Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001187.1:
Cluster 1NRP / Polyketide112562

BGC0001187, xenolozoyenone biosynthetic gene cluster from Glarea lozoyensis. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: xenolozoyenone
SMILES string: Copy to clipboard
Molecular formula: C17H23NO4
Exact molecular mass: 306.1708 Da ([M+H]+)
Molecular activity: Unknown

Class-specific details

Biosynthetic class(es):
NRP / Polyketide
Nonribosomal peptide subclass:
Other lipopeptide (cyclic)
(4E,6E,8E)-3-oxopentadeca-4,6,8-trienoic acid
Thioesterase type:
Unknown
Release / cyclization type:
Other

Nonribosomal peptide synthetases:
glnrps7 (AKL78825.1)
Module 2
A specificity: Glycine
Evidence for specificity: Structure-based inference
C domain subtype: Other
Polyketide subclass:
Other (cyclic)
Polyketide synthase subclass:
Iterative type I
Starter unit:
Propionyl-CoA
Polyketide synthase / ketosynthase-encoding genes:
AKL78824.1
Iterative PKS subtype:
Highly reducing
Number of iterations:
6
Other
Thioesterase type:
None
Release / cyclization type:
Other

Modular polyketide synthases:
glpks3 (AKL78824.1)
Module 1
AT specificity: Propionyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: Unknown
Scaffold-modifying domain: None
Module is iterated
Evidence for iteration: Unknown

Gene cluster description

xenolozoyenone (BGC0001187). Gene Cluster 1. Biosynthetic class = NRP/Polyketide. GenBank KM603664. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

General MIBiG information on this cluster

Complete gene cluster sequence?incomplete
Evidence for cluster-compound connection:Heterologous expression, Gene expression correlated with compound production
MIxS-compliance:Unknown
Contact for this cluster:Qun Yue (University of Texas Health Science Center at Houston)

Literature references

1. Yue Q et al. (2015) Functional Operons in Secondary Metabolic Gene Clusters in Glarea lozoyensis (Fungi, Ascomycota, Leotiomycetes). MBio 6(3):e00703. doi: 10.1128/mBio.00703-15.