BGC0001177: mensacaricin biosynthetic gene cluster from Streptomyces bottropensis
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 1 - 36,742 nt. (total: 36,742 nt).
This entry is originally from NCBI GenBank KJ437437.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Polyketide
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001177
Short description mensacaricin biosynthetic gene cluster from Streptomyces bottropensis
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide (Other)
Loci NCBI GenBank: KJ437437.1
Compounds
  • mensacaricin
Species Streptomyces bottropensis [taxonomy]
References
Chemical products information
mensacaricin
Copy SMILES
C21H24O9
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AHL46681.1
  • msnO1
 10041 - 10787 (-) ketoreductase
copy AA seq
copy Nt seq
  • AHL46682.1
  • msnO2
 10963 - 12018 (-) luciferase-like monooxygenase
copy AA seq
copy Nt seq
  • AHL46683.1
  • msnO3
 12015 - 12536 (-) flavin reductase
  • Other enzymatic
Activity assay
copy AA seq
copy Nt seq
  • AHL46684.1
  • msnH5
 12564 - 13667 (-) hypothetical protein
copy AA seq
copy Nt seq
  • AHL46685.1
  • msnK2
 13727 - 14932 (-) ketosynthase
copy AA seq
copy Nt seq
  • AHL46686.1
  • msnK1
 15028 - 16293 (-) ketosynthase
copy AA seq
copy Nt seq
  • AHL46687.1
  • msnH6
 16365 - 17210 (-) hypothetical protein
copy AA seq
copy Nt seq
  • AHL46688.1
  • msnO4
 17207 - 18286 (-) luciferase-like monooxygenase
copy AA seq
copy Nt seq
  • AHL46689.1
  • msnO5
 18310 - 18615 (-) monooxygenase
copy AA seq
copy Nt seq
  • AHL46690.1
  • msnC1
 18644 - 19891 (-) putative bifunctional cyclase/dehydratase
copy AA seq
copy Nt seq
  • AHL46691.1
  • msnO6
 19881 - 20198 (-) monooxygenase
copy AA seq
copy Nt seq
  • AHL46692.1
  • msnO7
 20409 - 20723 (+) monooxygenase
copy AA seq
copy Nt seq
  • AHL46693.1
  • msnC2
 20720 - 21643 (+) putative cyclase
copy AA seq
copy Nt seq
  • AHL46694.1
  • msnO8
 21678 - 22682 (+) luciferase-like monooxygenase
  • Activation / processing
Activity assay
Knock-out
copy AA seq
copy Nt seq
  • AHL46695.1
  • msnO9
 22735 - 23706 (+) putative NADPH:quinone oxidoreductase
copy AA seq
copy Nt seq
  • AHL46696.1
  • msnO10
 23762 - 24544 (+) ketoreductase
copy AA seq
copy Nt seq
  • AHL46697.1
  • msnK3
 24585 - 24881 (+) acyl carrier protein
copy AA seq
copy Nt seq
  • AHL46698.1
  • msnO11
 24874 - 25659 (+) ketoreductase
copy AA seq
copy Nt seq
  • AHL46699.1
  • msnC3
 25720 - 26664 (+) putative bifunctional cyclase/dehydratase
copy AA seq
copy Nt seq
  • AHL46700.1
  • msnR1
 27058 - 27909 (+) SARP regulatory protein
copy AA seq
copy Nt seq
  • AHL46701.1
  • msnH7
 27944 - 28855 (+) hypothetical protein
copy AA seq
copy Nt seq
  • AHL46702.1
  • msnH8
 28852 - 29187 (+) hypothetical protein
copy AA seq
copy Nt seq
  • AHL46703.1
  • msnR2
 29338 - 32181 (-) regulatory protein
copy AA seq
copy Nt seq
  • AHL46704.1
  • msnM1
 32650 - 34113 (-) adenosylhomocysteinase
copy AA seq
copy Nt seq
  • AHL46705.1
  • msnM2
 34091 - 34996 (-) N5,N10-methylene etrahydrofolate reductase
copy AA seq
copy Nt seq
  • AHL46706.1
  • msnM3
 34993 - >36741 (-) methionine synthase
copy AA seq
copy Nt seq
Polyketide-specific information
Subclass Other
Starter unit Acetyl-CoA
Ketide length 10
Cyclic? yes
Polyketide-synthases
Genes Properties Modules
msnC3
+
msnC2
+
msnC1
+
msnK3
+
msnK1 		Synthase subclass: Type II
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: LPHAMZXQ3BT6INJWOLKUYGWU, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.