BGC0001178: UK-68,597 biosynthetic gene cluster from Actinoplanes sp. ATCC 53533
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Location: 1 - 80,908 nt. (total: 80,908 nt).
This entry is originally from NCBI GenBank KF192710.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001178
Short description UK-68,597 biosynthetic gene cluster from Actinoplanes sp. ATCC 53533
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
KF192710.1
via Enzymatic assays
Compounds
  • UK-68,597
Species Actinoplanes sp. ATCC 53533 [taxonomy]
References
Chemical products information
UK-68,597 Evidence:
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C71H63Cl4N7O29S1
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AGS77300.1
 137 - 1102 (+) D-ala-D-ala ligase
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    • AGS77301.1
    		 1135 - 2268 (-) Integral membrane sensor kinase
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      • AGS77302.1
      		 2341 - 2934 (+) DD-carboxypeptidase
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        • AGS77303.1
        		 3124 - 4860 (+) Teg18-like protein
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          • AGS77304.1
          		 4917 - 6011 (+) Dyp-type peroxidase
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            • AGS77305.1
            		 6092 - 6784 (+) Two component response regulator
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              • AGS77306.1
              		 6800 - 7852 (-) D-lactate dehydrogenase
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                • AGS77307.1
                		 8313 - 14567 (+) NRPS modules 1-2
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                  • AGS77308.1
                  		 14564 - 18673 (+) NRPS module 3
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                    • AGS77309.1
                    		 19111 - 31326 (+) NRPS modules 4-6
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                      • AGS77310.1
                      		 31360 - 36972 (+) NRPS module 7
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                        • AGS77311.1
                        		 36974 - 38044 (+) Thymidylyltransferase
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                          • AGS77312.1
                          		 38089 - 38724 (-) Epimerase
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                            • AGS77313.1
                            		 38739 - 39953 (-) Methyltransferase
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                              • AGS77314.1
                              		 40226 - 41449 (+) GtfB glycosyltransferase
                              • Tailoring
                              • Activity assay
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                              • AGS77315.1
                              		 41515 - 42732 (+) GtfC glycosyltransferase
                              • Tailoring
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                              • AGS77316.1
                              		 42860 - 43981 (+) Aminotransferase
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                                • AGS77317.1
                                		 43978 - 45372 (+) NDP hexose dehydratase
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                                  • AGS77318.1
                                  		 45466 - 46620 (+) Gtf glycosyltransferase
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                                    • AGS77319.1
                                    		 46730 - 48715 (+) ABC transporter
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                                      • AGS77320.1
                                      		 48833 - 49042 (+) MbtH-like protein
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                                        • AGS77321.1
                                        		 49155 - 50330 (+) OxyA monooxygenase
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                                          • AGS77322.1
                                          		 50353 - 51507 (+) OxyE monooxygenase
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                                            • AGS77323.1
                                            		 51497 - 52693 (+) OxyB monooxygenase
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                                              • AGS77324.1
                                              		 52735 - 53574 (+) Sulfotransferase
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                                              • AGS77325.1
                                              		 53672 - 55147 (+) Halogenase
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                                                • AGS77326.1
                                                		 55241 - 56473 (+) OxyC monooxygenase
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                                                  • AGS77327.1
                                                  		 56541 - 57875 (+) Halogenase
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                                                    • AGS77328.1
                                                    		 57885 - 59477 (+) beta hydroxylase
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                                                      • AGS77329.1
                                                      		 59794 - 60849 (+) DAHP synthase
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                                                        • AGS77330.1
                                                        		 61487 - 62476 (+) StrR-like transcriptional regulator
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                                                          • AGS77331.1
                                                          		 62552 - 64135 (-) Hydrolase
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                                                            • AGS77332.1
                                                            		 64317 - 65120 (+) Hypothetical protein
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                                                              • AGS77333.1
                                                              		 65141 - 66286 (-) Hmo
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                                                                • AGS77334.1
                                                                		 66978 - 69401 (+) LuxR-like transcriptional regulator
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                                                                  • AGS77335.1
                                                                  		 69657 - 71018 (+) Membrane ion antiporter
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                                                                    • AGS77336.1
                                                                    		 71131 - 72450 (+) HpgT
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                                                                      • AGS77337.1
                                                                      		 72450 - 72812 (+) Chorismate mutase
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                                                                        • AGS77338.1
                                                                        		 72852 - 73913 (+) HmaS
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                                                                          • AGS77339.1
                                                                          		 73916 - 75325 (+) Pdh
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                                                                            • AGS77340.1
                                                                            		 75482 - 76606 (+) DpgA
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                                                                              • AGS77341.1
                                                                              		 76603 - 77268 (+) DpgB
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                                                                                • AGS77342.1
                                                                                		 77265 - 78566 (+) DpgC
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                                                                                  • AGS77343.1
                                                                                  		 78563 - 79363 (+) DpgD
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                                                                                    • AGS77344.1
                                                                                    		 79424 - 80287 (+) Hydrolase
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                                                                                      • AGS77345.1
                                                                                      		 80305 - 80787 (+) MarR-like transcriptional regulator
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                                                                                        Biosynthesis information

                                                                                        Biosynthetic modules

                                                                                        Name
                                                                                        1
                                                                                        Type
                                                                                        nrps-type1
                                                                                        Genes
                                                                                        AGS77307.1
                                                                                        Substrates
                                                                                        4-hydroxyphenylglycine (evidence: Structure-based inference)
                                                                                        Integrated Monomers
                                                                                        Domains
                                                                                        condensation, adenylation, epimerase
                                                                                        Name
                                                                                        2
                                                                                        Type
                                                                                        nrps-type1
                                                                                        Genes
                                                                                        AGS77307.1
                                                                                        Substrates
                                                                                        tyrosine (evidence: Structure-based inference)
                                                                                        Integrated Monomers
                                                                                        Domains
                                                                                        condensation, adenylation, epimerase
                                                                                        Name
                                                                                        3
                                                                                        Type
                                                                                        nrps-type1
                                                                                        Genes
                                                                                        AGS77308.1
                                                                                        Substrates
                                                                                        3,5-dihydroxyphenylglycine (evidence: Structure-based inference)
                                                                                        Integrated Monomers
                                                                                        Domains
                                                                                        condensation, adenylation
                                                                                        Name
                                                                                        5
                                                                                        Type
                                                                                        nrps-type1
                                                                                        Genes
                                                                                        AGS77309.1
                                                                                        Substrates
                                                                                        4-hydroxyphenylglycine (evidence: Structure-based inference [1])
                                                                                        Integrated Monomers
                                                                                        Domains
                                                                                        condensation, adenylation, epimerase
                                                                                        Name
                                                                                        4
                                                                                        Type
                                                                                        nrps-type1
                                                                                        Genes
                                                                                        AGS77309.1
                                                                                        Substrates
                                                                                        4-hydroxyphenylglycine (evidence: Structure-based inference [1])
                                                                                        Integrated Monomers
                                                                                        Domains
                                                                                        condensation, adenylation, epimerase
                                                                                        Name
                                                                                        6
                                                                                        Type
                                                                                        nrps-type1
                                                                                        Genes
                                                                                        AGS77309.1
                                                                                        Substrates
                                                                                        tyrosine (evidence: Structure-based inference [1])
                                                                                        Integrated Monomers
                                                                                        Domains
                                                                                        condensation, adenylation
                                                                                        Name
                                                                                        7
                                                                                        Type
                                                                                        nrps-type1
                                                                                        Genes
                                                                                        AGS77310.1
                                                                                        Substrates
                                                                                        3,5-dihydroxyphenylglycine (evidence: Structure-based inference)
                                                                                        Integrated Monomers
                                                                                        Domains
                                                                                        condensation, adenylation
                                                                                        Annotation changelog

                                                                                        Entry version: 4

                                                                                        Date
                                                                                        Changes
                                                                                        Submitters
                                                                                        Reviewers
                                                                                        2022-10-07
                                                                                        Update chemical activity to schema version 2.11
                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                        Entry version: 3

                                                                                        Date
                                                                                        Changes
                                                                                        Submitters
                                                                                        Reviewers
                                                                                        2022-09-15
                                                                                        Cleaned up synonym list
                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                        2022-09-15
                                                                                        Corrected NRP module activity
                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                        2022-09-15
                                                                                        Updated NRP substrate specificities
                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                        Entry version: 2

                                                                                        Date
                                                                                        Changes
                                                                                        Submitters
                                                                                        Reviewers
                                                                                        2019-10-16
                                                                                        Migrated from v1.4
                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                        Entry version: 1

                                                                                        Date
                                                                                        Changes
                                                                                        Submitters
                                                                                        Reviewers
                                                                                        2015-06-12
                                                                                        Submitted
                                                                                        • (ID: L2Z4MI3G5WXN6AS52Y55RDTF)
                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                        Detailed domain annotation
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