Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001166.1:
Cluster 1NRP115624

BGC0001166, HC-toxin biosynthetic gene cluster from Alternaria jesenskae. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: HC-toxin
PubChem ID: 107864
SMILES string: Copy to clipboard
Molecular formula: C21H32N4O6
Average molecular mass: 436.509 Da
Molecular activity: Inhibitor
Molecular target: histone deacetylase RPD3-class

Class-specific details

Biosynthetic class(es):
NRP
Other (cyclic)
Thioesterase type:
Unknown
Release / cyclization type:
Macrolactamization

Nonribosomal peptide synthetases:
HTS1 (AGQ43600.1)
Module 1
A specificity: Proline
Evidence for specificity: Sequence-based prediction
AA is epimerized
C domain subtype: Other
Scaffold-modifying domain: Other
Module 2
A specificity: Alanine
Evidence for specificity: Sequence-based prediction
C domain subtype: Other
Module 3
A specificity: D-Alanine
Evidence for specificity: Sequence-based prediction
C domain subtype: Other
Module 4
A specificity: 2-amino-9,10-epoxi-8-oxodecanoic acid
Evidence for specificity: Sequence-based prediction
C domain subtype: Other

Gene cluster description

HC-toxin (BGC0001166). Gene Cluster 1. Biosynthetic class = NRP. GenBank KC862269. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

General MIBiG information on this cluster

Complete gene cluster sequence?incomplete
Evidence for cluster-compound connection:Sequence-based prediction
MIxS-compliance:Unknown
Contact for this cluster:Jonathan Walton (Michigan State University)

Literature references

1. Wight WD et al. (2013) Conservation of the genes for HC-toxin biosynthesis in Alternaria jesenskae. BMC Microbiol 13:165. doi: 10.1186/1471-2180-13-165.