BGC0001182: chaetoglobosins biosynthetic gene cluster from Chaetomium globosum CBS 148.51
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Location: 3,830,915 - 3,864,915 nt. (total: 34,001 nt).
This entry is originally from NCBI GenBank NT_165976.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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Gene details
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General
Compounds
Genes
Polyketide
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001182
Short description chaetoglobosins biosynthetic gene cluster from Chaetomium globosum CBS 148.51
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide (Other)
Loci NCBI GenBank: NT_165976.1
Compounds
  • chaetoglobosins
Species Chaetomium globosum CBS 148.51 [taxonomy]
References
Chemical products information
chaetoglobosins
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C34H40N2O5
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CHGG_01237
  • XP_001220458.1
 3830915 - 3832525 (-) uncharacterized protein
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  • CHGG_01238
  • XP_001220459.1
 3833962 - 3835398 (+) uncharacterized protein
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  • CHGG_01239
  • XP_001220460.1
 3837737 - 3853747 (-) uncharacterized protein
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  • CHGG_01240
  • XP_001220461.1
 3854705 - 3855890 (-) enoyl reducctase
  • Scaffold biosynthesis
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  • CHGG_01241
  • XP_001220462.1
 3856518 - 3857789 (+) uncharacterized protein
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  • CHGG_01242
  • XP_001220463.1
 3858380 - 3862541 (-) uncharacterized protein
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  • CHGG_01243
  • XP_001220464.1
 3863829 - 3864908 (-) cytochrome P450 oxidoreductase
  • Tailoring (Oxidation)
Heterologous expression
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Polyketide-specific information
Subclass Other
Starter unit Acetyl-CoA
Cyclic? no
Polyketide-synthases
Genes Properties Modules
CHGG_01239 Synthase subclass: Iterative type I
Iterative PKS type: Highly reducing, Unknown
Iteration counts: 8
NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
CHGG_01239
Module 1
Specificity: tryptophan
Evidence for specificity:
  • Structure-based inference
Condensation domain type: Unknown
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: ZUAEFEJPIFGA5SNZGJWBG3IU, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Corrected NRP module activity
  • Corrected gene identifiers
  • Changed amino acid substrates to lower case
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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