Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001169.1:
Cluster 1Polyketide149160

BGC0001169, piericidin A1 biosynthetic gene cluster from Streptomyces sp. SCSIO. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: piericidin A1
PubChem ID: 6437838
SMILES string: Copy to clipboard
Molecular formula: C25H37NO4
Average molecular mass: 415.574 Da
Molecular activity: Unknown

Class-specific details

Biosynthetic class(es):
Polyketide
Polyketide subclass:
Polyene (linear)
Polyketide synthase subclass:
Modular type I
Starter unit:
Malonyl-CoA
Thioesterase type:
Unknown
Release / cyclization type:
None

Modular polyketide synthases:
pieA1
Module 1
AT specificity: Methylmalonyl-CoA
Evidence for specificity: Unknown
Module 0
AT specificity: Malonyl-CoA
Evidence for specificity: Unknown

pieA2
Module 2
AT specificity: Methylmalonyl-CoA
Evidence for specificity: Unknown
Module 3
AT specificity: Methylmalonyl-CoA
Evidence for specificity: Unknown

pieA3
Module 4
AT specificity: Malonyl-CoA
Evidence for specificity: Unknown

pieA4
Module 5
AT specificity: Methylmalonyl-CoA
Evidence for specificity: Unknown

pieA5
Module 6
AT specificity: None
Evidence for specificity: Unknown

pieA6
Module 7
AT specificity: Methylmalonyl-CoA
Evidence for specificity: Unknown
Module 8
AT specificity: Methylmalonyl-CoA
Evidence for specificity: Unknown

Gene cluster description

piericidin A1 (BGC0001169). Gene Cluster 1. Biosynthetic class = Polyketide. GenBank KF874660, positions 1-49160. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies, Enzymatic assays, Sequence-based prediction
MIxS-compliance:Unknown
Contact for this cluster:Changsheng Zhang (South China Sea Institute of Oceanology, Chinese Academy of Sciences)

Literature references

1. Chen Y et al. (2014) Elucidating hydroxylation and methylation steps tailoring piericidin A1 biosynthesis. Org Lett 16(3):736-9. doi: 10.1021/ol4034176. Epub 2014 Jan 10.