Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001170.1:
Cluster 1RiPP18486

BGC0001170, clostridiolysin S biosynthetic gene cluster from Clostridium sporogenes. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Clostridiolysin S
Molecular activity: Cytotoxic

Class-specific details

Biosynthetic class(es):
RiPP
RiPP subclass:
LAP (linear)
Peptides in this cluster:
CLOSPO_01168
RiPP core peptide sequence(s): SCCCCSCCCCVSVSVGGGSASTGGGAAAGQGGN
Leader peptide length: 24
Follower peptide length: -1
Peptidase(s) involved in precursor cleavage: clospo_01172

Gene cluster description

clostridiolysin S (BGC0001170). Gene Cluster 1. Biosynthetic class = RiPP. GenBank NZ_DS981518, positions 691338-699823. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies, Enzymatic assays, Sequence-based prediction
MIxS-compliance:Unknown
Contact for this cluster:Professor Douglas Mitchell (University of Illinois at Urbana-Champaign)

Literature references

1. Lee SW et al. (2008) Discovery of a widely distributed toxin biosynthetic gene cluster. Proc Natl Acad Sci U S A 105(15):5879-84. doi:
2. Mitchell DA et al. (2009) Structural and functional dissection of the heterocyclic peptide cytotoxin streptolysin S. J Biol Chem 284(19):13004-12. doi: 10.1074/jbc.M900802200. Epub 2009
3. Gonzalez DJ et al. (2010) Clostridiolysin S, a post-translationally modified biotoxin from Clostridium botulinum. J Biol Chem 285(36):28220-8. doi: 10.1074/jbc.M110.118554. Epub 2010
4. Molloy EM et al. (2011) Streptolysin S-like virulence factors: the continuing sagA. Nat Rev Microbiol 9(9):670-81. doi: 10.1038/nrmicro2624.