Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001179.1:
Cluster 1Polyketide146538

BGC0001179, rishirilide B biosynthetic gene cluster from Streptomyces bottropensis. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Rishirilide B
SMILES string: Copy to clipboard
Molecular formula: C21H24O6
Exact molecular mass: 371.3 Da ([M-H]-)
Molecular activity: Inhibitor
Molecular target: a2-macroglobulin, glutathione-S-transferase

Class-specific details

Biosynthetic class(es):
Polyketide
Polyketide subclass:
Other (cyclic)
Polyketide synthase subclass:
Type II
Starter unit:
Other
Polyketide synthase / ketosynthase-encoding genes:
AHL46708.1,AHL46710.1
Genes involved in folding/cyclization:
AHL46720.1, AHL46724.1, AHL46707.1

Gene cluster description

rishirilide B (BGC0001179). Gene Cluster 1. Biosynthetic class = Polyketide. GenBank KJ437438. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Heterologous expression
MIxS-compliance:Unknown
Contact for this cluster:Andreas Bechthold (Albert-Ludwigs-University of Freiburg, Germany)

Literature references

1. Yan X et al. (2012) Cloning and heterologous expression of three type II PKS gene clusters from Streptomyces bottropensis. Chembiochem 13(2):224-30. doi: 10.1002/cbic.201100574. Epub 2011 Dec
2. Iwaki H et al. (1984) Structures of rishirilides A and B, alpha 2-macroglobulin inhibitors produced by Streptomyces rishiriensis OFR-1056. J Antibiot (Tokyo) 37(9):1091-3.
3. Komagata D et al. (1992) Isolation of glutathione-S-transferase inhibitors. J Antibiot (Tokyo) 45(10):1681-3.