BGC0001172: chlorizidine A biosynthetic gene cluster from Streptomyces sp. CNH-287
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Location: 1 - 42,435 nt. (total: 42,435 nt).
This entry is originally from NCBI GenBank KF585133.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001172
Short description chlorizidine A biosynthetic gene cluster from Streptomyces sp. CNH-287
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Type I)
Loci
KF585133.1
via Knock-out studies, Enzymatic assays, Heterologous expression
Compounds
  • chlorizidine A
Species Streptomyces sp. CNH-287 [taxonomy]
References
Chemical products information
chlorizidine A Evidence:
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C18H10Cl4N2O3
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AHA12073.1
  • clz1
 38 - 1588 (-) sugar kinase
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    • AHA12074.1
    • clz2
    		 1743 - 2318 (-) putative sterol carrier protein
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      • AHA12075.1
      • clz3
      		 2346 - 3143 (+) enoyl-acyl carrier protein reductase
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        • AHA12076.1
        • clz4
        		 3301 - 4482 (+) crotonyl-CoA carboxylase reductase
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          • AHA12077.1
          • clz5
          		 4499 - 5845 (+) flavin-dependent halogenase
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            • AHA12078.1
            • clz6
            		 5891 - 14785 (+) polyketide synthase type 1
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              • AHA12079.1
              • clz7
              		 14782 - 19080 (+) polyketide synthase type 1
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                • AHA12080.1
                • clz8
                		 19077 - 20714 (+) flavin-dependent halogenase
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                  • AHA12081.1
                  • clz9
                  		 20711 - 22231 (+) flavin-dependent oxidase
                  • Tailoring
                  • Knock-out Activity assay
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                  • AHA12082.1
                  • clz10
                  		 22334 - 22588 (+) acyl carrier protein
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                    • AHA12083.1
                    • clz11
                    		 22585 - 23868 (+) 3-oxoacyl-acyl carrier protein synthase
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                      • AHA12084.1
                      • clz12
                      		 24163 - 24828 (+) transcriptional regulator
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                        • AHA12085.1
                        • clz13
                        		 25283 - 25915 (+) transcriptional regulator
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                          • AHA12086.1
                          • clz14
                          		 26027 - 27490 (-) amino acid adenyltransferase
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                            • AHA12087.1
                            • clz15
                            		 27487 - 28626 (-) acyl-CoA dehydrogenase
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                              • AHA12088.1
                              • clz16
                              		 29241 - 30584 (+) Na/H exchanger
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                                • AHA12089.1
                                • clz17
                                		 30581 - 31387 (+) phosphopantetheinyl transferase
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                                  • AHA12090.1
                                  • clz18
                                  		 31415 - 31705 (+) L-proline carrier protein
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                                    • AHA12091.1
                                    • clz19
                                    		 32032 - 32736 (+) transcriptional regulator
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                                      • AHA12092.1
                                      • clz20
                                      		 32720 - 33343 (+) transcriptional regulator
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                                        • AHA12093.1
                                        • clz21
                                        		 33394 - 34113 (+) thioesterase
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                                          • AHA12094.1
                                          • clz22
                                          		 34250 - 35128 (-) trypsin-like protease
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                                            • AHA12095.1
                                            • clz23
                                            		 35227 - 36741 (-) transporter
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                                              • AHA12096.1
                                              • clz24
                                              		 36838 - 37434 (-) NADPH-dependent FMN reductase
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                                                • AHA12097.1
                                                • clz25
                                                		 37562 - 38299 (+) transcriptional regulator
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                                                  • AHA12098.1
                                                  • clz26
                                                  		 38399 - 38869 (+) transposase
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                                                    Biosynthesis information

                                                    Biosynthetic modules

                                                    Name
                                                    1
                                                    Type
                                                    pks-modular
                                                    Genes
                                                    clz6
                                                    Substrates
                                                    Integrated Monomers
                                                    Domains
                                                    acyltransferase, ketosynthase, acyltransferase, carrier (ACP)
                                                    Name
                                                    2
                                                    Type
                                                    pks-modular
                                                    Genes
                                                    clz6
                                                    Substrates
                                                    Integrated Monomers
                                                    Domains
                                                    acyltransferase, ketosynthase, acyltransferase, carrier (ACP)
                                                    Name
                                                    3
                                                    Type
                                                    pks-modular
                                                    Genes
                                                    clz7
                                                    Substrates
                                                    Integrated Monomers
                                                    Domains
                                                    acyltransferase, ketosynthase, acyltransferase, carrier (ACP)
                                                    Annotation changelog

                                                    Entry version: 4

                                                    Date
                                                    Changes
                                                    Submitters
                                                    Reviewers
                                                    2022-10-07
                                                    Update chemical activity to schema version 2.11
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                    Entry version: 3

                                                    Date
                                                    Changes
                                                    Submitters
                                                    Reviewers
                                                    2022-09-15
                                                    Removed ketoreductase stereochemistry annotation from modules without ketoreductases
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                    Entry version: 2

                                                    Date
                                                    Changes
                                                    Submitters
                                                    Reviewers
                                                    2019-10-16
                                                    Migrated from v1.4
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    2019-10-16
                                                    Updated compound(s) information (NPAtlas curation)
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                    Entry version: 1

                                                    Date
                                                    Changes
                                                    Submitters
                                                    Reviewers
                                                    2015-06-12
                                                    Submitted
                                                    • (ID: N52IJH5LHPQ7BFWMKQOBW6U7)
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    Detailed domain annotation
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