Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001176.1:
Cluster 1RiPP14792

BGC0001176, streptomonomicin biosynthetic gene cluster from Streptomonospora alba. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Streptomonomicin
SMILES string: Copy to clipboard
Molecular formula: C107H160N22O30
Exact molecular mass: 2256.15684 Da ([M+Na]+)
Molecular activity: Antibacterial

Class-specific details

Biosynthetic class(es):
RiPP
RiPP subclass:
Lassopeptide (cyclic)
Peptides in this cluster:
LP52_05076
RiPP core peptide sequence(s): SLGSSPYNDILGYPALIVIYP
Leader peptide length: 20
Follower peptide length: 21
Peptidase(s) involved in precursor cleavage:

Gene cluster description

streptomonomicin (BGC0001176). Gene Cluster 1. Biosynthetic class = RiPP. GenBank JROO01000009, positions 9271-14062. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Sequence-based prediction
MIxS-compliance:Unknown
Comments:Streptomonomicin is a lasso peptide from Streptomonospora alba with a unique Ser1-Asp9 linkage. Streptomonomicin exhibits antibiotic activity against Gram-positive bacteria, particularly the genus Bacillus.
Contact for this cluster:Douglas A. Mitchell (University of Illinois at Urbana-Champaign)

Literature references

1. Metelev M et al. (2015) Structure, bioactivity, and resistance mechanism of streptomonomicin, an unusual lasso Peptide from an understudied halophilic actinomycete. Chem Biol 22(2):241-50. doi: 10.1016/j.chembiol.2014.11.017. Epub