Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001178.1:
Cluster 1NRP180908

BGC0001178, UK-68,597 biosynthetic gene cluster from Actinoplanes sp. ATCC. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: UK-68,597
SMILES string: Copy to clipboard
Molecular formula: C71H63Cl4N7O29S
Exact molecular mass: 1648 Da ([M-H]-)
Molecular activity: Antibacterial
Molecular target: D-Ala-D-Ala terminus of peptidoglycan precursors

Class-specific details

Biosynthetic class(es):
NRP
Glycopeptide (linear)
Thioesterase type:
Type I
Release / cyclization type:
Hydrolysis

Nonribosomal peptide synthetases:
AGS77307.1
Module 1
A specificity: 4-Hydroxyphenylglycine
Evidence for specificity: Structure-based inference
AA is epimerized
Amino acid biosynthesis subcluster: ags77336.1,ags77333.1,ags77338.1,ags77339.1
C domain subtype: Unknown
Module 2
A specificity: Tyrosine
Evidence for specificity: Structure-based inference
AA is epimerized
C domain subtype: Unknown
AGS77308.1
Module 3
A specificity: 3,5-Dihydroxy-phenylglycine
Evidence for specificity: Structure-based inference
Amino acid biosynthesis subcluster: ags77340.1,ags77341.1,ags77342.1,ags77343.1,ags77336.1
C domain subtype: Unknown
AGS77309.1
Module 5
A specificity: 4-Hydroxyphenylglycine
Evidence for specificity: Unknown
AA is epimerized
Amino acid biosynthesis subcluster: ags77336.1,ags77333.1,ags77338.1,ags77339.1
C domain subtype: Unknown
Module 4
A specificity: 4-Hydroxyphenylglycine
Evidence for specificity: Structure-based inference
AA is epimerized
Amino acid biosynthesis subcluster: ags77336.1,ags77333.1,ags77338.1,ags77339.1
C domain subtype: Unknown
Module 6
A specificity: Tyrosine
Evidence for specificity: Structure-based inference
Amino acid biosynthesis subcluster: ags77328.1
C domain subtype: Unknown
AGS77310.1
Module 7
A specificity: 3,5-Dihydroxy-phenylglycine
Evidence for specificity: Structure-based inference
Amino acid biosynthesis subcluster: ags77340.1,ags77341.1,ags77342.1,ags77343.1,ags77336.1
C domain subtype: Unknown

Gene cluster description

UK-68,597 (BGC0001178). Gene Cluster 1. Biosynthetic class = NRP. GenBank KF192710. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Enzymatic assays, Sequence-based prediction
MIxS-compliance:Unknown
Contact for this cluster:Gerry Wright (McMaster University)

Literature references

1. Yim G et al. (2014) Harnessing the synthetic capabilities of glycopeptide antibiotic tailoring enzymes: characterization of the UK-68,597 biosynthetic cluster. Chembiochem 15(17):2613-23. doi: 10.1002/cbic.201402179. Epub 2014