BGC0001159: marinopyrrole A biosynthetic gene cluster from Streptomyces sp. CNQ-418
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Location: 1 - 43,083 nt. (total: 43,083 nt).
This entry is originally from NCBI GenBank JX157625.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001159
Short description marinopyrrole A biosynthetic gene cluster from Streptomyces sp. CNQ-418
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Type I)
Loci
JX157625.1
via Knock-out studies, Heterologous expression
Compounds
  • marinopyrrole A
  • marinopyrrole E
  • marinopyrrole D
  • marinopyrrole C
  • marinopyrrole B
Species Streptomyces sp. CNQ-418 [taxonomy]
References
Chemical products information
marinopyrrole A Evidence:
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C22H12Cl4N2O4
Chemical database entries
NPAtlas
marinopyrrole E Evidence:
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C22H11Br1Cl4N2O4
Chemical database entries
NPAtlas
marinopyrrole D Evidence:
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C22H11Cl5N2O4
Chemical database entries
NPAtlas
marinopyrrole C Evidence:
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C22H11Cl5N2O4
Chemical database entries
NPAtlas
marinopyrrole B Evidence:
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C22H11Br1Cl4N2O4
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AFP87514.1
 10 - 540 (-) chloramphenicol 3-O-phosphotransferase
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    • AFP87515.1
    		 1003 - 1686 (+) hypothetical protein
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      • AFP87516.1
      		 1790 - 3760 (-) hsp90-like protein
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        • AFP87517.1
        		 4167 - 5111 (+) oxidoreductase
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          • AFP87518.1
          • mpy1
          		 5310 - 5858 (-) flavin reductase
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            • AFP87519.1
            • mpy2
            		 5855 - 7486 (-) proline adenyltransferase
            • Precursor biosynthesis
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            • AFP87520.1
            • mpy3
            		 7483 - 8622 (-) acyl-CoA dehydrogenase
            • Precursor biosynthesis
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            • AFP87521.1
            • mpy4
            		 8664 - 10034 (-) sodium/hydrogen exchanger
            • Transport
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            • AFP87522.1
            • mpy5
            		 10031 - 11785 (-) FADH2-dependent halogenase
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              • AFP87523.1
              • mpy6
              		 11817 - 18584 (-) type I polyketide synthase
              • Scaffold biosynthesis
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              • AFP87524.1
              • mpy7
              		 18581 - 25324 (-) type I polyketide synthase
              • Scaffold biosynthesis
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              • AFP87525.1
              • mpy8
              		 25414 - 26448 (+) 4'-phosphopantetheinyl transferase
              • Activation / processing
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              • AFP87526.1
              • mpy9
              		 26451 - 27299 (+) type II thioesterase
              • Activation / processing
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              • AFP87527.1
              • mpy10
              		 27470 - 29218 (+) FADH2-dependent halogenase
              • Tailoring
              • Knock-out
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              • AFP87528.1
              • mpy11
              		 29258 - 30928 (+) FADH2-dependent halogenase
              • Tailoring
              • Knock-out
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              • AFP87529.1
              • mpy12
              		 30954 - 31694 (+) ABC transporter
              • Transport
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              • AFP87530.1
              • mpy13
              		 31744 - 32481 (+) ABC transporter
              • Transport
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              • AFP87531.1
              • mpy14
              		 32513 - 33253 (+) ABC transporter
              • Transport
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              • AFP87532.1
              • mpy15
              		 33367 - 33633 (+) proline carrier protein
              • Activation / processing
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              • AFP87533.1
              • mpy16
              		 33648 - 34991 (+) FADH2-dependent halogenase
              • Precursor biosynthesis
              • Knock-out
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              • AFP87534.1
              		 35095 - 36966 (+) 2-oxoglutarate ferredoxin oxidoreductase, alpha subunit
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                • AFP87535.1
                		 36950 - 38041 (+) 2-oxoglutarate ferredoxin oxidoreductase, beta subunit
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                  • AFP87536.1
                  		 38253 - 38882 (-) TetR family transcriptional regulator
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                    • AFP87537.1
                    		 39320 - 41113 (-) hypothetical protein
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                      • AFP87538.1
                      		 41838 - 43067 (+) transposase
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                        Biosynthesis information

                        Biosynthetic modules

                        Name
                        1
                        Type
                        pks-modular
                        Genes
                        mpy7
                        Substrates
                        Integrated Monomers
                        Domains
                        acyltransferase, ketosynthase, acyltransferase, carrier (ACP)
                        Name
                        2
                        Type
                        pks-modular
                        Genes
                        mpy7
                        Substrates
                        Integrated Monomers
                        Domains
                        acyltransferase, ketosynthase, acyltransferase, carrier (ACP)
                        Name
                        3
                        Type
                        pks-modular
                        Genes
                        mpy6
                        Substrates
                        Integrated Monomers
                        Domains
                        acyltransferase, ketosynthase, acyltransferase, ketoreductase, thioesterase, carrier (ACP)
                        Annotation changelog

                        Entry version: 4

                        Date
                        Changes
                        Submitters
                        Reviewers
                        2022-10-07
                        Update chemical activity to schema version 2.11
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                        Entry version: 3

                        Date
                        Changes
                        Submitters
                        Reviewers
                        2022-09-15
                        Removed ketoreductase stereochemistry annotation from modules without ketoreductases
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        2022-09-15
                        Updated bioactivity data
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                        Entry version: 2

                        Date
                        Changes
                        Submitters
                        Reviewers
                        2019-10-16
                        Migrated from v1.4
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        2019-10-16
                        Updated compound(s) information (NPAtlas curation)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                        Entry version: 1

                        Date
                        Changes
                        Submitters
                        Reviewers
                        2015-06-12
                        Submitted
                        • (ID: UJYWT4SZRXDY2IOPYAIF6MII)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        Detailed domain annotation
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