BGC0001159 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001159 (Streptomyces sp. CNQ-418)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	43,083	marinopyrrole A/marinopyrrole E/marinopyrrole D/marinopyrrole C/marinopyrrole B	NRPS:Type I+PKS:Type I	100%

BGC0001159 - Region 1 - T1PKS

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Location: 1 - 43,083 nt. (total: 43,083 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 43,084
Label		BGC0001159

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001159	1.00	NRP, Polyketide	marinopyrrole A, marinopyrrole E, marinopyrrole D, marinopyrrole C, marinopyrrole B	Streptomyces sp. CNQ-418
BGC0002341	0.32	Other	3,5-dibromo-p-anisic acid	Planctomycetales bacterium 10988
BGC0000131	0.32	Polyketide	pyrrolomycin	Streptomyces sp. UC 11065
BGC0000924	0.29	Other	pyrrolnitrin	Pseudomonas chlororaphis
BGC0001925	0.29	Alkaloid	altemicidin, SB-203207, SB-203208	Streptomyces sp.
BGC0000840	0.28	Other	xanthomonadin I	Xanthomonas oryzae pv. oryzae
BGC0002443	0.27	Polyketide	mycemycin C, mycemycin A, mycemycin B	Streptomyces olivaceus
BGC0001778	0.26	Other	showdomycin	Streptomyces showdoensis
BGC0001264	0.26	Polyketide	betaenone A, betaenone B, betaenone C	Phoma betae
BGC0000837	0.25	Other	APE Vf	Aliivibrio fischeri ES114

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001159	1.00	NRP, Polyketide	marinopyrrole A, marinopyrrole E, marinopyrrole D, marinopyrrole C, marinopyrrole B	Streptomyces sp. CNQ-418
BGC0002341	0.65	Other	3,5-dibromo-p-anisic acid	Planctomycetales bacterium 10988
BGC0000131	0.65	Polyketide	pyrrolomycin	Streptomyces sp. UC 11065
BGC0000924	0.63	Other	pyrrolnitrin	Pseudomonas chlororaphis
BGC0001925	0.62	Alkaloid	altemicidin, SB-203207, SB-203208	Streptomyces sp.
BGC0000840	0.61	Other	xanthomonadin I	Xanthomonas oryzae pv. oryzae
BGC0002443	0.60	Polyketide	mycemycin C, mycemycin A, mycemycin B	Streptomyces olivaceus
BGC0001778	0.59	Other	showdomycin	Streptomyces showdoensis
BGC0001264	0.59	Polyketide	betaenone A, betaenone B, betaenone C	Phoma betae
BGC0000837	0.58	Other	APE Vf	Aliivibrio fischeri ES114

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 43083:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (pk) + (ohmal)
Non-colinear ordering:: mpy7 + mpy6

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

mpy2

Search NORINE for peptide: strict or relaxed

AMP-binding (8..445): Pro

nrpys: Pro

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DLFYVAWVCK
Nearest Stachelhaus code(s):: Pro DLFYVAWVCK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

mpy6

PKS_AT (574..868): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 79.2%; Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 182.3
inactive: 91.8
Methoxymalonyl-CoA: 78.0
Methylmalonyl-CoA: 70.6
Isobutyryl-CoA: 52.4
Propionyl-CoA: 48.9
Ethylmalonyl-CoA: 32.3
trans-1,2-CPDA: 17.2
Acetyl-CoA: 16.9
Benzoyl-CoA: 14.0
fatty_acid: 13.8
CHC-CoA: 13.1
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: -2.4

mpy7

PKS_AT (554..850): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 66.7%; Methylmalonyl-CoA: 58.3%; Propionyl-CoA: 54.2%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 94.6
Malonyl-CoA: 91.3
Methoxymalonyl-CoA: 78.4
Propionyl-CoA: 54.2
inactive: 43.1
Ethylmalonyl-CoA: 39.4
trans-1,2-CPDA: 29.4
Isobutyryl-CoA: 24.2
2-Methylbutyryl-CoA: 24.0
Benzoyl-CoA: 21.9
Acetyl-CoA: 18.7
CHC-CoA: 16.1
fatty_acid: 12.6
3-Methylbutyryl-CoA: -0.1