Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001173.1:
Cluster 1RiPP19945

BGC0001173, plantazolicin biosynthetic gene cluster from Bacillus pumilus. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: plantazolicin
ChemSpider ID: 28419936
SMILES string: Copy to clipboard
Molecular formula:
Average molecular mass: Da
Molecular activity: Antibacterial

Class-specific details

Biosynthetic class(es):
RiPP
RiPP subclass:
LAP (linear)
Peptides in this cluster:
BAT_4209
RiPP core peptide sequence(s): RCTCTTIISSSSTF
Leader peptide length: 27
Follower peptide length: -1
Peptidase(s) involved in precursor cleavage: bat_2466

Gene cluster description

plantazolicin (BGC0001173). Gene Cluster 1. Biosynthetic class = RiPP. GenBank NZ_ABRX01000001, positions 223361-233305. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Enzymatic assays, Proven expression in natural host, Sequence-based prediction
MIxS-compliance:Unknown
Contact for this cluster:Doug Mitchell, Rainer Borriss (University of Illinois at Urbana-Champaign, Humboldt University Berlin)

Literature references

1. Molohon KJ et al. (2011) Structure determination and interception of biosynthetic intermediates for the plantazolicin class of highly discriminating antibiotics. ACS Chem Biol 6(12):1307-13. doi: 10.1021/cb200339d. Epub 2011 Oct
2. Lee J et al. (2013) Structural and functional insight into an unexpectedly selective N-methyltransferase involved in plantazolicin biosynthesis. Proc Natl Acad Sci U S A 110(32):12954-9. doi:
3. Liu Z et al. (2013) The highly modified microcin peptide plantazolicin is associated with nematicidal activity of Bacillus amyloliquefaciens FZB42. Appl Microbiol Biotechnol 97(23):10081-90. doi: