BGC0001177 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001177 (Streptomyces bottropensis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T2PKS	1	36,742	High	mensacaricin	PKS:Type II

BGC0001177 - Region 1 - T2PKS

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Location: 1 - 36,742 nt. (total: 36,742 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 36,743
Label		BGC0001177

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase

msnO1: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

msnO10: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

msnO11: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

msnO3: flavin reductase domain protein FMN-binding

smcogs: SMCOG1160: flavin reductase domain protein FMN-binding

msnO9: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

Lyases: cyclase

msnC1: cyclase/dehydrase

smcogs: SMCOG1128: cyclase/dehydrase

msnC3: cyclase/dehydrase

smcogs: SMCOG1128: cyclase/dehydrase

Ligases: synthase

msnK1: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

msnK2: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001177.4	1.00	PKS	mensacaricin	Streptomyces bottropensis
BGC0000231.5	0.73	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000234.5	0.64	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000272.3	0.61	PKS	spore pigment	Streptomyces collinus
BGC0001723.5	0.61	PKS	oviedomycin	Streptomyces antibioticus
BGC0002276.2	0.59	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0001197.5	0.58	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0000271.5	0.56	PKS	spore pigment	Streptomyces avermitilis
BGC0000218.5	0.54	PKS	doxorubicin	Streptomyces peucetius
BGC0002000.4	0.54	PKS	setomimycin	Streptomyces aurantiacus JA 4570

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001177.4	1.00	PKS	mensacaricin	Streptomyces bottropensis
BGC0000231.5	0.73	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000234.5	0.64	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000272.3	0.61	PKS	spore pigment	Streptomyces collinus
BGC0001723.5	0.61	PKS	oviedomycin	Streptomyces antibioticus
BGC0002276.2	0.59	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0001197.5	0.58	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0000271.5	0.56	PKS	spore pigment	Streptomyces avermitilis
BGC0000218.5	0.54	PKS	doxorubicin	Streptomyces peucetius
BGC0002000.4	0.54	PKS	setomimycin	Streptomyces aurantiacus JA 4570

Similar known clusters from MIBiG 4.0

Detailed domain annotation

Selected features only

Show module domains

Type II PKS

Type II PKS gene cluster prediction details

Cluster section:: 0 to 36742
Starter unit(s):: acetyl-CoA (Score: 0.0; E-value: 0)
Malonyl elongations:: 8|9 (Score: 683.0; E-value: 2.7e-208)
Product molecular weight(s):: acetyl-CoA_8: 337 Da
acetyl-CoA_9: 379 Da

msnC1: CYC C7-C12 (Score: 316.9; E-value: 2.5e-97)
msnC2: CYC C5-C14 (Score: 485.0; E-value: 1.8e-148)
msnC3: CYC C7-C12 (Score: 498.9; E-value: 1e-152)
msnK1: KS (Score: 775.9; E-value: 2.1e-236)
msnK2: CLF 8|9 (Score: 683.0; E-value: 2.7e-208)
msnK3: ACP (Score: 114.6; E-value: 3.7e-36)
msnO1: KR (Score: 217.4; E-value: 6.2e-67)
msnO10: KR (Score: 199.2; E-value: 2.3e-61)
msnO11: KR C9 (Score: 475.8; E-value: 7.5e-146)