LOCUS       BGC0001188              8471 bp    DNA     linear   CON 20-MAR-2022
DEFINITION  Streptomyces sp. CT34 Scaffold1, whole genome shotgun sequence.
ACCESSION   BGC0001188
VERSION     BGC0001188
KEYWORDS    .
SOURCE      Streptomyces sp. CT34
  ORGANISM  Streptomyces sp. CT34
            Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
            Streptomyces.
COMMENT     REFSEQ INFORMATION: The reference sequence is identical to
            KN708638.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            ##antiSMASH-Data-START##
            Version      :: 6.2.0-924c3663(changed)
            Run date     :: 2022-11-07 23:45:45
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 8471
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..192
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="RZ84_RS20230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_043265479.1"
                     /transl_table=11
                     /translation="MNSPVPTQISSYANDHLAKVTPGKVDNGQAVPALSGAKAQISAIT
                     PTFTDATVLIGIQQAVGH"
     protocluster    1..8471
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[6607:7518]"
                     /cutoff="20000"
                     /detection_rule="(cypemycin or cypI)"
                     /neighbourhood="10000"
                     /product="linaridin"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      6608..7518
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cypemycin or cypI)"
                     /neighbourhood="10000"
                     /product="linaridin"
                     /protocluster_number="1"
     cand_cluster    1..8471
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(cypemycin or cypI)"
                     /kind="single"
                     /product="linaridin"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..8471
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0001188"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..8471
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="linaridin"
                     /region_number="1"
                     /rules="(cypemycin or cypI)"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            1..192
                     /locus_tag="RZ84_RS20230"
     gene            574..2424
                     /locus_tag="RZ84_RS20235"
     CDS             574..2424
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 321.7; E-value:
                     1.6e-97)"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003991974.1"
                     /locus_tag="RZ84_RS20235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein/permease"
                     /protein_id="WP_052230046.1"
                     /transl_table=11
                     /translation="MLLITGVLLGLLGVGASLTQPWAIGKLIEAAGKGESLAFPIVRLV
                     GLFCLGAVFSALQAYVIGRAGENIVYDVRQVLTGRLLRADLTEFGKRPQGDILTRTVTD
                     TSLVKIALSQSLAQLIVSGATVIGGVVLMFLIDVRLMLITMGCLGVASLLSLSIARKLR
                     RVAVQNRDDTGEFGTAVQRVLAALPTVKASRAETRETARIGRLAERARRSGIRVNAYNA
                     LFMPSMNVGTQGALAVVVGAGMAWVARGEMNMADLTTFIMYLFQLVSPLVTFFMGVGQF
                     IQGRAAIQRVDELAQMPQEGNGAQAARSSVPIGPLPQHLPAVEFHDVRFGYRRGEEGER
                     TQVLHGISLTVPARGLTAVVGPSGAGKTSMFQLIERFYALDGGVILLGGQNIGTLPLDT
                     VRGLVGYVQQDSATMRGTVRENLTYAHPHASEDDIWEAVEMAGLTSVVANLPKGLDTEL
                     GDQGSGLSGGQRQRLCIARTLLQKPAVMLLDEATSNLDSDSERDFRDVLRRVSQQCAVI
                     AIAHRISTVVDAEKIVVLEGGRVRATGVHRELMEHDELYRRLAGSQLHAGAAPVATATH
                     WVSGEPGAGPLASALGWHQWGSGLNEQTVRLRPIRIEEQW"
     gene            2421..3905
                     /locus_tag="RZ84_RS20240"
     CDS             2421..3905
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222:dehydrogenase (Score: 111.8; E-value: 7.3e-34)"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014135440.1"
                     /locus_tag="RZ84_RS20240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_043270372.1"
                     /transl_table=11
                     /translation="MNSADVAIVGTGPNGLAAGVVLARAGLRVELYEAADTIGGGLRTE
                     PLFDNGVVHDICSAVHPMAAASPFFREFDLEARGVELLHPEISYAHPLDGGRAALAYRS
                     LADTCAHLGPDGPRWRRLMGPLLERSEAVVDLILSGQRSLPRDPAAALLLAGRVAVHGT
                     GLGAARFQGEEAAALLTGVAAHAVGKLPSFAAGAVAMLLGHLAHGTGWPLPRGGSARIA
                     EAMAQDITAHGGVLHTGHPVTDLAELRRARAVLLDTSPKGFLALAGDRLPRSYARGLTR
                     FRYGPGAAKVDFLVSEPIPWADPAVGRAGTVHLGGTHAEMVRQETRNARRVRTREPFVL
                     LVDPAVTDPGRALPGKRPVWAYAHVPNGDPTDPYELVRARIERYAPGFGDTVIAHRSVP
                     AAAYETYNPNYVGGDIGSGAMTLYQSIARPVPRIDPYRTPLPGVFLCSSATPPGPSVHG
                     MSGYLAAVSALRHCFGKCDVPNVGTQSASFASGDLA"
     gene            4374..5132
                     /locus_tag="RZ84_RS20245"
     CDS             4374..5132
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1248:methyltransferase (Score: 88.5; E-value:
                     7.8e-27)"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003991976.1"
                     /locus_tag="RZ84_RS20245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_107068144.1"
                     /transl_table=11
                     /translation="MTNGVEDIGYGRQFEGWYDRLIPDDRITDEAVKGLLALHPAPDAG
                     TIELGVGTGRIAIPLSESVGHVTGVDSSPEMLDAMRVKLKDRGDVTPVHGDIRTYTSDS
                     RYGLVYCVCATLSLLHTREDQQRAVRCAADLLAPGGRLVIETHNKPPILELHEGRRRTT
                     YFVPYPEPGTGVQTHSTLLDGDLWHCSHILYQADGTTRVGNELTRLTTPEDIDDYARAA
                     GLEPEASLSRWDGTPYNEQSPMFACCYVKP"
     gene            5229..5519
                     /locus_tag="RZ84_RS36830"
     CDS             5229..5519
                     /GO_process="GO:0006313 - transposition, DNA-mediated
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013677.2"
                     /locus_tag="RZ84_RS36830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="transposase"
                     /protein_id="WP_241777777.1"
                     /transl_table=11
                     /translation="MSGQLTAAEAAREAGVSEQSVSNWRRQFIEGARNGLAGESGRDSE
                     EASRIAELTKENAMLKATIGELYMELRKYGRSTPGRVPSPRGKTHPVRRVN"
     CDS             5754..6092
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="RZ84_RS20250"
                     /product="hypothetical protein"
                     /sec_met_domain="Abhydrolase_6 (E-value: 2e-11, bitscore:
                     34.5, seeds: 455, tool: rule-based-clusters)"
                     /sec_met_domain="PF00561 (E-value: 2.3e-12, bitscore: 36.7,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="IPPNARRMVLLDNGLGTTHEYWDWVCEALPADMGYVRFNRPGYGL
                     STPSKRYGLERHFALLQELRETYVADLPLVLAGHSLGGYFVAAYASLHPGAKEGVTGVV
                     MIDATDVAH"
     gene            5775..6611
                     /locus_tag="RZ84_RS35120"
     CDS             5775..6611
                     /NRPS_PKS="Domain: Thioesterase (54-246). E-value: 5.1e-09.
                     Score: 28.7. Matches aSDomain:
                     nrpspksdomains_RZ84_RS35120_Thioesterase.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003991978.1"
                     /locus_tag="RZ84_RS35120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_241777778.1"
                     /sec_met_domain="Abhydrolase_6 (E-value: 3.2e-16, bitscore:
                     50.2, seeds: 455, tool: rule-based-clusters)"
                     /sec_met_domain="PF00561 (E-value: 3.6e-12, bitscore: 36.1,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVLLDNGLGTTHEYWDWVCEALPADMGYVRFNRPGYGLSTPSKRY
                     GLERHFALLQELRETYVADLPLVLAGHSLGGYFVAAYASLHPGAKEGVTGVVMIDATDV
                     AHLRSSRRADIDRWSRQSMLMEQVFAVAGLSALRPALNQHKTYRPEINRSYTAFLAQRR
                     TWALAYRDYRDAMTYPELASVDSPLTVITAENNKGDNAAHQKVQAKLATLSKRSRQRCI
                     DGSDHESLLSIQPHAAQVAEIIADEPPTGRADAERRKSAGARPAVKSAADREKELM"
     aSDomain        5937..6512
                     /aSDomain="Thioesterase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_RZ84_RS35120_Thioesterase.1"
                     /evalue="5.10E-09"
                     /label="RZ84_RS35120_Thioesterase.1"
                     /locus_tag="RZ84_RS35120"
                     /protein_end="246"
                     /protein_start="54"
                     /score="28.7"
                     /tool="antismash"
                     /translation="QELRETYVADLPLVLAGHSLGGYFVAAYASLHPGAKEGVTGVVMI
                     DATDVAHLRSSRRADIDRWSRQSMLMEQVFAVAGLSALRPALNQHKTYRPEINRSYTAF
                     LAQRRTWALAYRDYRDAMTYPELASVDSPLTVITAENNKGDNAAHQKVQAKLATLSKRS
                     RQRCIDGSDHESLLSIQPHAAQVAEIIAD"
     CDS_motif       5970..6005
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_RZ84_RS35120_0001"
                     /evalue="1.00E-03"
                     /label="NRPS-te1"
                     /locus_tag="RZ84_RS35120"
                     /protein_end="77"
                     /protein_start="65"
                     /score="11.7"
                     /tool="antismash"
                     /translation="PLVLAGHSLGGY"
     CDS             6608..6829
                     /locus_tag="RZ84_RS20255"
                     /product="hypothetical protein"
                     /transl_table=1
                     /translation="VTVRVNTERLKTAAVTTSLAAWLVATAVAQMPEQRFDNLLKRGKL
                     RIPTPNWRFFGPNPGVKDNHLLYRDVTDG"
     gene            6608..7195
                     /locus_tag="RZ84_RS35125"
     CDS             6608..7195
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     linaridin: cypI"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006604050.1"
                     /locus_tag="RZ84_RS35125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_052230048.1"
                     /sec_met_domain="cypI (E-value: 1.9e-31, bitscore: 98.9,
                     seeds: 22, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVRVNTERLKTAAVTTSLAAWLVATAVAQMPEQRFDNLLKRGKL
                     RIPTPNWRFFGPNPGVKDNHLLYRDVTDGKPGEWQEIPITRDRAWYALAWNARNRSPKA
                     LFDAVQDVYVRSAAYGTAMEPVVQSSGYQLLSGYIRHHLPHAEGASHSQFLVMYSYLAA
                     PEARQIEPIFVSREFPLEDEGVVQPEPYPVAA"
     CDS             6755..6943
                     /gene_functions="biosynthetic (rule-based-clusters)
                     linaridin: cypI"
                     /gene_kind="biosynthetic"
                     /locus_tag="RZ84_RS20260"
                     /product="hypothetical protein"
                     /sec_met_domain="cypI (E-value: 1.5e-19, bitscore: 60.6,
                     seeds: 22, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="PNWRFFGPNPGVKDNHLLYRDVTDGKPGEWQEIPITRDRAWYALA
                     WNARNRSPKALFDAVQDV"
     gene            7321..7518
                     /locus_tag="RZ84_RS20265"
     CDS             7321..7518
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     linaridin: cypemycin"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF033402.1"
                     /locus_tag="RZ84_RS20265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="linaridin family RiPP"
                     /protein_id="WP_043265481.1"
                     /sec_met_domain="cypemycin (E-value: 1.9e-15, bitscore:
                     46.7, seeds: 4, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVLAEFANTELVDVEPGRLGSEATPTMITPLATLATPEATPVGF
                     AATSATAAAVNMITHDVTRH"
     gene            7617..8471
                     /locus_tag="RZ84_RS20270"
     CDS             7617..8471
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006604049.1"
                     /locus_tag="RZ84_RS20270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_043265482.1"
                     /transl_table=11
                     /translation="MFLKAPPEVTARRVASLGTLVSALEMLSQHRKLADGELLSAQLES
                     TRPEFAKRFPRLTRALSSKKAGVALYGIQAGASAATMIWAHKRGVRAAGSAVLAVTGAA
                     SRLRTPFGGDGADQLQQVINVVLASTGTFKDGDKGRDVAMRALALETTISYVASGVVKL
                     VSPVWLSGEAFSGVIRTHNYGDPNIYKLVHKYPMLGKLITWTTVAAEVGFPLVFVLPKP
                     AAKAYLGSMTLFHLGIGQFMGLNRFVLAFAATHPALLYVFDQSGRRPAVAGNAVAALAP
                     AAA"
ORIGIN
        1 atgaactctc cggtaccgac gcagatcagc tcctacgcga acgaccacct ggcgaaggtc
       61 actcccggga aggtcgacaa cgggcaggcc gtgccggcgc tgagcggcgc caaggcccag
      121 atctccgcca tcaccccgac gttcaccgat gcgacggtgc tgatcggaat acagcaggcg
      181 gtcggtcact aaccgccggc ccctgcgctc ctcctggttg ccggccggga ggagcgcgcc
      241 gtgctgcggt ccgtcgaagc gttcccccgg tatatgcgcc aagtaaagaa cagatgagtt
      301 aacttacccg gcctcatata cctgccgctg atccgcgggg tgatgtgccg gcggctcaac
      361 taactcataa ctttacgccg ggcggcatgt tagcttcgaa caccttgacg acgagtccct
      421 atgagacagg gctgtgttcc tggtcgcgca cgtgccgtga ccgtcgtcaa tacgggggga
      481 gtactcatgg cgagtcatgc cggtcacgcg agcctgagta gcaataccgg acgtggcgca
      541 ggatcggtcg cgggtgtcgc cggacagcac accatgctgc tgatcacggg cgtgctgctg
      601 ggcctgctgg gagtgggcgc ctcgctcacc cagccgtggg ccatcggcaa actgatcgag
      661 gcggcgggca agggcgaatc gctggccttc cccatcgtcc ggctcgtcgg cctcttctgc
      721 ctgggcgcgg tcttctccgc gctccaggca tacgtcatcg ggcgggccgg ggagaacatc
      781 gtctacgacg tccgccaggt cctgaccggg cggctgctcc gcgccgacct caccgaattc
      841 ggcaagcggc cccagggcga catcctcacc cgcacggtca ccgacacctc gctggtgaag
      901 atcgccctct cgcagagcct cgcccagctg atcgtcagcg gcgccaccgt catcggcggt
      961 gtcgtgctga tgttcctcat cgacgtgcgg ctgatgctca tcaccatggg ctgcctcggg
     1021 gtcgccagcc tcctctcgct gtccatcgcc cgcaagttgc gcagggttgc cgtgcagaac
     1081 cgggacgaca ccggcgagtt cggcaccgcc gtacagcgcg tgctcgccgc gctgcccacg
     1141 gtcaaggcat cccgggccga gacgcgggag accgcccgta tcggcaggct ggccgagcgg
     1201 gcacggcgtt cgggtatccg cgtcaacgcc tacaacgccc tgttcatgcc gtccatgaac
     1261 gtcggtacgc agggcgcgct ggccgtcgtc gtgggcgccg gaatggcgtg ggtggcccgc
     1321 ggcgagatga acatggccga cctgaccacg ttcatcatgt acctcttcca gctggtgtcg
     1381 ccgctggtga cgttcttcat gggggtgggc cagttcatcc agggccgggc cgcgatccag
     1441 cgggtcgacg aactcgccca gatgccccag gaaggcaacg gggcgcaggc cgcccggagt
     1501 tccgtgccca tcgggccgct gccccagcac ctgccggcgg tcgagttcca cgacgtgcgg
     1561 ttcgggtacc ggcggggcga ggagggggag cggacgcagg tcctgcacgg catctcgctc
     1621 accgtgccgg cgcgcgggct gacggcggtg gtcgggccct cgggcgcggg caagaccagc
     1681 atgttccagc tgatcgagcg cttctacgcg ctggacggcg gtgtcatcct gctcggcggg
     1741 cagaacatcg ggacgctgcc gctcgacacc gtccgcgggc tggtcggcta cgtccagcag
     1801 gacagcgcga ccatgcgggg cacggtccgg gagaacctga cctacgcgca tccgcacgcc
     1861 agtgaggacg acatctggga ggcggtggag atggccggcc tcacctcggt cgtcgccaac
     1921 ctcccgaagg ggctcgacac cgaactcggc gaccagggca gcgggttgtc cggcgggcag
     1981 cgccagcgcc tgtgcatcgc ccgcacgctg ctccagaagc ccgcggtgat gctgctggac
     2041 gaggccacct ccaacctgga ctccgactcg gagcgggact tccgcgacgt gctgcgccgg
     2101 gtctcccagc agtgcgcggt catcgccatc gcccaccgca tctccacggt ggtcgacgcc
     2161 gagaagatcg tggtgctgga aggcggccgg gtccgcgcca ccggtgtgca ccgggagctg
     2221 atggagcacg acgagctgta ccggcggctg gcgggctccc aactgcacgc cggggcggct
     2281 ccggtcgcca cggcgaccca ctgggtgagc ggggagccgg gggcgggtcc gctcgcctcc
     2341 gcgctcggct ggcaccagtg gggcagcggc ctcaacgagc agacggtgcg gcttcggccc
     2401 atcaggatcg aggagcagtg gtgaacagcg cggacgtggc catcgtcggc accggaccca
     2461 acggcctggc ggccggcgtg gtgctggccc gagccggcct gagagtggag ctctacgaag
     2521 cggccgacac catcggcgga gggctgcgca ccgagccgct cttcgacaac ggtgtcgtgc
     2581 acgacatctg ctccgccgtc catcccatgg ccgccgcctc cccgttcttc cgggagttcg
     2641 acctggaggc ccgcggggtc gagctgctgc accccgagat cagctacgcc catccgctgg
     2701 acgggggccg cgccgccctg gcgtaccgct cgctggctga cacctgcgcg cacctgggtc
     2761 ccgacggtcc gcgctggcgg cggctgatgg gcccgctgct ggagcgcagc gaggccgtcg
     2821 tcgacctgat cctctccggg cagcgcagcc tgccgcggga cccggccgcc gccctgctgc
     2881 tggccggccg ggtggcggtc cacggcaccg ggctcggcgc ggcacgcttc cagggcgagg
     2941 aggcggcggc cctgctcacc ggcgtcgccg cgcacgcggt cggcaaactg cccagtttcg
     3001 cggccggcgc ggtggccatg ctgctcggcc acctggcgca cggcacgggg tggccgctgc
     3061 cgcgcggcgg cagcgcccgt atcgcggagg cgatggccca ggacatcacg gcgcacggcg
     3121 gcgtcctcca caccgggcac cccgtgacgg acctggccga actccgccgc gcgcgagcgg
     3181 tgttgctcga caccagcccc aagggcttcc tggccctcgc gggcgaccgg ctgccccgct
     3241 cctacgcgcg cggcctcacc cgcttccgct acggtccggg cgccgccaag gtcgacttcc
     3301 tggtctccga gccgatcccc tgggccgatc ccgcggtggg ccgcgccggc acggtccatc
     3361 tgggcggcac tcacgccgag atggtccgcc aggagacgcg gaacgcacgc cgcgtgcgga
     3421 cccgggagcc gttcgtcctc ctcgtggacc ccgcggtgac cgatcccggt cgcgcgctgc
     3481 ccgggaagcg ccccgtgtgg gcgtacgcgc atgtcccgaa cggcgatccc accgacccct
     3541 acgagctggt gcgcgcccgc atcgagcgct acgccccggg gttcggggac acggtcatcg
     3601 cccaccgctc cgtgcccgcc gccgcgtacg agacctacaa ccccaactac gtgggcggag
     3661 acatcggttc gggcgcgatg accctctacc agagcatcgc gcgcccggtg ccccgcatcg
     3721 atccctaccg cacaccgctg cccggcgtct tcctgtgctc ctcggccacc ccgccggggc
     3781 ccagtgtgca cggcatgtcc ggctatctgg ccgctgtttc cgcactgcgg cattgtttcg
     3841 ggaaatgtga cgtacccaac gtgggtacgc agtcggcgtc attcgcgagc ggcgacctcg
     3901 cctaaagcgg gccacacctt tccgttccgg cgtcaacgca tgcccgactc tccaggtgtt
     3961 cggggtggtg cgcggcgggg tcgggtgagg cgcgatgaaa ctacgatgaa accgtgcgga
     4021 actccgagtg gtgcccggga cgttgtcgaa gagggcctgc ggtgctccaa tcagggcttt
     4081 cgccggaccg gctatcccac ctgccgggag ctttgcttcc tcgtagcact gcacatattc
     4141 actggagtcc atctcggtgt atatgatgga ctcacacgac ataacctgaa gtccccacac
     4201 ttcgttgagg cgttacctgg atcgacagga actgctggtc tgaccaacca cgcggaactg
     4261 ctgcggatct tccgtgcagt tgtgttggcg tacaacgtcc ttcctcgctc cggctcttcg
     4321 gcttcgcgac ggtcccatcg ggatcgactg tggggacaaa gagagggagt tcggtgacta
     4381 acggggtaga ggacatcggc tatgggcgac agttcgaggg ctggtacgac cggctgatac
     4441 cggacgacag gattaccgac gaggcggtaa aagggctgct ggccctccat cccgctcccg
     4501 atgcggggac cattgagctc ggtgtcggca cgggacggat cgccatcccg ctttccgaga
     4561 gcgtcggcca tgtgaccggt gtggattcct caccggagat gctggacgcg atgcgcgtca
     4621 agctgaagga ccgcggcgat gtcacccccg tccacgggga catccgcacc tacacctcgg
     4681 attcccggta cgggctggtg tattgcgtct gcgcgaccct gtcgctgctg cacacccgcg
     4741 aggaccagca gcgggccgtc cggtgtgcgg ccgacctcct cgcccccggc ggccggctgg
     4801 tgatcgagac gcacaacaag ccgccgatcc tggaacttca cgaaggacgc aggcgcacca
     4861 cgtacttcgt cccctacccg gagcccggca ccggcgtgca gacccattcc acgctgctcg
     4921 acggcgacct gtggcactgc tcgcacatcc tgtaccaggc cgacggcacc acccgggtcg
     4981 ggaacgaact cacccggctg accactccgg aagacatcga cgactacgcc cgcgcggccg
     5041 ggctggagcc cgaggccagt ctttcgcggt gggacggcac cccctataac gaacagtcac
     5101 ccatgttcgc ctgctgctac gtcaagccct gagcgcgcac accggaacgc ggatcacaga
     5161 agggggtcgc agtgggacga ccgccgatat tgccggcaga caagaaactc ggtctcctgg
     5221 tgagagtgat gagtggccaa ctgaccgcgg cggaagccgc gcgggaagcc ggagtctccg
     5281 agcaatccgt atcgaactgg cgtcgacaat ttattgaggg agctcgtaac ggcctggccg
     5341 gcgagagcgg aagggactcc gaagaggcgt cccggattgc cgagctgacc aaagaaaacg
     5401 ccatgctgaa ggccacaata ggcgagctgt atatggaact ccggaagtat gggcggagta
     5461 cgcccggccg agttccgtcc cctcgcggga agactcatcc ggtccggagg gtcaactaac
     5521 tcattaattt acccgggcat tcggtgttag tgtccggggt aacagccact tgaaatcacg
     5581 ggggaggaat tgtggcgtct ttggagcgcc agttcgccgt gggcatcgct gggttggccg
     5641 gcgcaagcgt tctgaccggt gcagcaatgc gattcacggg gaagcgtgaa cgtgcgcgtc
     5701 gctacctgac gcacgagagg ccggacggca gcctcgtaga ggtagacgtc aatattcctc
     5761 cgaatgcccg gcgcatggtc ctgctcgaca acggactggg cacgacccac gaatactggg
     5821 actgggtctg cgaagcactt cccgcggaca tgggatacgt gcggttcaac cggcccggct
     5881 acgggctcag cacaccctcg aagcgctacg gcctggagcg gcatttcgcg ctgctgcagg
     5941 aactgcgcga aacgtacgtc gccgacctgc cgctggtgct ggccgggcac tccctcggtg
     6001 ggtacttcgt cgccgcctac gcgtcgctcc accccggggc gaaggaaggg gtgaccgggg
     6061 tggtcatgat cgacgcgacg gacgtggctc atctgcgctc cagccgccgc gcggacatcg
     6121 accggtggtc ccggcagtcg atgctcatgg agcaggtgtt cgccgtggcg ggcctttcgg
     6181 cgctgcggcc cgccctgaac cagcacaaga cctaccgccc ggaaatcaac cggagttaca
     6241 cggcattcct ggcgcagcgg cgtacctggg ccctggccta ccgcgactac cgggacgcga
     6301 tgacgtatcc ggaactggcc tcggtcgaca gtccgttgac cgtgatcacc gcggagaaca
     6361 acaaggggga caacgccgcg caccagaagg tccaggcaaa gctggccacc ctctcgaagc
     6421 ggtctcggca gcgctgcatc gacggttccg accacgagtc gctgctctcc atccagccgc
     6481 acgccgcaca ggtggcggaa atcatcgccg acgaaccgcc gaccgggcgg gccgacgcgg
     6541 aacggcggaa gtccgccgga gcccgcccgg ccgtcaagag tgccgcggat cgcgagaagg
     6601 agctgatgtg accgtgcggg tgaacacgga gcgcctgaaa acggccgccg tcacgacgtc
     6661 cctcgccgcc tggctcgtcg cgacggcggt ggcccagatg cccgagcagc gcttcgacaa
     6721 tctcctcaag cgcggaaagc tgcggatacc gaccccgaac tggcgtttct tcgggccgaa
     6781 tccgggagtc aaggacaacc atctgctcta cagggatgtc acggacggca agcccggtga
     6841 gtggcaggaa atcccgatca cccgcgaccg ggcctggtac gcactggcct ggaacgcccg
     6901 caaccggtcc cccaaggccc tgttcgacgc ggtccaggac gtctatgtcc gttcggcggc
     6961 ctacggaacg gcgatggagc ccgtggtgca gtcgtccggc taccagctgc tttccggtta
     7021 catccggcac catctgccgc acgccgaagg cgcctcgcac agtcagttcc tggtcatgta
     7081 ctcgtacctt gccgccccgg aggcccggca gatcgagccc atcttcgtct ccagggaatt
     7141 cccgctggaa gacgaaggag ttgtgcagcc ggagccctat cccgtagccg cctagcgggc
     7201 tttgtgaccc tctcggccgg aagccgcgaa ctcactcgga atgactccag gccgcgtgag
     7261 tccgtgccct cccgccgaat ggctggagag tttgctcaaa cgacagaaag aggacagcaa
     7321 atgtctgtgc tggctgagtt cgccaacacc gagctggtcg acgtcgagcc gggccgtctc
     7381 ggctccgagg cgaccccgac catgatcacc ccgctggcca ccctggccac cccggaggcc
     7441 accccggtcg gcttcgcggc cacctcggcg accgccgctg cggtcaacat gatcacgcat
     7501 gacgtcactc gccactgatc gatgagggcg ggggcacggt acgtgtatcg ggcgtaccgt
     7561 gcccccgcct tctgataccc accgaaacca tatccactca cagggggcac tcatccatgt
     7621 ttctcaaagc tccgcccgag gtcacggcac gccgagtggc ctccctgggg acgctggtct
     7681 ccgctctgga aatgctgagc cagcaccgta agctcgccga cggcgaattg ctgagtgccc
     7741 aactggagag cacacgtccc gaattcgcca agcggtttcc ccgactgacc cgtgccctca
     7801 gctccaagaa agcgggggtc gccctctacg gaattcaggc gggagcctcc gccgccacga
     7861 tgatctgggc gcacaagcgc ggagtacgcg cggcgggcag tgccgtgctg gcggtgacgg
     7921 gcgcggcatc acgcctgcgc acccccttcg gtggagacgg cgccgaccag ctccagcagg
     7981 tcatcaacgt cgtcctcgcc tcgaccggca ccttcaagga cggcgacaag ggccgcgacg
     8041 tggccatgcg cgcgctggcc ctggagacga ccatctccta cgtcgcatcc ggtgtcgtca
     8101 agctcgtctc cccggtgtgg ctcagcggag aggcgttcag cggcgtcatc cgcacgcaca
     8161 actacgggga cccgaacatc tacaagctcg tccacaagta cccgatgctg ggcaagctca
     8221 tcacctggac gacggtcgcc gcggaggtcg gcttcccgct ggtcttcgtc ctgccgaagc
     8281 cggcggccaa ggcgtacctc ggctcgatga cgctgttcca cctgggaatc ggtcagttca
     8341 tggggctcaa ccgcttcgtg ctggccttcg ccgccacgca cccggcgctc ctctatgtct
     8401 tcgaccagag cggcaggcgc ccggcggtgg ccggcaacgc agtggcagcc ctcgcgcccg
     8461 ccgccgcgta g
//
