Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001156.1:
Cluster 1Terpene135788

BGC0001156, platencin biosynthetic gene cluster from Streptomyces platensis. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Platencin
PubChem ID: 44450228
SMILES string: Copy to clipboard
Molecular formula: C24H27NO6
Average molecular mass: 425.481 Da
Molecular activity: Antibacterial
Molecular target: FabF, FabH

Class-specific details

Biosynthetic class(es):
Terpene
Terpene subclass:
Other
Terpene subclass by size:
Diterpene
Final isoprenoid precursor:
GGPP
Terpene synthase/cyclase-encoding genes:
ADD83014, ADD83004
Prenyltransferase-encoding genes:
ADD83016

Gene cluster description

platencin (BGC0001156). Gene Cluster 1. Biosynthetic class = Terpene. GenBank GQ398492, positions 2500-38300. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies, Heterologous expression, Sequence-based prediction
MIxS-compliance:Unknown
Contact for this cluster:Michael Smanski (University of Minnesota)

Literature references

1. Yu Z et al. (2010) Engineering of Streptomyces platensis MA7339 for overproduction of platencin and congeners. Org Lett 12(8):1744-7. doi: 10.1021/ol100342m.
2. Smanski MJ et al. (2011) Dedicated ent-kaurene and ent-atiserene synthases for platensimycin and platencin biosynthesis. Proc Natl Acad Sci U S A 108(33):13498-503. doi:
3. Smanski MJ et al. (2012) Expression of the platencin biosynthetic gene cluster in heterologous hosts yielding new platencin congeners. J Nat Prod 75(12):2158-67. doi: 10.1021/np3005985. Epub 2012 Nov 16.