Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001177.1:
Cluster 1Polyketide136742

BGC0001177, mensacaricin biosynthetic gene cluster from Streptomyces bottropensis. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Mensacaricin
PubChem ID: 403671
SMILES string: Copy to clipboard
Molecular formula: C21H24O9
Average molecular mass: 420.414 Da
Molecular activity: Cytotoxic

Class-specific details

Biosynthetic class(es):
Polyketide subclass:
Other (cyclic)
Polyketide synthase subclass:
Type II
Starter unit:
Polyketide synthase / ketosynthase-encoding genes:
Genes involved in folding/cyclization:
AHL46690.1, AHL46693.1, AHL46699.1

Gene cluster description

mensacaricin (BGC0001177). Gene Cluster 1. Biosynthetic class = Polyketide. GenBank KJ437437. Click on genes for more information.


biosynthetic genes
transport-related genes
regulatory genes
other genes

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Heterologous expression
Contact for this cluster:Andreas Bechthold (Albert-Ludwigs-Universitaet Freiburg)

Literature references

1. Yan X et al. (2012) Cloning and heterologous expression of three type II PKS gene clusters from Streptomyces bottropensis. Chembiochem 13(2):224-30. doi: 10.1002/cbic.201100574. Epub 2011 Dec
2. Maier S et al. (2014) Insights into the bioactivity of mensacarcin and epoxide formation by MsnO8. Chembiochem 15(5):749-56. doi: 10.1002/cbic.201300704. Epub 2014 Feb