Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001182.1:
Cluster 1NRP / Polyketide135737

BGC0001182, chaetoglobosins biosynthetic gene cluster from Chaetomium globosum. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: chaetoglobosins
SMILES string: Copy to clipboard
Molecular activity: Cytotoxic

Class-specific details

Biosynthetic class(es):
NRP / Polyketide
Other (linear)
Thioesterase type:
None
Release / cyclization type:
Unknown

Nonribosomal peptide synthetases:
CHGG_01239 (XP_001220460)
Module 1
A specificity: Tryptophan
Evidence for specificity: Structure-based inference
C domain subtype: Unknown
Polyketide subclass:
Other (linear)
Polyketide synthase subclass:
Iterative type I
Starter unit:
Acetyl-CoA
Polyketide synthase / ketosynthase-encoding genes:
XP_001220460
Iterative PKS subtype:
Highly reducing
8
Thioesterase type:
None
Release / cyclization type:
Unknown

Gene cluster description

chaetoglobosins (BGC0001182). Gene Cluster 1. Biosynthetic class = NRP/Polyketide. GenBank NT_165976, positions 3830915-3866651. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies, Heterologous expression
MIxS-compliance:Unknown
Contact for this cluster:Yuta Tsunematsu (University of Shizuoka)

Literature references

1. Schumann J, Hertweck C. (2007) Molecular basis of cytochalasan biosynthesis in fungi: gene cluster analysis and evidence for the involvement of a PKS-NRPS hybrid synthase by RNA silencing. J Am Chem Soc 129(31):9564-5. doi: 10.1021/ja072884t. Epub 2007 Jul
2. Tee W et al. (1987) Atypical campylobacters associated with gastroenteritis. J Clin Microbiol 25(7):1248-52.