BGC0001178: UK-68,597 biosynthetic gene cluster from Actinoplanes sp. ATCC 53533
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Location: 1 - 80,908 nt. (total: 80,908 nt).
This entry is originally from NCBI GenBank KF192710.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
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NRP
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NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001178
Short description UK-68,597 biosynthetic gene cluster from Actinoplanes sp. ATCC 53533
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP (Glycopeptide)
Loci NCBI GenBank: KF192710.1
Compounds
  • UK-68,597
Species Actinoplanes sp. ATCC 53533 [taxonomy]
References
Chemical products information
UK-68,597
Copy SMILES
C71H63Cl4N7O29S1
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AGS77300.1
 137 - 1102 (+) D-ala-D-ala ligase
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  • AGS77301.1
 1135 - 2268 (-) Integral membrane sensor kinase
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  • AGS77302.1
 2341 - 2934 (+) DD-carboxypeptidase
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  • AGS77303.1
 3124 - 4860 (+) Teg18-like protein
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  • AGS77304.1
 4917 - 6011 (+) Dyp-type peroxidase
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  • AGS77305.1
 6092 - 6784 (+) Two component response regulator
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  • AGS77306.1
 6800 - 7852 (-) D-lactate dehydrogenase
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  • AGS77307.1
 8313 - 14567 (+) NRPS modules 1-2
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  • AGS77308.1
 14564 - 18673 (+) NRPS module 3
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  • AGS77309.1
 19111 - 31326 (+) NRPS modules 4-6
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  • AGS77310.1
 31360 - 36972 (+) NRPS module 7
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  • AGS77311.1
 36974 - 38044 (+) Thymidylyltransferase
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  • AGS77312.1
 38089 - 38724 (-) Epimerase
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  • AGS77313.1
 38739 - 39953 (-) Methyltransferase
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  • AGS77314.1
 40226 - 41449 (+) GtfB glycosyltransferase
  • Tailoring (Glycosylation)
Activity assay
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  • AGS77315.1
 41515 - 42732 (+) GtfC glycosyltransferase
  • Tailoring (Glycosylation)
Sequence-based prediction
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  • AGS77316.1
 42860 - 43981 (+) Aminotransferase
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  • AGS77317.1
 43978 - 45372 (+) NDP hexose dehydratase
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  • AGS77318.1
 45466 - 46620 (+) Gtf glycosyltransferase
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  • AGS77319.1
 46730 - 48715 (+) ABC transporter
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  • AGS77320.1
 48833 - 49042 (+) MbtH-like protein
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  • AGS77321.1
 49155 - 50330 (+) OxyA monooxygenase
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  • AGS77322.1
 50353 - 51507 (+) OxyE monooxygenase
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  • AGS77323.1
 51497 - 52693 (+) OxyB monooxygenase
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  • AGS77324.1
 52735 - 53574 (+) Sulfotransferase
  • Tailoring (Sulfation)
Activity assay
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  • AGS77325.1
 53672 - 55147 (+) Halogenase
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  • AGS77326.1
 55241 - 56473 (+) OxyC monooxygenase
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  • AGS77327.1
 56541 - 57875 (+) Halogenase
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  • AGS77328.1
 57885 - 59477 (+) beta hydroxylase
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  • AGS77329.1
 59794 - 60849 (+) DAHP synthase
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  • AGS77330.1
 61487 - 62476 (+) StrR-like transcriptional regulator
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  • AGS77331.1
 62552 - 64135 (-) Hydrolase
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  • AGS77332.1
 64317 - 65120 (+) Hypothetical protein
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  • AGS77333.1
 65141 - 66286 (-) Hmo
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  • AGS77334.1
 66978 - 69401 (+) LuxR-like transcriptional regulator
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  • AGS77335.1
 69657 - 71018 (+) Membrane ion antiporter
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  • AGS77336.1
 71131 - 72450 (+) HpgT
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  • AGS77337.1
 72450 - 72812 (+) Chorismate mutase
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  • AGS77338.1
 72852 - 73913 (+) HmaS
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  • AGS77339.1
 73916 - 75325 (+) Pdh
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  • AGS77340.1
 75482 - 76606 (+) DpgA
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  • AGS77341.1
 76603 - 77268 (+) DpgB
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  • AGS77342.1
 77265 - 78566 (+) DpgC
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  • AGS77343.1
 78563 - 79363 (+) DpgD
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  • AGS77344.1
 79424 - 80287 (+) Hydrolase
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  • AGS77345.1
 80305 - 80787 (+) MarR-like transcriptional regulator
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NRP-specific information
Subclass Glycopeptide
Cyclic? no
Release type
  • Hydrolysis
Thioesterase genes
  • AGS77310.1 (Type I)
NRP-synthases
Gene Modules
AGS77307.1
Module 1
Specificity: 4-hydroxyphenylglycine
Evidence for specificity:
  • Structure-based inference
Genes encoding specified AA: AGS77336.1, AGS77333.1, AGS77338.1, AGS77339.1
Condensation domain type: Unknown
Module 2
Specificity: tyrosine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: Unknown
AGS77308.1
Module 3
Specificity: 3,5-dihydroxyphenylglycine
Evidence for specificity:
  • Structure-based inference
Genes encoding specified AA: AGS77340.1, AGS77341.1, AGS77342.1, AGS77343.1, AGS77336.1
Condensation domain type: Unknown
AGS77309.1
Module 5
Specificity: 4-hydroxyphenylglycine
Evidence for specificity:
  • Structure-based inference
Genes encoding specified AA: AGS77336.1, AGS77333.1, AGS77338.1, AGS77339.1
Condensation domain type: Unknown
Module 4
Specificity: 4-hydroxyphenylglycine
Evidence for specificity:
  • Structure-based inference
Genes encoding specified AA: AGS77336.1, AGS77333.1, AGS77338.1, AGS77339.1
Condensation domain type: Unknown
Module 6
Specificity: tyrosine
Evidence for specificity:
  • Structure-based inference
Genes encoding specified AA: AGS77328.1
Condensation domain type: Unknown
AGS77310.1
Module 7
Specificity: 3,5-dihydroxyphenylglycine
Evidence for specificity:
  • Structure-based inference
Genes encoding specified AA: AGS77340.1, AGS77341.1, AGS77342.1, AGS77343.1, AGS77336.1
Condensation domain type: Unknown
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: L2Z4MI3G5WXN6AS52Y55RDTF, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Cleaned up synonym list
  • Corrected NRP module activity
  • Updated NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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