Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001172.1:
Cluster 1NRP / Polyketide142435

BGC0001172, chlorizidine A biosynthetic gene cluster from Streptomyces sp. CNH-287. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Chlorizidine A
SMILES string: Copy to clipboard
Molecular formula: C18H10Cl4N2O3
Exact molecular mass: 444.0956 Da (Molecular ion)
Molecular activity: Cytotoxic

Class-specific details

Biosynthetic class(es):
NRP / Polyketide
Other (cyclic)
Thioesterase type:
Type II
Release / cyclization type:
Other

Polyketide subclass:
Other (cyclic)
Polyketide synthase subclass:
Modular type I
Starter unit:
Other
Thioesterase type:
None
Release / cyclization type:
Other

Modular polyketide synthases:
clz6 (AHA12078.1)
Module 1
AT specificity: Malonyl-CoA
Evidence for specificity: Unknown
Module 2
AT specificity: Methylmalonyl-CoA
Evidence for specificity: Unknown

clz7 (AHA12079.1)
Module 3
AT specificity: Malonyl-CoA
Evidence for specificity: Unknown

Gene cluster description

chlorizidine A (BGC0001172). Gene Cluster 1. Biosynthetic class = NRP/Polyketide. GenBank KF585133. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies, Enzymatic assays, Heterologous expression
MIxS-compliance:Unknown
Contact for this cluster:Simone Moraes Mantovani (University of California San Diego)

Literature references

1. Mantovani SM, Moore BS. (2013) Flavin-linked oxidase catalyzes pyrrolizine formation of dichloropyrrole-containing polyketide extender unit in chlorizidine A. J Am Chem Soc 135(48):18032-5. doi: 10.1021/ja409520v. Epub 2013 Nov
2. Alvarez-Mico X et al. (2013) Chlorizidine, a cytotoxic 5H-pyrrolo[2,1-a]isoindol-5-one-containing alkaloid from a marine Streptomyces sp. Org Lett 15(5):988-91. doi: 10.1021/ol303374e. Epub 2013 Feb 13.