BGC0001172: chlorizidine A biosynthetic gene cluster from Streptomyces sp. CNH-287
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Location: 1 - 42,435 nt. (total: 42,435 nt).
This entry is originally from NCBI GenBank KF585133.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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resistance
TTA codons
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Gene details
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General
Compounds
Genes
Polyketide
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001172
Short description chlorizidine A biosynthetic gene cluster from Streptomyces sp. CNH-287
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide (Other)
Loci NCBI GenBank: KF585133.1
Compounds
  • chlorizidine A
Species Streptomyces sp. CNH-287 [taxonomy]
References
Chemical products information
chlorizidine A
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C18H10Cl4N2O3
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AHA12073.1
  • clz1
 38 - 1588 (-) sugar kinase
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  • AHA12074.1
  • clz2
 1743 - 2318 (-) putative sterol carrier protein
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  • AHA12075.1
  • clz3
 2346 - 3143 (+) enoyl-acyl carrier protein reductase
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  • AHA12076.1
  • clz4
 3301 - 4482 (+) crotonyl-CoA carboxylase reductase
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  • AHA12077.1
  • clz5
 4499 - 5845 (+) flavin-dependent halogenase
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  • AHA12078.1
  • clz6
 5891 - 14785 (+) polyketide synthase type 1
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  • AHA12079.1
  • clz7
 14782 - 19080 (+) polyketide synthase type 1
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  • AHA12080.1
  • clz8
 19077 - 20714 (+) flavin-dependent halogenase
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  • AHA12081.1
  • clz9
 20711 - 22231 (+) flavin-dependent oxidase
  • Tailoring (Oxidation)
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  • AHA12082.1
  • clz10
 22334 - 22588 (+) acyl carrier protein
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  • AHA12083.1
  • clz11
 22585 - 23868 (+) 3-oxoacyl-acyl carrier protein synthase
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  • AHA12084.1
  • clz12
 24163 - 24828 (+) transcriptional regulator
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  • AHA12085.1
  • clz13
 25283 - 25915 (+) transcriptional regulator
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  • AHA12086.1
  • clz14
 26027 - 27490 (-) amino acid adenyltransferase
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  • AHA12087.1
  • clz15
 27487 - 28626 (-) acyl-CoA dehydrogenase
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  • AHA12088.1
  • clz16
 29241 - 30584 (+) Na/H exchanger
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  • AHA12089.1
  • clz17
 30581 - 31387 (+) phosphopantetheinyl transferase
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  • AHA12090.1
  • clz18
 31415 - 31705 (+) L-proline carrier protein
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  • AHA12091.1
  • clz19
 32032 - 32736 (+) transcriptional regulator
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  • AHA12092.1
  • clz20
 32720 - 33343 (+) transcriptional regulator
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  • AHA12093.1
  • clz21
 33394 - 34113 (+) thioesterase
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  • AHA12094.1
  • clz22
 34250 - 35128 (-) trypsin-like protease
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  • AHA12095.1
  • clz23
 35227 - 36741 (-) transporter
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  • AHA12096.1
  • clz24
 36838 - 37434 (-) NADPH-dependent FMN reductase
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  • AHA12097.1
  • clz25
 37562 - 38299 (+) transcriptional regulator
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  • AHA12098.1
  • clz26
 38399 - 38869 (+) transposase
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Polyketide-specific information
Subclass Other
Cyclic? yes
Polyketide-synthases
Genes Properties Modules
clz7
+
clz6 		Synthase subclass: Modular type I
Module 1
Specificity: Malonyl-CoA
Genes: clz6
Core domains: Ketosynthase, Acyltransferase, Thiolation (ACP/PCP)
Module 2
Specificity: Methylmalonyl-CoA
Genes: clz6
Core domains: Ketosynthase, Acyltransferase, Thiolation (ACP/PCP)
Module 3
Specificity: Malonyl-CoA
Genes: clz7
Core domains: Ketosynthase, Acyltransferase, Thiolation (ACP/PCP)
NRP-specific information
Subclass N/A
Cyclic? yes
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: N52IJH5LHPQ7BFWMKQOBW6U7, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Removed ketoreductase stereochemistry annotation from modules without ketoreductases
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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