcgt gcactgggag atggagggga cgggctggga gatacccgac tcaccgccga
     3301 ccgtggtggt cgaggccgat gtgggactcc ggctgctggt ggagttcatg gtgccacgat
     3361 ggccaggacc ggccgcggcg cgtacggtcc ggctgtcgcc gaccgcgtac atgtccgggc
     3421 ggaagctgct cttcctcggc ccggacgggc ggacgcgcgc actcgaacgg acggcggcgc
     3481 tggatgccct cgtcgagttg ctgcgtgccg agcacggggc ccggtgggac gtggtggccg
     3541 gcaagctcgc cgcagaagac cgcgagcagg gggaggagac cctggcccgg ctggtgcgcg
     3601 gcgggctggt ggaggcggtg gtgccggtgc ccggccaggc ggcgaggccg ttcgcggccc
     3661 tcgcggactg ggcccgggcc gccgaggtcg cccatccgct gaaccgcatc cagcaggcac
     3721 tggacctcac cggacccctc ggcaccggtg acccggcgac atcggcctgc accgaggcgg
     3781 cgcgtcgcgt caccgccgaa ctccccgcgc tcagccttcc cgccatgccg ctccccgagc
     3841 tgcgccgccg cgttctgcgc gagtcgaccg tcggcgcgcc cgtcacctgc gcgctcccgg
     3901 agtggcgacc ggccctggcc gacctggaac gggtccgccg ctggctggcg gtccacgatc
     3961 cgatgttgcc gctccgcctt tccctggcgg accacgtccg cgactggttc ggcccggact
     4021 ccagcccgcc gctgctggag gtgtacctcc gggtcgaggc ggctcagccg gggtcgccgc
     4081 tccaccccga cttcctggaa cgccccgacc ccctggcgga tgtcgccgac ccgcgcctgc
     4141 gcggactgcg cgacctgcgc gtccggacga tcgaggcgct tcacggaggg cgggccgagg
     4201 agatgctcgg cgaactgccg gggtggatcg gcgacccggg accggtcacc tgctacgtcc
     4261 agcccttcca tgaggagggc gagctcaggc tggtcctcaa caccgcgcac ggcggccacg
     4321 gccggggcat cacccgctgg agcagacttc tgggcggcag tccggtgccg gtctcccccg
     4381 gctacctggc cgccgagctg ccgggggtct tcgggcacag cttgaacctg cgcgctcccg
     4441 gcacggaatg ggaactcgac tacccgggcg cggtaggcca ggcaccgccg gatcgccgca
     4501 ttccgctcac cgagttgcag gtccggcacg accaggccag gggtctcgtc accctgtggt
     4561 ggccgcgtgc cggccggcgg gtcgtcccgg tacacgcggg catgatgtcg gagacgctcc
     4621 tgccgccgct ggcgcggctg ctcgtcgagg cgttcggtac cacctacctg acccacccca
     4681 ccctcccggc gatcccgcgg gcgagcggcc ctcggatcga tctcggccgt gtcaccctcg
     4741 ccagagccca gtggacggtc ggccaggacg ccgttccccg gcgggaagac gacgacgccg
     4801 atcacttcgt cgccgtccag cggtggctgc gccgcaccgg gattccgcgc cgttgcttcg
     4861 tgcgcgtccg ggaacgccag gtgagcaggg accggatcgc gttcgacaaa cggcacaagc
     4921 cggtgttcat cgacttcggc agctggccgt cggtgctgga gttcgaccgg atggtcgagc
     4981 ggacgaccgg cgagctggaa gtggcggagg cgctgcccga cggcgatcgg gccgtggagt
     5041 tcgcgatcga ggtgggggaa ccgtgacgca gtatccactg agccgtccgg agccgctcgg
     5101 ggtccacccc gactaccggc ggctccgtga gacatgcccg gtggcgcggg tcggctcgcc
     5161 ctacggcccg gcctggctgg tcacccgcta cgcggacgtg gcggcggtgc tgaccgacgc
     5221 gcggttcagc cgtgcggcgg cgccggagga cgacggtggc atcctgctca acacggaccc
     5281 gccggagcac gacaggctgc gcaagctcat cgtggcgcac accggaacgg cgcgggtcga
     5341 gcggctccgg ccgagggccg aggagatcgc ggtcgcgctg gcacggcgga tcccgggtga
     5401 gggcgagttc atcagcgcgt tcgccgagcc gttctcgcat cgggtgctca gcctgttcgt
     5461 cgggcacctg gtcggcctgc ccgcccagga cctgggtccg ctggccaccg tcgtgacgct
     5521 cgcgccggtg cccgaccggg agcggggagc cgccttcgcc gagctgtgcc ggcggctcgg
     5581 gcgccaggtg gaccgggaaa cgctcgcggt ggtgctcaac gtcgtcttcg gcgggcacgc
     5641 ggcggtggtg gccgcgctgg gctactgcct gctggccgcg ctggacgcac cgctgccgag
     5701 gctggcgggc gatcccgaag gcatcgccga gctggtcgag gagacgctcc gcctcgcgcc
     5761 accgggcgac cggactctgc tgcgccgtac cacggagccg gtggagctgg gcgggcggac
     5821 actccccgcg ggcgcgttgg tgatcccgtc gatagcggcg gcgaaccgcg acccggaccg
     5881 gcccgtcggc cggcgcatgc cccggcatct ggcgttcggc cgaggcgcgc acgcgtgcct
     5941 cgggatggcg ctcgccagga tggagctgca ggcggcgctc aaggcgctgg ccgagcacgc
     6001 ccccgacgtg cggcttccgg ccgggacggg cgccctcgtg cgaacacatg aagaattgtc
     6061 ggtgagccct cttgcgggaa tcccgattca gaggtaagag cgaaaagtcg agaatacggt
     6121 tttggtcagc gggttcggat tccttgcgat gtccgtaacg cgacaatagc ctcgaatcag
     6181 cgagcagaaa gactagcgct gtagggattc gagggagaac cgtgtcggca gaacaccctt
     6241 accacgacag gctgcgcgcc ttgttcgcgt atcttcggaa agtcgacagc gacccggtcg
     6301 tggcgtccga gctccaggag gacccggaga aagccctgcg tgcagcaggt gtggatcagg
     6361 cattcgaccg tccggaagcc tttcaggctt tcgtcgggaa actgtcggcg ctgagcggtg
     6421 aagcgtggct cgcgactgtt cactcgatga ttgaattatg tgagaacggc tccgacgtgc
     6481 agccgccgac ggggccgaat atctcattcc ggctctccgg ggacggcagt gtcaccgcta
     6541 tcgccaaccg cggcgaagtc gccaagaagg tgcagcccaa tccgttctac acgagcggga
     6601 agagcgcgtc ggcgggcagc cggctgcgca tttaccccga gtacgcgacc agcgagctgt
     6661 cggcgcggct gagcgagcgt tatctctcga cgttctacca gcgcaccctg ctcaagcgcg
     6721 tcgttctcga cccggccacc gtcgtcgagg acgcggacgc cggtgagggc gtcaccgtga
     6781 gccggtcgca ctacaagggc gtcgagttcg acctgcacac cagggccgag ggcgcggacc
     6841 gcgagatcat cgccgcgttc gtgcgctgat catcggcaca acgaccacga catcacatcc
     6901 acggaggctc gggatgctca gcagcgccct ggaagtagac atcgacgagg cggccgtcgc
     6961 cgccgacctc agagaactgg ccgcggcact cgaccgcagc ggctacggag agatcctgac
     7021 gtgcttcctg ccgcagaaag cgcaggccca catctgggcg cagaccgcgg cgaagatcga
     7081 tggtccgctg cggaccctga tggagctctt cctgctcggc cgcgcggtgc cgcaggacga
     7141 cctcccgccc cggatcgccg cggtgatccc cggcctcgtc tccgcggggc tggtcaagac
     7201 ggggcagggc gccgtgtggc tgcccaacct catcctgctc cggccgatgg gccagtggct
     7261 gtggtgccag cgcccgcacc cctcgcccac catgtacttc ggcgacgact cgctcgcgct
     7321 ggtgcaccgc atggtgacct accgcggcgg ccgcgccctc gacctgtgcg cggggccggg
     7381 cgtgcaggcg ctgacggcgg cgctgcgcag cgagcacgtc acggcggtcg agatcaaccc
     7441 ggtggcggcg gcgctgtgcc gtaccaacat cgccatgaac ggactctcgg accggatgga
     7501 ggtccgcctc ggcagcctct acgacgtcgt gcggggcgag gtcttcgacg acatcgtgtc
     7561 gaacccgccg ctgctgccgg tccccgagga cgtgcagttc gcgttcgtcg gcgacggcgg
     7621 ccgtgacggc ttcgacatct cctggaccat cctcgacggc ctgcccgagc atctgtccga
     7681 ccgcggagca tgccgcatcg tcggctgcgt gctgagcgac ggctacgtgc ccgtcgtgat
     7741 ggaaggcctc ggcgaatggg cggcgaagca cgacttcgac gtgctgctga ccgtcaccgc
     7801 ccatgtcgag gcgcacaagg actcctcctt cctgcgcagc atgtcgctga tgtcgagcgc
     7861 gatctccggc aggcccgccg aggaactgca ggagcgctac gccgcggact acgccgagct
     7921 cggcggctcc cacgtggcgt tctacgagct gtgcgcgcgg cgcggcggcg gctcggcccg
     7981 gctcgcggac gtctccgcca ccaagcgctc cgccgaggtc tggttcgtct gacctgccac
     8041 cgaccggacg ggatcgctat gtcgacgaca cttcgcggaa caggcggcgc agtcgccgag
     8101 cagcccttgc tgatctacgt gaacgttccg ttctgcaact ccaaatgcca cttctgcgac
     8161 tgggtcaccg aggtgcccct cgcggatctg cggctcacgc cggactcctc gccgcggcag
     8221 cgttacatcg ccgcgctggt gcagcagatc gagacccacg ccccggtcct gaccggcttc
     8281 ggctaccggc cggagatcat gtactggggt ggcggcacgg ccagcatcct ctcgatcgac
     8341 gagatcgagg cggtggccgg cgcgctgtcg tcgcggttcg acatgagcgg actcaccgag
     8401 gccaccatcg agggcagtcc ggaatccctg gacccggaca aactgaagct gttccgcgcg
     8461 gccgggttca accggatcag catcggcgtc caggcgttcg atgacgcccg cctgcgtcgc
     8521 atcggccgcg tccactccgc ggaacaggcg gtgcgcgcgg tcgagatggc cgccgaggcg
     8581 gggttcgaca acatcaacat cgacctgatc gtcggattcc ccggccagga ggtcgacgag
     8641 gtgtcccaca tgatccagcg ggccgtcacc ctgccggtca accacttctc cgtgtacccg
     8701 taccgtccga cgaacgggac ggtgatgcgc aaacaggtac ggcgcggcaa cagcgagatc
     8761 gatgtggacg agcagctgcg gtcctacgcc tacgcccgtg acctgctcgc cgaacacgga
     8821 ttcgacgagt acgccaccgc ctacttcggc ggcccccggt gcgagtccga cgaggtctac
     8881 tacaagctca ccatggactg gatcggattc ggctccggtg cgaactccct gatcgggacg
     8941 cggttcctgc tgaacgagcg gggggccctc caccggttca gcgcggcgcc gcagcggttc
     9001 gactccgaca tcccggcgtc ctcaccccac ctgacacgcc atttcctggc gcaggcgctg
     9061 accaccgtgg acggcatgga cgcgcggacg ttccagcagc gcaccggccg ttcgctgcgg
     9121 gcggcgtgcg aggagcccgc cgtacggcgg atgctcgagc agatcaaccg gcgtggccgg
     9181 ctgatcatcg actcgcgcgg catccgtctg caccgcgacg acatggcctc gacctacatc
     9241 acgatgaaca gcgtcgacct gtacgccgcg accgagcaga tcggcggatg accacgggtc
     9301 ctcccgccga tcccgctcca cagtcttcgc gatcccgtgt gtccgtccca tggggggacg
     9361 ggcgtgccgg tcgaccgcca tggggtcgtg gaggaacgac aagacaagga aaggagatga
     9421 gcgagatgga gttgaacctt aacgacctgc ccatggacgt cttcgagatg gccgacagcg
     9481 gcatggaagt tgagtcactc accgcgggac acgggatgcc cgaggtcggt gcctcgtgca
     9541 actgcgtgtg cggcttctgc tgttcctgca gcccgtccgc gtgacgatca aggagtgccg
     9601 ccggcctcgg ccggcggcac tccgcctgcg agggggagac gatgcgtgtg gagaaaggcc
     9661 acgagatcgt ggtccgggtc gcgggggtgc ccgcggccgt tctcggcgga ctgcgcctgc
     9721 cgcactccgc cgcactcgtc acgcatctca tcgcggagga ccaccggctg acggccgagg
     9781 ccgccgtgct ctccgacgac ctcttcgagc tgatcggcga cgccggaccc gcgcgcgccg
     9841 cgctggtcgg cctgcgacgc gcgctcgccc ccggacgtcg ccgcccctcc gcgcgactga
     9901 tcgaacggtg ccccctgccg gagcccctgg ccggccggat caccgcgtgg gcgcgggcac
     9961 gggcggaatg ggacggacgg cgccgcgaac tcgacgacct gctgacgaag gaacgcgccg
    10021 acgtgctcgg ccacgtacgc gcggcctgcg ccgaccccgc gttccggcgg ggcctgttcc
    10081 tgtccggcgc cgaactgtcc ggcacgctcg accgctggct ggccgacccg gaccgcccgc
    10141 cccggcccgg aaaggtgctc agaatcgtca aatacctcgc gcgcgcctcg gccaagacca
    10201 gcccgttcgg ctccttcatg gtgagcgcgc tcaccggctg gagcgacgac ggcatgggcg
    10261 caccggagtc cgtcgaggtg accgagccgt ccggcgcgtt cctcgacgcc gtccgtgacg
    10321 cgttgctcgc cgacccgcgg ctggctgacc gggtgccgtt gcgtcccaac ccgagcctga
    10381 ccgaggccgg tgacgcgctg atgttcgtgt ccgggcagac cggggagcgg atcgccacgg
    10441 tcgggcgggt gcccgcggtc gagctctgcc tgcggcacgc cgagtcccgg cccaccgcgc
    10501 cccggctggc cgggctgctg accgaggcag gcgccgaccc cggcgaggcc gcccggttcg
    10561 tctcccggat ggtgacggcg cagctgctgg tgccgtgccc gccggtcacc gacgacgatc
    10621 acgacccgtt cggcgcctgg gcccgctggg cggaccttcc cgaactgcgc gagctgtcgg
    10681 ccgcgttgcg tcccgtacgg ctcggacggc atggccgctc cggaccctcc ggaccctccg
    10741 gaccgtccgg cccggacgcc caccggcggc gccgggagag gaccgccgcc gcgctcaccg
    10801 ccgtggcgga acgtctcggc atcgacccgc ccgccgaacc cgcgcacgag gtcgaggtcg
    10861 gcgtcggcag accggcgccg ccggcgctgc ccgacgacgt gctcgccgat ctggacgccg
    10921 tccgccgatg gctgtcggtg ttcgactgga agatccccgt ccgggtgagc gtgggcgcgt
    10981 actgccggga gcacttcggc cccggttccc ggacaccgtt cctgctggtg tgccggcagg
    11041 ccacggcggc cttgccccac ctgttcggac cggccgcgat gccgtggttc tccgacctga
    11101 ccggcagccc acgcctgcgc gagctggacc gcctccggga gcgggcccgc gggctggccc
    11161 gctcgggcgc tctcgaccgc cgggaggtcc tggacgacac cgccgactgg cccgcgtggc
    11221 tgacctcacc cgcctccgtc ggcttctacc tgcagctcct tcccggagag cccgggaagg
    11281 tcgtgctgaa cgccgtccac gccggacacg gccgggcgtc cggacgcctc caccacctcc
    11341 tcggccgggc gggcgccgca ccggagcgcc ccgcgcggcc gggcccgccc ctggccgaga
    11401 tcggcgggag gttcggttcg gcgctcaaca cccgcacgcc gagcacgctc ctggagatcg
    11461 accatcccgg cgcggcctcc ggccgcgacc ccggccatcg gatccgtctc ggcgagctca
    11521 tggtcgtcca cgacccggag accgatctgg ccttcctgca cagcgagcgg ttcgggcgga
    11581 tcgaaccggt gcacctcggc atgatgggcg agctggcgct gcccgccgtg gccgggttcc
    11641 tcgaacgcgc cttcgcgccc acctacctgt tccacccgag cgtccccccg ctgatctccc
    11701 tgcgagacct cgccggaacc gccgcgaccc ggcggttccc ccgcgtgtcc gtgggcggcg
    11761 tcatcgtgca gcgtgcccgc tggaccgtgc ccgccgaccg ggtgcccgcc cgttcgggac
    11821 cggacgcgga ccattcggga tcggacggag accatctgct cgccctcgcc cggtggcggc
    11881 acgccgaagg catccccgaa cggtgcttcg tccgcggctg gagccccggc gccgcgttcg
    11941 gcaaggcccg caaacccctg tacgtcgatt tcgcctcctg gcacctgacg accctgttcg
    12001 agcgggaggc acgctcgaac gccgccgtcg tcatcgacga ggccctgccg gaccccctgg
    12061 ccgaaggcgc tccggcccac gtgaccgagt accacatcga gatcgacacc ggagggacgg
    12121 ctgatgcctg accagccgac ctggctcgga gcgcacctgc actaccgcgg cgacctcgac
    12181 atgatgttgc gggacgcggt ggcgccgctg gtgcgcgcgc tcggcaccga cttcttcttc
    12241 ctgcgctact gggacggagg cagccacgtg cggctgcggc tgcgcggagc cgacgaggcc
    12301 gtcgtcgccg accacatgaa cgcgtacttc gccgcgcatc ccgcaccgga gaccatgacc
    12361 cagcaggagt acgcccgggt cgccgcggtg ctggccgacc gcgagggcat gacgcgccac
    12421 ctcacatcgc tccggccgaa caactccgtg gagttcgtgc cctaccggcc cgagaccggc
    12481 aaatacggca ccggggagac gttacgcgcc gtcgagcggc acttcgtcga atccagccgg
    12541 tccgcgctgg acatcatcgg ccgctcaccg accggcaacc agcgggaact cgccgtgctg
    12601 ggcatcctgc tgctggcctg gtacgccgcc ggggtgccgg aggaacggct gcccggcgcg
    12661 gccgagacgt tgtgccgggg ctggcgcggt ggtcacgacc tgcccgagga ccgggtggaa
    12721 cgagagttcg ccggcgtgcg ggagcgggtc gtgcgactgg ccggctcgct gcgcggcctc
    12781 gaaccgaggc cggatcatcc cggcaccagc ctgcacgcgt gggcggcgac gttcgcgcgg
    12841 ctcggcgccg cgctggccgg accggaccgg ctgcgggtgc tcgacaactg cgctcacctg
    12901 gcggccaacc ggctgggcgt gtccatggcg gccgaggtgc gcctgcggct gctcgccgta
    12961 cgggcgttgc gtgagacggc ttccccgaga ccgtttcggt gcggaggtga cggtgacctg
    13021 gcgacgcttt gacgtggcct accacgaccc ggatctcgac cggctgatcc tggcggcgcg
    13081 gccgctgctc tcggagagcc ccggccgcag ctggttccag cggcactggg tacgcggccc
    13141 gcatctggag ctctggttcg accacccgga accctcgtgg gagcgggtgc gggaggtgct
    13201 gggcacccac ctgcgcgccc acccgtcccg caccaggatc gacccggacc ggctgctgcc
    13261 ccagcaccgc cgcctggccc tcgccgagca gatcgacgag ccgctgctgc ccttctacga
    13321 cgacaacacg ctgcaccggg ccgtgccgcg gtcccgcgtg cacgtgctgg gcagcgcggc
    13381 ggccgaggat ctgttccacg acttccacgc cgccgccagc accgcggcgt tcgaccagct
    13441 cgacgcggtg gtggcggggg agtcccggct ggggctggcg ttcgagctga tgatcgcggc
    13501 ggcgcacgcc cacgccgagg gcggcatcac cggcgggttc gtgtcgttcc gctcacacgc
    13561 cgaggcgttc ctggccggcg ccgccggcct gcgcgagcgc tgggaggccg agtaccgcac
    13621 ccgcgcggag gcgttgcgcg cgcaggtcgc cgccgtggtc accgggaccc cgcgcggccg
    13681 ggcctggacc gggttgctcg acgggttcgc cggccgcggc gacgagttga tcgcgtccgg
    13741 cgccctgacg gtcgagcccg cctcaccgac cgcggccgcc gagccggaca ccgagttcca
    13801 ccgggcgtta cgcgccaacc ggacctggca cgacgaggtg ctgcggtcac cgtcgttccg
    13861 ccggtaccgg ctgctgctca acctgacgta cctgcagatg tcccggctgg gggtgaccgc
    13921 cgtgcagcgg tcgctgctgt gccacttcgc cgcctcggcg gtcgaggagg agtacggggt
    13981 gtccgccatc gagatcgccg taggaggcat gtgatgtcag tacaggctga ttcggtcgtg
    14041 gcgcaccggt gggcgctgcg gtccggcgtc taccgcgcca ccgcggccaa cggcgacctc
    14101 atgctcgcgg cctggccgca caccgcgatg ctcgggcatg cgtccccgca gctgctggcg
    14161 ttgctggacg cgctggccga aggaccggtg ccggtcgacg agcccggcat gtcggccacg
    14221 ctggaccggt tgcgcgcggg cggctggctc tccaggacgg tctcctgcgc gggacgcgac
    14281 ctctacacgg tcactccgct cgccgcgccc accgaggctc cggcgcccgc gggggagctg
    14341 aggctgtccc gcttcgcggt gctgcggaac accccggagg ggctggtgct ggagatgccc
    14401 ggctcgtggt gcgacatccg cgtgcacgac cccgcggtgg ccgcgctgct cgccgacccg
    14461 tccggtgacg cggggctgcc cgccgacgcc gccgcggcgg tgcgcgccga tctggtcgcc
    14521 gccgggatgt tggtggcgga ggaggaggag cgggagccgt tcgaacggcg gcagtggagc
    14581 acgcacgaac tgtggttcca cgaacgcagc aggctcggca accgcggctg gttcggcggc
    14641 gcccacttcg gcggcacctt ctgggcgcgc ggcgtgcacg agcccccgcc cgcgcggccg
    14701 tcgccctacc ccggcgaggc cgtccccctc gcacggccgg atctcgcgac gctccgccgc
    14761 accgatccga cgctcacgac cgtgctggag gaccgggaga gcgtccgcga ccacgacgac
    14821 gacgccccga tcaccgccga gcagctgggt gagttcctct accgctgcgc acgggtgcgc
    14881 ctgctccgca ccatcgaggg gttcgagtac tccagcaagc cctatcccgg cggcgggtcc
    14941 gcgtacgagc tggaggtgta cccgatcgtc cggctggccg cggacctgac ggcgggcatg
    15001 taccactacg acgcccatga ccacctgctc cgccccgtcc agccgctggg ccacccgtcg
    15061 gtgcgcaggt tgctgaaggt cgccaccgag tcgtccgtga cgaaggcgcc gccccaggtg
    15121 ctgctcgtga tcagcgcacg ggtcggccgc atcatgtgga agtacgaggc catgggctac
    15181 gccctgatgc tcaagcacgt cggcgtgctg cagcagacga tgtacgcggt cgcgaccgcc
    15241 atgggcctgg ccccctgtgc gctgggcagc ggcgacgacc tggcgttcac cggcgccacc
    15301 gaccgggacc ggctcaccga gtgcgcggtc ggggaattca tgatcggcag ccgtaggaag
    15361 gagctcgcga catggcagct ctgaacgtcc tgctgcgccc cgacgcgtac tacgccgagg
    15421 tcgacggcgg cgtctacttc atcagccacc agggcgagac gttcatcgcc ggtcctacgg
    15481 tgcaccagtg gctcgaccgc ctcgcgccgc tgctcgacgg cacccgcacc ctcgaccggc
    15541 tcaccgcggg cctgcccgcc gaccgggccg cgttcgtcac caaactcgtc ggcgtcctcg
    15601 ccgagcgcgg cctggtgcgc atggtcggcc ccggcacgcc ggacacgctc accgacgccg
    15661 aacgccacga gtaccgcgga ctgctgtcct atctcggcta cttcagcgac tcacccggcc
    15721 acgtcctcga aaacgtcctc gacaccccga ccgtgatcat cggatcggac ccgctggcgg
    15781 ccgagctgag ccgcgcgtgc gccgccgcgg gactgcggaa ggtcgagatg gccgacgagg
    15841 tgggcaccgc ccaggtcgtg gtacacgtgg ccgaccgcgc cgaaccggag cgagccgtac
    15901 ggctggagcg gctctgcgcc gcgtccggag ccctgctggc gcaggtcatg cccgtggcgg
    15961 acggcatctg gtggcagccc gcggcccggg gcggtggctt ggcgagcgcc tggcgcaggc
    16021 accgggcact ggcaggtccg gtcccggcgg ccggccctcc ggacccggtg gcggccaagg
    16081 tggtggcgaa ccaggtggcg cacgacgtgt tccggctcct gaccggtctg cgcgaggaga
    16141 ccgcgccccg gctggtggtg ttcgacccgc ggaccatggc gagcaccacg catccgatca
    16201 ttccgcaccc gctcgacctg cccgccgaac cgctggacga ggccgcgttc ctcgaccgga
    16261 tcacctcgct gcgcaccgcc cccgcggtga gcgaggagga gttctcccgg cgggccaagg
    16321 ggctgatgga cgggagaacc ggactgttcg ccgagatcga cgagggcgat ctcgcgcagt
    16381 tgccgctgca cgtcacggcg accacggtgt cagacccgtg cgggagactg ggcgacgcgc
    16441 ccaggccggt ggtcaccggc gccggtttca ccttcgagga ggcccgctac cgggcggcgc
    16501 tcgcggccct ggcgcgcgcc ggcacgctga cgctcgacga acggcggctg atcgacggcc
    16561 acgtgcacgc ctacgacctg gtggaccaca cggcacgcct ggtgccggcg gagaccgtct
    16621 tcggcgcgtc gcgtggtgcc gcggcggcgt actcatggga cgaggcggtc gccgcgggcc
    16681 tgaccgccca cgcggccgcg ctcaccctcg acgggatcgc gcacgtcacc gagccgttcg
    16741 ggcgggtgga cctgacggag gcgccggagt actgcctggc gatgatccgc gcgctcggcg
    16801 agaagccggc cgtgtacgac gtcaccggac cgctgggtgc gcccacggtg gtcgggacgc
    16861 tctccggcgg ggccaccgcg tgcggtgcgg ccctgacgat cgaggccgcc gtggccgcat
    16921 gcctccgcga cctgctgctg gtccgccagg ccgagatcaa cgatcagccg gtctacgccc
    16981 cggcgccgtg cgcgcccccg tccccggcgc ttcaggggga tcacctggcg ccccggcggc
    17041 cgggcaccga tgtgcccacg ctcgtggcga gactggccga gcagggccgc cgtccgctgg
    17101 cggtgccgct cgaccacgac ccggccgtgc acgcggccct gcccttcgtc gtccaggtgg
    17161 tgtgctgatg atccgtgtgc cggacagcgg cgaactgacc gtcgcgctgg agaaaggccc
    17221 gaggctcccg gtccggacgg aactgggccg gatcaccgtc ggcccgctgg aacggccggg
    17281 cgtgccgggg tgccgggaat gcgtgcgcgt ccgggagagg cgcgtccagc ccgacgcccg
    17341 caaggccgaa gccgtgcgcg ccctgcacac cccggcagcg agtcagtggc tcaccccgct
    17401 cgccaccgac ctggtccaca ccctggtcgc gagcgaggcc gccgcgctgg cggccgacgc
    17461 ggagccccgg accgtgaacg ccgtgctgga gatcgacctg atgaccctgg agatcacccg
    17521 gcaccggttc ctgccggatc cgctgtgcgc gcactgcggg gacctgccgc cggacgcccc
    17581 ggcggagctc accctccggt cccggcgcaa gctcggcggc agcccgcgga ccagggagat
    17641 cgagctcgac gcgctcctgg agacctacgt ggacggccgg accggcatga tccgcccgct
    17701 gaagaccggc gtgcagggcg gtctcacggt ggcgagcgcg atgctgccga tccgcgcggg
    17761 caacggcctc gaaccgggcg tcggccgcac ccggaactac cgcgccagca agctcaccgc
    17821 cgtgctggag gcgctggaac gctacggcgg cgtgagtccc gggggccgcc gcacggtgat
    17881 caggtccgcc taccgcgaca tcgccggtga cgccgtccac cccgatgggt tcggcacgca
    17941 tccggaggag aactacgacc gtcccgactt cgagttccgc cggttcaccg aggacacggt
    18001 gtgccgatgg gtgtggggct actcgttcgc gcagtcgcgg cccgtcctgg tgccggagaa
    18061 tcaggtctac tactacgccc ggcacatgcc cgacggcgag aagccgttcg tcttcgaggt
    18121 ctccaacgga tgcgcgctcg gctcgtgtct ggaggaggcg atcctccacg gcctgctgga
    18181 ggtcgtcgaa cgcgacgcgt tcctgctcac ctggcatgcc cggcggcagg tcccggtgct
    18241 ggaccccgcg ctggcggccg acccggtgct gccgatgcag gtcgccgcga tcactgctga
    18301 gacgggacat cgggtgctgt gcttcgacac cacggcggaa cacggcatcc cgagcgtgtg
    18361 ggtcatggcg gtggacgccg aacgccgccc ggaccaaccc gccaccgccc acgccgccgg
    18421 ctcggcgctc acgctggaga aggccacgat gaacgccctc agcgaactgg gaccgctgct
    18481 ggcggatgtg atccgccgct acccgcagca gcgggagcgg gcgcaggcca tggtccgcga
    18541 cccggaggag gtcgtcacca tgcacgacca ctcgatcctc tacgccgcgc cggaggcggc
    18601 ggaccggctg gacttcctca tcggccgcgc cgacggcccg aaggtggggt tcggcacgga
    18661 ccggttcacc ggtgacgacc tcaccgcgga cctgcgggcc atgatcgatg cggtgctggc
    18721 ggccggaatg gacgtggtgg tggtcgacca gaccaccccc gagcacctgg cgggcggatt
    18781 ccgctgcgtg aaggtgctgg tgcccggcgc gttgccgatg acgttcggcc atcggcaccg
    18841 gcggctggga aacctgccgc ggctggagac cgtacggacc accgatccgc acccgttccc
    18901 gtgagcagga aggatccgcc atgtacgtgg tgatcgtcgc gttcgacctg aaggactccg
    18961 ccatcgactt cgccgaactg cgcgcctggg tgcacgaccg ggcggcggac gattactcca
    19021 ggctgccggg gatgcgcttc aaggcgtggt tctccgacga gaggaaacgg ctgtggggcg
    19081 cggtctacct ggtggagtcg atgtcgtcgt tcgaccggga caagatcccg ctgctgcccg
    19141 acggagccac cggaccggtc ggcacccggc cgacctcgat catgttcctg gaacttgagg
    19201 cgttcgtcgc cggacccgac ggtatcgccg ggatcgaagc gctcacccgg caggggctga
    19261 gcatggtggg aggcagtcat gaccactgaa gcgatcacaa acgcacttcc gctgaccggg
    19321 ccgaagacgg acgagccgtt gctgctctac gtcaacgtcc cgttctgcaa ctccaaatgc
    19381 cacttctgcg actgggtggt ggacgtcccg gtctccgacc tgcggctcac tcccgtgtca
    19441 gcgggccgga tcgactacct ggaggcgctg cgcacccaga tccgcatcca cgcccccgcc
    19501 ctgcgggagg ccggttaccg cagcgaggtc atgtactggg gcgggggcac ggcgaccgtt
    19561 ctcaccgaac gggagatcga gcagacctac gcgtgcctgg cggcggagct cgacctgtcc
    19621 tccctggccg aggcgacgat cgaaggcagt cccgagtcgg tggacctcgc caagctgacg
    19681 ttcatgcgcg acctcggctt cgaccgggtg agcctcggcg tgcagtcgtt cgacgagacg
    19741 aggctgcgcc gcatcggccg cgcgcactcc gcgggccagg ccgtgcagag cgtcgaggcc
    19801 gcgcacgcgg cggggttcga caacatcaac atcgatctga tcgtcggttt cccggaccag
    19861 tcactggagg aggtcgagga gatgatccgg cgggcgctcg acctgccggt gaaccacttc
    19921 tcggtctact cgtaccgggc gaccgagggc acggtgatgc gcaagcagat cgagcgcagc
    19981 ggtaccgaga tcctgctgga gcatcagctg cggtcgtacc ggctcgccgc ggacatgctg
    20041 gccgcggcgg ggcaccccga gtacgcggtc tcgtacttcg gcgtgccgag gtgcctcgca
    20101 gacgaggcgt actaccggct cagcatggac tggatcggct tcgggacggg cgccaactcg
    20161 ctgatcaatc agcgctacct gctgaacggc cgcggccgga tgcgggactt caccagcaag
    20221 ccgggggagt tcgaggtgaa cctgccggcc gccaccggat cgctcaccgt gcaatggctg
    20281 cccagggcgc tgggcacctc ggaggggatc gacgcggtca ccttccagcg ccgcaccggc
    20341 atgtcgttac gcgcggcgtg cgaggagccc gacctgaacg cgttcctgag gcaggtcaac
    20401 aggttcggcg atctggtggt ggaccgcacc ggcatccgcc tcgcggacga cgaccggtcg
    20461 agcgtgctgt cccgtacgtt cgccgcgatg ggctgggtgt cctgagtgga ggcgatgcgc
    20521 acggtgctcg ccgccgcgga cctggcgacg cccatggccg tccgggtcgc ggcgacgctg
    20581 aggctggccg accgcatcgc ggccggaacg gattccgcgg ccgcactcgc cgcggccgcg
    20641 ggggccgatg aggcggcact gacgcggttg ctgcgctacc tggtcgcgcg ggacatcttc
    20701 cgcgaaccgt caccggggcg tttcgccctg agcccggccg cggagctgct gcgcggcgac
    20761 cgcccggagc ggttgcgcga ctggctggac ctcaccggcc cgatcggccg cgcggacctg
    20821 gcgttcgggt cgctgctgga cgtcgtgctc accggcaggc ccggataccc gatgatccat
    20881 ggacggggct tctgggacga cctcgccggc cggcccgagc tcgccgccgc gtacgacgcc
    20941 ctgatgggcg gcaagcgcga ctgggcggcg accaccctcg ccgcgctcga ctggagccgt
    21001 tcccggcatg tggtggacgt cggcggcggc aacggcaccc tgctgtcgtg tgtcctggcc
    21061 gcgcatcggc atctgcgcgg cactgtcgtg gaccggccct cgtccgccga ggccgccggg
    21121 gcggtgctgg cgtcggcggg cgttgcggac cgctgcgagt tccgggcggg ggacttcttc
    21181 gaaccgttgc cggtgaaggg tgccgacacc tatctgctga gttcgatcgt gcacgactgg
    21241 gacgactcct cggcggtcgc gatcctgcgc cgctgcgcgg aggccgccgg gccgggcggc
    21301 cggatactgc tgtgtgagct gatggccgga ggcgggcggg accagcgggc ggtgacacag
    21361 atggacctgt gcatgctcgt gtacttcggc gggcgggaac gcaccgggga cgagttcgcc
    21421 gcgctggccg agcgtgccgg actggaactg cggacggtga cgccgctgcc gccgcatgac
    21481 tggggcaact cgctcatcga gtgcgtggtc accgggggct ga
//
